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- W4206703922 abstract "Abstract Background New amphiphilic distyrylbenzene derivatives have been developed that target both the soluble Aβ oligomers and amyloid plaques in Alzheimer's disease (AD), as well as the extracellular p‐tau aggregates, Aβ‐mediated oxidative stress, and neuroinflammation. Method We have developed a novel amphiphilic distyrylbenzene derivative that exhibits high binding affinity for Aβ aggregates ‐ especially the Aβ oligomers, and a series of ex vivo and in vivo immunostaining and imaging studies were employed to probe the beneficial properties of this potential therapeutic agent. Result Upon treatment of 5×FAD mice with an amphiphilic distyrylbenzene derivative, fluorescence imaging of the brain sections shows that this compound can easily penetrate the blood‐brain‐barrier and selectively bind to the Aβ oligomers, as confirmed by the colocalization with an Aβ oligomer‐specific antibody. Furthermore, when comparing the MFC‐treated mice vs. the vehicle‐treated mice, the total amount of Aβ species and the associated p‐tau aggregates was significantly decreased by up to 70%, along with a significant reduction in the amount of activated microglia. Conclusion The amphiphilic distyrylbenzene compound reported herein can attenuate the formation of amyloid plaques and associated p‐tau aggregates, while also reducing the microglia‐mediated neuroinflammatory response, which is uncommon among the previously reported amyloid‐targeting chemical agents." @default.
- W4206703922 created "2022-01-25" @default.
- W4206703922 creator A5021486550 @default.
- W4206703922 date "2021-12-01" @default.
- W4206703922 modified "2023-10-17" @default.
- W4206703922 title "Amphiphilic distyrylbenzene derivatives as potential therapeutic and imaging agents for the soluble amyloid‐β oligomers in Alzheimer’s disease" @default.
- W4206703922 doi "https://doi.org/10.1002/alz.056375" @default.
- W4206703922 hasPublicationYear "2021" @default.
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