FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206686136> ?p ?o ?g. }

• W4206686136 endingPage "682" @default.
• W4206686136 startingPage "676" @default.
• W4206686136 abstract "There are numerous scientific studies of recurrent miscarriage (RM) with possible causes, such as fetal chromosomal abnormalities, infectious agents, adverse environmental factors, bad habits, anatomical defects, thrombophilic disorders, etc. However, RM causes in 50% of cases remain unknown. These RM cases do not have any explainable etiology, and they require in-depth etiopathogenesis study, thus they are considered idiopathic RM. The purpose of this research is to study polymorphisms relationship of the immune response genes CX3CR1 (rs3732379, Val249Ile), CTLA4 (rs3087243, CT60 G/A), and HLA DQA1, DQB1, DRB1 (major histocompatibility complex, class II) with the idiopathic form of recurrent miscarriage (iRM) development in Kazakh population. Independent replicative TagMan genotyping for 302 patients with iRM and 300 women with normal reproduction was performed. It has been shown that carriage of unfavorable genotypes (Val/Ile, Val/Val) by the Val249Ile polymorphism of the CX3CR1 gene increases the risk of developing iRM by 1.43 times. Search for associations of genes allelic variants of HLA class 2 complex with iRM revealed *501 allele in DQA1 locus, *0301 in DQB1 locus, *10, *12, *15, *16 alleles in DRB1 locus, which increases the risk of developing iRM in Kazakh population with OR from 1.34 to 4.5. As a result of the study, obtained highly significant associations of immune response genes with the development of iRM in the Kazakh population indicate the possible involvement of the immune system interaction of mother cells with syncytiotrophoblast, which is realized by vascularization defects, defective embryo implantation, and leads to early pregnancies' termination." @default.
• W4206686136 created "2022-01-25" @default.
• W4206686136 creator A5010785923 @default.
• W4206686136 creator A5013170556 @default.
• W4206686136 creator A5052913690 @default.
• W4206686136 creator A5075028597 @default.
• W4206686136 creator A9999999999 @default.
• W4206686136 date "2021-01-01" @default.
• W4206686136 modified "2023-10-18" @default.
• W4206686136 title "Immunogenetic aspects of idiopathic recurrent miscarriage in the Kazakh population" @default.
• W4206686136 cites W124830075 @default.
• W4206686136 cites W1967178172 @default.
• W4206686136 cites W1973028577 @default.
• W4206686136 cites W1980559240 @default.
• W4206686136 cites W1998086182 @default.
• W4206686136 cites W2020067522 @default.
• W4206686136 cites W2046914934 @default.
• W4206686136 cites W2060580894 @default.
• W4206686136 cites W2065488982 @default.
• W4206686136 cites W2091542976 @default.
• W4206686136 cites W2094000075 @default.
• W4206686136 cites W2107859864 @default.
• W4206686136 cites W2117289398 @default.
• W4206686136 cites W2125332209 @default.
• W4206686136 cites W2129581460 @default.
• W4206686136 cites W2133785492 @default.
• W4206686136 cites W2156990334 @default.
• W4206686136 cites W2161633633 @default.
• W4206686136 cites W2166813516 @default.
• W4206686136 cites W2272806623 @default.
• W4206686136 cites W2333214860 @default.
• W4206686136 cites W2372226205 @default.
• W4206686136 cites W2372485871 @default.
• W4206686136 cites W2471048467 @default.
• W4206686136 cites W2510993151 @default.
• W4206686136 cites W2614898738 @default.
• W4206686136 cites W2884077110 @default.
• W4206686136 cites W2905131280 @default.
• W4206686136 cites W2917468820 @default.
• W4206686136 cites W2922511823 @default.
• W4206686136 cites W2966492262 @default.
• W4206686136 cites W3032948126 @default.
• W4206686136 cites W3039684762 @default.
• W4206686136 cites W3046443256 @default.
• W4206686136 cites W3129061381 @default.
• W4206686136 cites W4237134803 @default.
• W4206686136 cites W4253046392 @default.
• W4206686136 cites W4254259382 @default.
• W4206686136 doi "https://doi.org/10.25122/jml-2021-0063" @default.
• W4206686136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35027970" @default.
• W4206686136 hasPublicationYear "2021" @default.
• W4206686136 type Work @default.
• W4206686136 citedByCount "3" @default.
• W4206686136 countsByYear W42066861362022 @default.
• W4206686136 countsByYear W42066861362023 @default.
• W4206686136 crossrefType "journal-article" @default.
• W4206686136 hasAuthorship W4206686136A5010785923 @default.
• W4206686136 hasAuthorship W4206686136A5013170556 @default.
• W4206686136 hasAuthorship W4206686136A5052913690 @default.
• W4206686136 hasAuthorship W4206686136A5075028597 @default.
• W4206686136 hasAuthorship W4206686136A9999999999 @default.
• W4206686136 hasBestOaLocation W42066861361 @default.
• W4206686136 hasConcept C104317684 @default.
• W4206686136 hasConcept C135763542 @default.
• W4206686136 hasConcept C138885662 @default.
• W4206686136 hasConcept C147483822 @default.
• W4206686136 hasConcept C180754005 @default.
• W4206686136 hasConcept C188280979 @default.
• W4206686136 hasConcept C203014093 @default.
• W4206686136 hasConcept C2781297163 @default.
• W4206686136 hasConcept C2908647359 @default.
• W4206686136 hasConcept C31467283 @default.
• W4206686136 hasConcept C41895202 @default.
• W4206686136 hasConcept C54355233 @default.
• W4206686136 hasConcept C71924100 @default.
• W4206686136 hasConcept C84597430 @default.
• W4206686136 hasConcept C86803240 @default.
• W4206686136 hasConcept C99454951 @default.
• W4206686136 hasConceptScore W4206686136C104317684 @default.
• W4206686136 hasConceptScore W4206686136C135763542 @default.
• W4206686136 hasConceptScore W4206686136C138885662 @default.
• W4206686136 hasConceptScore W4206686136C147483822 @default.
• W4206686136 hasConceptScore W4206686136C180754005 @default.
• W4206686136 hasConceptScore W4206686136C188280979 @default.
• W4206686136 hasConceptScore W4206686136C203014093 @default.
• W4206686136 hasConceptScore W4206686136C2781297163 @default.
• W4206686136 hasConceptScore W4206686136C2908647359 @default.
• W4206686136 hasConceptScore W4206686136C31467283 @default.
• W4206686136 hasConceptScore W4206686136C41895202 @default.
• W4206686136 hasConceptScore W4206686136C54355233 @default.
• W4206686136 hasConceptScore W4206686136C71924100 @default.
• W4206686136 hasConceptScore W4206686136C84597430 @default.
• W4206686136 hasConceptScore W4206686136C86803240 @default.
• W4206686136 hasConceptScore W4206686136C99454951 @default.
• W4206686136 hasIssue "5" @default.
• W4206686136 hasLocation W42066861361 @default.
• W4206686136 hasLocation W42066861362 @default.
• W4206686136 hasLocation W42066861363 @default.

• next