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- W4206652778 abstract "<sec> <title>BACKGROUND</title> Cervical cancer is among the most common type of cancers in women and is associated with human papillomavirus (HPV) infection. </sec> <sec> <title>OBJECTIVE</title> The link between cervical cancer and high-risk HPV infection has been well documented, although the effect of simultaneous infection with high- and low-risk HPV or low-risk HPV alone on the risk of developing cervical malignancy is remained to be unanswered in guideline </sec> <sec> <title>METHODS</title> We have investigated the association of high and low-risk HPVs (HR or LR) genotype with cervical carcinoma risk, as well as pathological and cytological information in cases recruited from a population-based cohort study of 790 patients. </sec> <sec> <title>RESULTS</title> The percentage of HR+LR and HR-HPV16/18 were 9.30% and 11.20% in class II, 7.15% and 7.10% in class IV and 7.15% and 5.80% in As-CUS smears. Interestingly concurrent infection with HR-HPV and LR-HPV types led to a notable decline in the risk of developing malignancy in comparison with the high-risk group (OR=0.3 (0.098-0.925), p-value=0.04). The percentage of individuals with cervical malignancy was 10.2% and 28.2% within the co-infected and the HR-HPV participants. </sec> <sec> <title>CONCLUSIONS</title> Our finding demonstrated that simultaneous infection with high- and low-risk HPV reduces the risk of cervical malignancy. </sec>" @default.
- W4206652778 created "2022-01-25" @default.
- W4206652778 creator A5071764880 @default.
- W4206652778 date "2021-12-28" @default.
- W4206652778 modified "2023-09-27" @default.
- W4206652778 title "Interaction of High- and Low-Risk human papillomavirus genotypes is associated with a reduced risk of developing cervical cancer (Preprint)" @default.
- W4206652778 doi "https://doi.org/10.2196/preprints.36017" @default.
- W4206652778 hasPublicationYear "2021" @default.
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