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- W4206647157 abstract "Male gametes originate from a small population of spermatogonial stem cells (SSCs). These cells are believed to divide infinitely and to support spermatogenesis throughout life in the male. Here, we developed a strategy for the establishment of SSC lines from embryonic stem (ES) cells. These cells are able to undergo meiosis, are able to generate haploid male gametes in vitro, and are functional, as shown by fertilization after intracytoplasmic injection into mouse oocytes. Resulting two-cell embryos were transferred into oviducts, and live mice were born. Six of seven animals developed to adult mice. This is a clear indication that male gametes derived in vitro from ES cells by this strategy are able to induce normal fertilization and development. Our approach provides an accessible in vitro model system for studies of mammalian gametogenesis, as well as for the development of new strategies for the generation of transgenic mice and treatment of infertility. PMID: 16824959" @default.
- W4206647157 created "2022-01-26" @default.
- W4206647157 creator A5033872453 @default.
- W4206647157 date "2006-07-11" @default.
- W4206647157 modified "2023-10-03" @default.
- W4206647157 title "Faculty Opinions recommendation of In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice." @default.
- W4206647157 doi "https://doi.org/10.3410/f.1033193.375169" @default.
- W4206647157 hasPublicationYear "2006" @default.
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