FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206592364> ?p ?o ?g. }

• W4206592364 endingPage "2924" @default.
• W4206592364 startingPage "2915" @default.
• W4206592364 abstract "To investigate the role of microRNA-155-5p on apoptosis and inflammatory response in human renal glomerular endothelial cells (HRGEC) cultured with high glucose.The primary HRGEC were mainly studied, light microscopy was used to detect changes in cell morphology. Quantitative Real Time-Polymerase Chain Reaction, Western Blot, immunofluorescence were aimed to observe the mRNA and protein expression levels of target gene ETS-1, downstream factors VCAM-1, MCP-1 and cleaved caspase-3 in each group after high glucose treatment as well as transfection with miR-155 mimics or inhibitor.The expression of inflammatory factors and apoptosis of HRGEC cells increased under high glucose treatment. Compared with normal-glucose treatment, the expression of microRNA-155 markedly increased in HRGECs treated with high-glucose, as well as the mRNA and protein levels of ETS-1, VCAM-1, MCP-1 and cleaved caspase-3. Overexpression of microRNA-155 remarkably downregulated mRNA and protein levels of ETS-1, VCAM-1, MCP-1 and cleaved caspase-3, whereas miRNA-155 knockdown upregulated their levels. In addition, HRGEC cells were transfected with miR-155 mimics and ETS-1 siRNA with high glucose stimulation. The expression of ETS-1 was positively correlated with the expression of downstream factors VCAM-1 and MCP-1. These results suggest that ETS-1 can mediate endothelial cell inflammation by regulating VCAM-1 and MCP-1.MiR-155 can negatively regulate the expression of target gene ETS-1 and its downstream factors VCAM-1, MCP-1 and cleaved caspase-3, thus mediating the inflammatory response and apoptosis of HRGEC." @default.
• W4206592364 created "2022-01-25" @default.
• W4206592364 creator A5002497837 @default.
• W4206592364 creator A5006602012 @default.
• W4206592364 creator A5037378495 @default.
• W4206592364 creator A5047157625 @default.
• W4206592364 creator A5047319422 @default.
• W4206592364 creator A5063146201 @default.
• W4206592364 creator A5079226794 @default.
• W4206592364 creator A5079355863 @default.
• W4206592364 date "2022-01-21" @default.
• W4206592364 modified "2023-10-14" @default.
• W4206592364 title "The role of microRNA-155 in glomerular endothelial cell injury induced by high glucose" @default.
• W4206592364 cites W1976742584 @default.
• W4206592364 cites W1986774614 @default.
• W4206592364 cites W1994778563 @default.
• W4206592364 cites W1995122286 @default.
• W4206592364 cites W2008834586 @default.
• W4206592364 cites W2021645853 @default.
• W4206592364 cites W2025991566 @default.
• W4206592364 cites W2032413488 @default.
• W4206592364 cites W2046394334 @default.
• W4206592364 cites W2049773911 @default.
• W4206592364 cites W2057683168 @default.
• W4206592364 cites W2060505706 @default.
• W4206592364 cites W2065067995 @default.
• W4206592364 cites W2073552064 @default.
• W4206592364 cites W2089025746 @default.
• W4206592364 cites W2099017523 @default.
• W4206592364 cites W2101508556 @default.
• W4206592364 cites W2110001721 @default.
• W4206592364 cites W2110408951 @default.
• W4206592364 cites W2130266732 @default.
• W4206592364 cites W2140298033 @default.
• W4206592364 cites W2142930342 @default.
• W4206592364 cites W2143914224 @default.
• W4206592364 cites W2153816764 @default.
• W4206592364 cites W2167440496 @default.
• W4206592364 cites W2167627407 @default.
• W4206592364 cites W2167963794 @default.
• W4206592364 cites W2408180145 @default.
• W4206592364 cites W2615239588 @default.
• W4206592364 cites W2738180251 @default.
• W4206592364 cites W2756369214 @default.
• W4206592364 cites W2767442300 @default.
• W4206592364 cites W2789719132 @default.
• W4206592364 cites W2807943401 @default.
• W4206592364 doi "https://doi.org/10.1007/s11033-021-07106-1" @default.
• W4206592364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35064409" @default.
• W4206592364 hasPublicationYear "2022" @default.
• W4206592364 type Work @default.
• W4206592364 citedByCount "2" @default.
• W4206592364 countsByYear W42065923642022 @default.
• W4206592364 countsByYear W42065923642023 @default.
• W4206592364 crossrefType "journal-article" @default.
• W4206592364 hasAuthorship W4206592364A5002497837 @default.
• W4206592364 hasAuthorship W4206592364A5006602012 @default.
• W4206592364 hasAuthorship W4206592364A5037378495 @default.
• W4206592364 hasAuthorship W4206592364A5047157625 @default.
• W4206592364 hasAuthorship W4206592364A5047319422 @default.
• W4206592364 hasAuthorship W4206592364A5063146201 @default.
• W4206592364 hasAuthorship W4206592364A5079226794 @default.
• W4206592364 hasAuthorship W4206592364A5079355863 @default.
• W4206592364 hasBestOaLocation W42065923641 @default.
• W4206592364 hasConcept C104317684 @default.
• W4206592364 hasConcept C127561419 @default.
• W4206592364 hasConcept C145059251 @default.
• W4206592364 hasConcept C153911025 @default.
• W4206592364 hasConcept C173396325 @default.
• W4206592364 hasConcept C185592680 @default.
• W4206592364 hasConcept C190283241 @default.
• W4206592364 hasConcept C203014093 @default.
• W4206592364 hasConcept C2776415932 @default.
• W4206592364 hasConcept C2776914184 @default.
• W4206592364 hasConcept C54009773 @default.
• W4206592364 hasConcept C54355233 @default.
• W4206592364 hasConcept C55493867 @default.
• W4206592364 hasConcept C81885089 @default.
• W4206592364 hasConcept C86803240 @default.
• W4206592364 hasConcept C95444343 @default.
• W4206592364 hasConceptScore W4206592364C104317684 @default.
• W4206592364 hasConceptScore W4206592364C127561419 @default.
• W4206592364 hasConceptScore W4206592364C145059251 @default.
• W4206592364 hasConceptScore W4206592364C153911025 @default.
• W4206592364 hasConceptScore W4206592364C173396325 @default.
• W4206592364 hasConceptScore W4206592364C185592680 @default.
• W4206592364 hasConceptScore W4206592364C190283241 @default.
• W4206592364 hasConceptScore W4206592364C203014093 @default.
• W4206592364 hasConceptScore W4206592364C2776415932 @default.
• W4206592364 hasConceptScore W4206592364C2776914184 @default.
• W4206592364 hasConceptScore W4206592364C54009773 @default.
• W4206592364 hasConceptScore W4206592364C54355233 @default.
• W4206592364 hasConceptScore W4206592364C55493867 @default.
• W4206592364 hasConceptScore W4206592364C81885089 @default.
• W4206592364 hasConceptScore W4206592364C86803240 @default.
• W4206592364 hasConceptScore W4206592364C95444343 @default.
• W4206592364 hasFunder F4320321001 @default.
• W4206592364 hasFunder F4320335912 @default.

• next