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• W4206688478 abstract "Kv1.5 potassium channel, encoded by KCNA5, is a promising target for the treatment of atrial fibrillation, one of the common arrhythmia. A new series of arylmethylpiperidines derivatives based on DDO-02001 were synthesised and evaluated for their ability to inhibit Kv1.5 channel. Among them, compound DDO-02005 showed good inhibitory activity (IC50 = 0.72 μM), preferable anti-arrhythmic effects and favoured safety. These results indicate that DDO-02005 can be a promising Kv1.5 inhibitor for further studies." @default.
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• W4206688478 date "2022-01-10" @default.
• W4206688478 modified "2023-10-14" @default.
• W4206688478 title "Design, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors" @default.
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• W4206688478 doi "https://doi.org/10.1080/14756366.2021.2018683" @default.
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