FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206644361> ?p ?o ?g. }

• W4206644361 endingPage "101366" @default.
• W4206644361 startingPage "101366" @default.
• W4206644361 abstract "Oxidative stress has close relationship with the progression of osteoarthritis and thus is an important therapeutic target. The use of antioxidants alone has common disadvantages such as low bioavailability, poor stability, and rapid joint clearance or toxicity at high concentrations. To achieve both reactive oxygen species (ROS) responsive scavenging ability and drug targeted delivery ability, a novel polymer (PEG-PTK-PEG) was synthesized through a simple and direct reaction between polythioketal (PTK) and m-PEG-acrylate. In addition to excellent mechanical properties and high drug loading capacity, the degradation products of PEG-PTK-PEG responding to the ROS accumulating microenvironment also have excellent biocompatibility and extremely low toxicity. Further, the PEG-PTK-PEG nanoparticles (NPs) loaded with astaxanthin (ASTA), which is an antioxidant with high biological safety, could effectively reduce ROS expression and release ASTA slowly and accurately in the area of high ROS expression as a result of the polymer degradation. In the OA model, the [email protected] could effectively inhibit the expression of ROS, thereby downregulating the MAPK signaling pathway and inducing the conversion of macrophages from the M1 phenotype to the M2 phenotype. The synergistic effect of PEG-PTK-PEG's ROS-responsive drug delivery ability and ROS scavenging ability significantly promoted the therapeutic effect of OA, providing a new and effective strategy for the clinical treatment of OA." @default.
• W4206644361 created "2022-01-25" @default.
• W4206644361 creator A5001585514 @default.
• W4206644361 creator A5016906085 @default.
• W4206644361 creator A5031895507 @default.
• W4206644361 creator A5032553354 @default.
• W4206644361 creator A5033905362 @default.
• W4206644361 creator A5042657313 @default.
• W4206644361 creator A5049317673 @default.
• W4206644361 creator A5056530872 @default.
• W4206644361 creator A5079448948 @default.
• W4206644361 creator A5091883923 @default.
• W4206644361 date "2022-03-01" @default.
• W4206644361 modified "2023-10-13" @default.
• W4206644361 title "The ROS‐responsive scavenger with intrinsic antioxidant capability and enhanced immunomodulatory effects for cartilage protection and osteoarthritis remission" @default.
• W4206644361 cites W1219376250 @default.
• W4206644361 cites W1812173421 @default.
• W4206644361 cites W1971496705 @default.
• W4206644361 cites W1981306734 @default.
• W4206644361 cites W1987223440 @default.
• W4206644361 cites W2001213139 @default.
• W4206644361 cites W2011227409 @default.
• W4206644361 cites W2020627250 @default.
• W4206644361 cites W2030582052 @default.
• W4206644361 cites W2033379487 @default.
• W4206644361 cites W2048223574 @default.
• W4206644361 cites W2049774926 @default.
• W4206644361 cites W2063795634 @default.
• W4206644361 cites W2085111729 @default.
• W4206644361 cites W2087492003 @default.
• W4206644361 cites W2092282157 @default.
• W4206644361 cites W2099427592 @default.
• W4206644361 cites W2120126495 @default.
• W4206644361 cites W2125022259 @default.
• W4206644361 cites W2132605158 @default.
• W4206644361 cites W2133452519 @default.
• W4206644361 cites W2134945818 @default.
• W4206644361 cites W2153451178 @default.
• W4206644361 cites W2206751744 @default.
• W4206644361 cites W2227341519 @default.
• W4206644361 cites W2235731915 @default.
• W4206644361 cites W2240820333 @default.
• W4206644361 cites W2270756512 @default.
• W4206644361 cites W2416125307 @default.
• W4206644361 cites W2507683743 @default.
• W4206644361 cites W2513471047 @default.
• W4206644361 cites W2577396496 @default.
• W4206644361 cites W2582637155 @default.
• W4206644361 cites W259194763 @default.
• W4206644361 cites W2594190200 @default.
• W4206644361 cites W2740118744 @default.
• W4206644361 cites W2746021105 @default.
• W4206644361 cites W2771197141 @default.
• W4206644361 cites W2775320826 @default.
• W4206644361 cites W2792408942 @default.
• W4206644361 cites W2797448045 @default.
• W4206644361 cites W2800248573 @default.
• W4206644361 cites W2808863657 @default.
• W4206644361 cites W2888339723 @default.
• W4206644361 cites W2889191136 @default.
• W4206644361 cites W2897673143 @default.
• W4206644361 cites W2898015119 @default.
• W4206644361 cites W2900550641 @default.
• W4206644361 cites W2913979364 @default.
• W4206644361 cites W2920290417 @default.
• W4206644361 cites W2920324197 @default.
• W4206644361 cites W2923441281 @default.
• W4206644361 cites W2947510286 @default.
• W4206644361 cites W2949229271 @default.
• W4206644361 cites W2972832815 @default.
• W4206644361 cites W2989666439 @default.
• W4206644361 cites W3000734109 @default.
• W4206644361 cites W3000832251 @default.
• W4206644361 cites W3008951161 @default.
• W4206644361 cites W3139450778 @default.
• W4206644361 cites W3158718410 @default.
• W4206644361 cites W3196434765 @default.
• W4206644361 cites W4211067786 @default.
• W4206644361 doi "https://doi.org/10.1016/j.apmt.2022.101366" @default.
• W4206644361 hasPublicationYear "2022" @default.
• W4206644361 type Work @default.
• W4206644361 citedByCount "6" @default.
• W4206644361 countsByYear W42066443612022 @default.
• W4206644361 countsByYear W42066443612023 @default.
• W4206644361 crossrefType "journal-article" @default.
• W4206644361 hasAuthorship W4206644361A5001585514 @default.
• W4206644361 hasAuthorship W4206644361A5016906085 @default.
• W4206644361 hasAuthorship W4206644361A5031895507 @default.
• W4206644361 hasAuthorship W4206644361A5032553354 @default.
• W4206644361 hasAuthorship W4206644361A5033905362 @default.
• W4206644361 hasAuthorship W4206644361A5042657313 @default.
• W4206644361 hasAuthorship W4206644361A5049317673 @default.
• W4206644361 hasAuthorship W4206644361A5056530872 @default.
• W4206644361 hasAuthorship W4206644361A5079448948 @default.
• W4206644361 hasAuthorship W4206644361A5091883923 @default.
• W4206644361 hasBestOaLocation W42066443611 @default.
• W4206644361 hasConcept C10138342 @default.
• W4206644361 hasConcept C12554922 @default.

• next