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- W4206642020 endingPage "189" @default.
- W4206642020 startingPage "175" @default.
- W4206642020 abstract "Oral drug delivery systems (DDS) targeting lymphocytes in intestinal lymphatic vessels, ducts, and nodes are useful for treating diverse diseases. The intestinal lymph harbors numerous lymphocyte subsets, and DDS containing lipids such as triglycerides and fatty acids can deliver drugs to the lymph through the chylomicron pathway. DDS are efficient, thus allowing the administration of reduced drug doses, which mitigate systemic adverse effects. Here we review orally administered lipid formulations comprising oil solutions, suspensions, micro/nanoemulsions, self-micro/nano emulsifying DDS, liposomes, micelles, solid lipid nanoparticles, and nanostructured lipid carriers for targeting drugs to the lymph. We first describe the structures of lymphatic vessels and lymph nodes and the oral absorption of lipids and drugs into the intestinal lymph. We next summarize the effects of the properties and amounts of lipids and drugs delivered into the lymph and lymphocytes, as well as their effects on drug delivery ratios of lymph to blood. Finally, we describe lymphatic DDS containing saquinavir, tacrolimus, and methotrexate, and their potency that reduces drug concentrations in blood, which are associated with systemic adverse effects." @default.
- W4206642020 created "2022-01-26" @default.
- W4206642020 creator A5004653171 @default.
- W4206642020 creator A5045091020 @default.
- W4206642020 creator A5047686405 @default.
- W4206642020 creator A5063194937 @default.
- W4206642020 date "2022-02-07" @default.
- W4206642020 modified "2023-09-27" @default.
- W4206642020 title "Drug delivery to the intestinal lymph by oral formulations" @default.
- W4206642020 cites W105785269 @default.
- W4206642020 cites W1482561213 @default.
- W4206642020 cites W1485145206 @default.
- W4206642020 cites W1574073898 @default.
- W4206642020 cites W1579998928 @default.
- W4206642020 cites W1758993921 @default.
- W4206642020 cites W1911274345 @default.
- W4206642020 cites W1934805819 @default.
- W4206642020 cites W1966796681 @default.
- W4206642020 cites W1972856288 @default.
- W4206642020 cites W1973646980 @default.
- W4206642020 cites W1974803402 @default.
- W4206642020 cites W1976104973 @default.
- W4206642020 cites W1976546786 @default.
- W4206642020 cites W1979981548 @default.
- W4206642020 cites W1984326299 @default.
- W4206642020 cites W1988383608 @default.
- W4206642020 cites W1989680746 @default.
- W4206642020 cites W1991943948 @default.
- W4206642020 cites W1995269166 @default.
- W4206642020 cites W1996463858 @default.
- W4206642020 cites W1996633290 @default.
- W4206642020 cites W2007324134 @default.
- W4206642020 cites W2011698393 @default.
- W4206642020 cites W2013129339 @default.
- W4206642020 cites W2013355011 @default.
- W4206642020 cites W2013723299 @default.
- W4206642020 cites W2014144492 @default.
- W4206642020 cites W2015661017 @default.
- W4206642020 cites W2019124020 @default.
- W4206642020 cites W2020742497 @default.
- W4206642020 cites W2021993298 @default.
- W4206642020 cites W2028403331 @default.
- W4206642020 cites W2033795330 @default.
- W4206642020 cites W2036270563 @default.
- W4206642020 cites W2037759720 @default.
- W4206642020 cites W2038084720 @default.
- W4206642020 cites W2039487077 @default.
- W4206642020 cites W2040003502 @default.
- W4206642020 cites W2041933045 @default.
- W4206642020 cites W2047749369 @default.
- W4206642020 cites W2048420511 @default.
- W4206642020 cites W2050510112 @default.
- W4206642020 cites W2052431377 @default.
- W4206642020 cites W2054727211 @default.
- W4206642020 cites W2056750033 @default.
- W4206642020 cites W2056869363 @default.
- W4206642020 cites W2059453747 @default.
- W4206642020 cites W2062884253 @default.
- W4206642020 cites W2071465678 @default.
- W4206642020 cites W2073540513 @default.
- W4206642020 cites W2081210808 @default.
- W4206642020 cites W2081926138 @default.
- W4206642020 cites W2082081389 @default.
- W4206642020 cites W2083117601 @default.
- W4206642020 cites W2083627546 @default.
- W4206642020 cites W2091872697 @default.
- W4206642020 cites W2094735667 @default.
- W4206642020 cites W2099636850 @default.
- W4206642020 cites W2111849358 @default.
- W4206642020 cites W2119087638 @default.
- W4206642020 cites W2120241355 @default.
- W4206642020 cites W2120277402 @default.
- W4206642020 cites W2126462892 @default.
- W4206642020 cites W2126554641 @default.
- W4206642020 cites W2130985118 @default.
- W4206642020 cites W2133061356 @default.
- W4206642020 cites W2137333865 @default.
- W4206642020 cites W2138284504 @default.
- W4206642020 cites W2146516774 @default.
- W4206642020 cites W2150604710 @default.
- W4206642020 cites W2154386428 @default.
- W4206642020 cites W2155197175 @default.
- W4206642020 cites W2165946092 @default.
- W4206642020 cites W2204416339 @default.
- W4206642020 cites W2210546998 @default.
- W4206642020 cites W2225842963 @default.
- W4206642020 cites W2253498406 @default.
- W4206642020 cites W2315127988 @default.
- W4206642020 cites W2319203547 @default.
- W4206642020 cites W2409229404 @default.
- W4206642020 cites W2507558963 @default.
- W4206642020 cites W2556998674 @default.
- W4206642020 cites W2591861763 @default.
- W4206642020 cites W2606614729 @default.
- W4206642020 cites W2732637235 @default.
- W4206642020 cites W2745504255 @default.
- W4206642020 cites W2884347405 @default.
- W4206642020 cites W2896790799 @default.