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- W4206610102 endingPage "783" @default.
- W4206610102 startingPage "783" @default.
- W4206610102 abstract "Amyloid fibrils draw attention as potential novel biomaterials due to their high stability, strength, elasticity or resistance against degradation. Therefore, the controlled and fast fibrillization process is of great interest, which raises the demand for effective tools capable of regulating amyloid fibrillization. Ionic liquids (ILs) were identified as effective modulators of amyloid aggregation. The present work is focused on the study of the effect of 1-ethyl-3-methyl imidazolium-based ILs with kosmotropic anion acetate (EMIM-ac) and chaotropic cation tetrafluoroborate (EMIM-BF4) on the kinetics of lysozyme amyloid aggregation and morphology of formed fibrils using fluorescence and CD spectroscopy, differential scanning calorimetry, AFM with statistical image analysis and docking calculations. We have found that both ILs decrease the thermal stability of lysozyme and significantly accelerate amyloid fibrillization in a dose-dependent manner at concentrations of 0.5%, 1% and 5% (v/v) in conditions and time-frames when no fibrils are formed in ILs-free solvent. The effect of EMIM-BF4 is more prominent than EMIM-ac due to the different specific interactions of the anionic part with the protein surface. Although both ILs induced formation of amyloid fibrils with typical needle-like morphology, a higher variability of fibril morphology consisting of a different number of intertwining protofilaments was identified for EMIM-BF4." @default.
- W4206610102 created "2022-01-26" @default.
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- W4206610102 creator A5087870164 @default.
- W4206610102 date "2022-01-11" @default.
- W4206610102 modified "2023-09-27" @default.
- W4206610102 title "Effect of 1-Ethyl-3-methylimidazolium Tetrafluoroborate and Acetate Ionic Liquids on Stability and Amyloid Aggregation of Lysozyme" @default.
- W4206610102 cites W1560953330 @default.
- W4206610102 cites W1767963637 @default.
- W4206610102 cites W1872993917 @default.
- W4206610102 cites W1882068856 @default.
- W4206610102 cites W1967439381 @default.
- W4206610102 cites W1967516926 @default.
- W4206610102 cites W1968369580 @default.
- W4206610102 cites W1969401195 @default.
- W4206610102 cites W1970736092 @default.
- W4206610102 cites W1973739281 @default.
- W4206610102 cites W1988144809 @default.
- W4206610102 cites W1995747740 @default.
- W4206610102 cites W1996518756 @default.
- W4206610102 cites W2001019903 @default.
- W4206610102 cites W2004098528 @default.
- W4206610102 cites W2015590681 @default.
- W4206610102 cites W2021543172 @default.
- W4206610102 cites W2022315563 @default.
- W4206610102 cites W2026208456 @default.
- W4206610102 cites W2026727321 @default.
- W4206610102 cites W2047989217 @default.
- W4206610102 cites W2054687861 @default.
- W4206610102 cites W2056470073 @default.
- W4206610102 cites W2063508779 @default.
- W4206610102 cites W2064367582 @default.
- W4206610102 cites W2067214887 @default.
- W4206610102 cites W2071549479 @default.
- W4206610102 cites W2073410249 @default.
- W4206610102 cites W2075982275 @default.
- W4206610102 cites W2076468390 @default.
- W4206610102 cites W2076705627 @default.
- W4206610102 cites W2077009055 @default.
- W4206610102 cites W2079386876 @default.
- W4206610102 cites W2086258145 @default.
- W4206610102 cites W2088395760 @default.
- W4206610102 cites W2091938868 @default.
- W4206610102 cites W2092225052 @default.
- W4206610102 cites W2096425372 @default.
- W4206610102 cites W2105668062 @default.
- W4206610102 cites W2109749561 @default.
- W4206610102 cites W2117118343 @default.
- W4206610102 cites W2119262627 @default.
- W4206610102 cites W2121440274 @default.
- W4206610102 cites W2128595832 @default.
- W4206610102 cites W2137328098 @default.
- W4206610102 cites W2142621641 @default.
- W4206610102 cites W2146656482 @default.
- W4206610102 cites W2150842582 @default.
- W4206610102 cites W2153526379 @default.
- W4206610102 cites W2164871309 @default.
- W4206610102 cites W2165186407 @default.
- W4206610102 cites W2165565773 @default.
- W4206610102 cites W2279156922 @default.
- W4206610102 cites W2322090060 @default.
- W4206610102 cites W2331304475 @default.
- W4206610102 cites W2529964895 @default.
- W4206610102 cites W2580018907 @default.
- W4206610102 cites W2745101499 @default.
- W4206610102 cites W2765282457 @default.
- W4206610102 cites W2789853984 @default.
- W4206610102 cites W2790600623 @default.
- W4206610102 cites W2800151452 @default.
- W4206610102 cites W2805496732 @default.
- W4206610102 cites W2885242008 @default.
- W4206610102 cites W2891535956 @default.
- W4206610102 cites W2911834686 @default.
- W4206610102 cites W2912033397 @default.
- W4206610102 cites W2924950519 @default.
- W4206610102 cites W2965202240 @default.
- W4206610102 cites W2981137029 @default.
- W4206610102 cites W3012664167 @default.
- W4206610102 cites W3017260797 @default.
- W4206610102 cites W3023319571 @default.
- W4206610102 cites W3048619486 @default.
- W4206610102 cites W4248104288 @default.
- W4206610102 cites W597893155 @default.
- W4206610102 doi "https://doi.org/10.3390/ijms23020783" @default.
- W4206610102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35054967" @default.
- W4206610102 hasPublicationYear "2022" @default.
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