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- W4206656285 abstract "Abstract A robust synthesis of Soai‐type pyrimidine aldehydes proceeds in good to high yields by controlled formation and quenching of a lithiated pyrimidine intermediate. The alkyne‐substituted bromopyrimidine, furnished by Sonogashira cross‐coupling, underwent a Barbier‐type halogen‐lithium exchange to form a transient pyrimidinyl lithium species. The rate of n ‐BuLi addition was optimized to better synchronize with the addition to ethyl formate, in order to achieve consistently high yields of 2‐alkylpyrimdinecarboxaldehydes for use in autocatalysis or as functionalized synthons." @default.
- W4206656285 created "2022-01-26" @default.
- W4206656285 creator A5043771264 @default.
- W4206656285 creator A5091750459 @default.
- W4206656285 date "2022-01-27" @default.
- W4206656285 modified "2023-09-27" @default.
- W4206656285 title "Robust and Scalable Synthesis of Soai Aldehydes via Improved Barbier‐type Halogen–lithium Exchange" @default.
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- W4206656285 doi "https://doi.org/10.1002/ajoc.202100787" @default.
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