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- W4206667531 endingPage "66" @default.
- W4206667531 startingPage "66" @default.
- W4206667531 abstract "Despite the scientific advancements, organophosphate (OP) poisoning continues to be a major threat to humans, accounting for nearly one million poisoning cases every year leading to at least 20,000 deaths worldwide. Oximes represent the most important class in medicinal chemistry, renowned for their widespread applications as OP antidotes, drugs and intermediates for the synthesis of several pharmacological derivatives. Common oxime based reactivators or nerve antidotes include pralidoxime, obidoxime, HI-6, trimedoxime and methoxime, among which pralidoxime is the only FDA-approved drug. Cephalosporins are β-lactam based antibiotics and serve as widely acclaimed tools in fighting bacterial infections. Oxime based cephalosporins have emerged as an important class of drugs with improved efficacy and a broad spectrum of anti-microbial activity against Gram-positive and Gram-negative pathogens. Among the several oxime based derivatives, cefuroxime, ceftizoxime, cefpodoxime and cefmenoxime are the FDA approved oxime-based antibiotics. Given the pharmacological significance of oximes, in the present paper, we put together all the FDA-approved oximes and discuss their mechanism of action, pharmacokinetics and synthesis." @default.
- W4206667531 created "2022-01-25" @default.
- W4206667531 creator A5020567148 @default.
- W4206667531 creator A5041193290 @default.
- W4206667531 creator A5085074627 @default.
- W4206667531 date "2022-01-04" @default.
- W4206667531 modified "2023-10-14" @default.
- W4206667531 title "FDA-Approved Oximes and Their Significance in Medicinal Chemistry" @default.
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