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- W4206634583 abstract "Annals of NeurologyVolume 42, Issue 5 p. 747-755 Original Article Entacapone improves motor fluctuations in levodopa- treated Parkinson's disease patients First published: 08 October 2004 https://doi.org/10.1002/ana.410420511Citations: 237AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Abstract Motor fluctuations associated with levodopa therapy are common problems encountered in the long-term treatment of Parkinson's disease (PD). Entacapone, a peripherally acting, reversible inhibitor of catechol-O-methyltransferase, slows the elimination of levodopa in humans by reducing the formation of 3-O-methyldopa. We conducted a placebo-controlled, double-blind, parallel-group, multicenter trial of entacapone in PD patients with motor fluctuations. Two hundred five patients were randomized to receive either entacapone 200 mg or matching placebo with each dose of levodopa and were followed for 24 weeks. The primary measure of efficacy was the change in percentage of “on” time (relief of parkinsonism) while awake, as recorded by subjects at home in diaries completed at 30-minute intervals. At baseline, patients averaged approximately 10 hours of “on” time per day while awake (60.5% “on” time), and entacapone treatment increased the percent “on” time by 5.0 percentage points. The effect of entacapone was more prominent in patients with a smaller percent “on” time (<55%) at baseline, and increased as the day wore on. Entacapone is effective at increasing the duration of response to levodopa and at relieving parkinsonism in patients experiencing motor flucturations and was well tolerated during the 24 weeks of treatment. Citing Literature Volume42, Issue5November 1997Pages 747-755 RelatedInformation" @default.
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- W4206634583 title "Entacapone improves motor fluctuations in levodopa- treated Parkinson's disease patients" @default.
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- W4206634583 doi "https://doi.org/10.1002/ana.410420511" @default.
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