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• W4206624871 abstract "<b><i>Objectives:</i></b> Although splenectomy has long been second-line option for immune thrombocytopenia (ITP) patients, an indicator that reliably predicts the efficacy of splenectomy is still being explored. We investigated the treatment outcomes of splenectomy as a second-line therapy for relapsed/refractory ITP according to first-line intravenous immunoglobulin (IVIG) responses. <b><i>Methods:</i></b> Fifty-two adult patients treated with splenectomy as second-line therapy for ITP between 2009 and 2019 were included, and they were classified according to first-line IVIG responses (no response to IVIG: nonresponders; only transient IVIG response shorter than 4 weeks: poor responders; IVIG response for a longer period; stable responders). The efficacy of splenectomy was analyzed in the three subgroups. <b><i>Results:</i></b> Of the 52 patients, 10 were IVIG nonresponders, 34 were poor responders, and the remaining 8 were stable responders. Response to splenectomy was observed in 50.0% of IVIG nonresponders, 94.1% of poor responders, and 100% of stable responders (<i>p</i> = 0.0030). Among the 45 patients who responded to splenectomy, 51.1% relapsed subsequently, and a significantly lower relapse rate was noted in the stable IVIG responders (12.5%, <i>p</i> = 0.0220) than in nonresponders (60.0%) and poor responders (59.4%). <b><i>Conclusions:</i></b> First-line IVIG response is indicated as a useful predictive factor for response to splenectomy." @default.
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• W4206624871 date "2022-01-01" @default.
• W4206624871 modified "2023-10-18" @default.
• W4206624871 title "Splenectomy Outcomes in Relapsed or Refractory Immune Thrombocytopenia according to First-Line Intravenous Immunoglobulin Response" @default.
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• W4206624871 doi "https://doi.org/10.1159/000521912" @default.
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