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- W4206640567 abstract "In patients with familial hypercholesterolemia (FH) the exposure of very high LDL-C concentration and cumulative LDL-C level (cum LDL-C) can play a significant role in the prognosis.to analyze the contribution of cum LDL-C for all life and the index cum LDL-C/age to the development of coronary heart disease (CHD), myocardial infarction (MI), and a combined end point: MI, stroke, unstable angina in FH patients.188 patients (mean age 49.2 years, males 45.7%) with FH were examined (Dutch Lipid Clinic Criteria). We had evaluated cumulative LDL-C and index cum DL-C/age along with other classical risk factors. Cum LDL-C was calculated as LDL-Cmax × (age at initiating of hypolipidemic therapy) + LDL-C at inclusion age at initiation/correction therapy). Cumulative LDL-C and cum LDL-C/age were calculated as the ratio cum LDL-C to age. The follow-up period was 5.4 (from 3 to 10) years.The index cum LDL-C/age was higher in patients with CHD 58.7 ± 10.4 mmol/L/years vs. 40.1 ± 11.7 mmol/L/years in patients without CHD (p < 0.001). According to our data based on the results of the logistic regression analysis in patients with FH, cumulative LDL-C and the cumulative index cum LDL-C/age played a strong predictive role in the development of CHD in FH patients; it was greater than the role of TC and LDL-C concentrations. We present ROC curves for CHD, MI and combined end point in FH patients, and a prognostic scale for CHD development, which is based on classical cardiovascular risk factors.cumulative LDL-C level plays an important role in the development of CHD in FH patients." @default.
- W4206640567 created "2022-01-26" @default.
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- W4206640567 date "2022-01-07" @default.
- W4206640567 modified "2023-10-14" @default.
- W4206640567 title "The Role of Cumulative LDL Cholesterol in Cardiovascular Disease Development in Patients with Familial Hypercholesterolemia" @default.
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- W4206640567 doi "https://doi.org/10.3390/jpm12010071" @default.
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