FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206720207> ?p ?o ?g. }

• W4206720207 endingPage "418" @default.
• W4206720207 startingPage "412" @default.
• W4206720207 abstract "<b><i>Introduction:</i></b> Hypoxia-inducible factor prolyl hydroxylase domain inhibitors (HIF-PHI) are a new treatment for renal anemia. HIF-PHI is believed to increase iron usage to improve availability of iron for erythropoiesis. Therefore, there is concern that HIF-PHI might be prone to iron deficiency and that thrombosis might be induced by increased platelet and transferrin levels due to this iron deficiency. <b><i>Methods:</i></b> Relationship of iron-related factors with platelet count (PLT) and total iron-binding capacity (TIBC; which reflects the transferrin level) were examined in 29 patients who were treated with darbepoetin alfa (DA) and then switched to roxadustat (Rox). To determine how changes in PLT and TIBC related to changes in iron-related factors, univariable and multivariable linear regression models were applied. To examine what iron-related factors on Day 0 influenced change in PLT, we used receiver operating characteristic (ROC) curves and logistic regression analysis for a rate of change in PLT ≤0% as the endpoint. Logistic regression analysis was performed with the reference group having serum ferritin (s-ft) or Transferrin saturation below the corresponding cutoff value (low vs. high). <b><i>Results:</i></b> Multivariable analysis showed significant positive correlations between the rate of change in PLT and the change in s-ft and red blood cells (RBC) count {β-coefficients; 0.40 [95% confidence interval (CI): 0.17–0.62], <i>p</i> = 0.001} (β-coefficients; 30.45 [95% CI: 10.90–50.00], <i>p</i> = 0.004). The rate of change in TIBC was significantly positively correlated with only the change in RBC count. The ROC showed a significant cutoff value for s-ft of 77.2 ng/mL (sensitivity 63.6%, specificity 83.3%, area under the curve 0.76, 95% CI 0.55–0.96). Multivariable logistic regression also showed that only high s-ft was significantly elevated (9.46, 95% CI 1.42–63.30, <i>p</i> = 0.020). <b><i>Conclusions:</i></b> This study showed that changes in PLT were correlated with s-ft and amount of hematopoiesis. This suggests that an increase in PLT due to iron levels is less likely when s-ft is 77.2 ng/mL or higher at the time of switching from DA to Rox. In contrast, TIBC was only related to hematopoiesis in these patients. Control of s-ft before initiation of HIF-PHI treatment and gradual hematopoiesis might reduce the risk of thrombosis when switching from erythropoiesis-stimulating agents to HIF-PHI." @default.
• W4206720207 created "2022-01-26" @default.
• W4206720207 creator A5013245218 @default.
• W4206720207 creator A5037218495 @default.
• W4206720207 creator A5076304295 @default.
• W4206720207 creator A5083301096 @default.
• W4206720207 date "2022-01-01" @default.
• W4206720207 modified "2023-10-03" @default.
• W4206720207 title "Threshold of Serum Ferritin to Discriminate against Those at Greater Risk of Platelet Increase during Treatment with Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Inhibitor" @default.
• W4206720207 cites W1571264337 @default.
• W4206720207 cites W1966776357 @default.
• W4206720207 cites W1970045461 @default.
• W4206720207 cites W1975241303 @default.
• W4206720207 cites W1991047577 @default.
• W4206720207 cites W2033648279 @default.
• W4206720207 cites W2035772105 @default.
• W4206720207 cites W2122513632 @default.
• W4206720207 cites W2418391351 @default.
• W4206720207 cites W2727662168 @default.
• W4206720207 cites W2981079549 @default.
• W4206720207 cites W3003297516 @default.
• W4206720207 cites W3042922268 @default.
• W4206720207 cites W3080144119 @default.
• W4206720207 cites W3089041918 @default.
• W4206720207 cites W3167359809 @default.
• W4206720207 cites W3201474187 @default.
• W4206720207 cites W4233089953 @default.
• W4206720207 cites W2744741566 @default.
• W4206720207 doi "https://doi.org/10.1159/000522071" @default.
• W4206720207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35051929" @default.
• W4206720207 hasPublicationYear "2022" @default.
• W4206720207 type Work @default.
• W4206720207 citedByCount "4" @default.
• W4206720207 countsByYear W42067202072022 @default.
• W4206720207 countsByYear W42067202072023 @default.
• W4206720207 crossrefType "journal-article" @default.
• W4206720207 hasAuthorship W4206720207A5013245218 @default.
• W4206720207 hasAuthorship W4206720207A5037218495 @default.
• W4206720207 hasAuthorship W4206720207A5076304295 @default.
• W4206720207 hasAuthorship W4206720207A5083301096 @default.
• W4206720207 hasConcept C126322002 @default.
• W4206720207 hasConcept C134018914 @default.
• W4206720207 hasConcept C153852466 @default.
• W4206720207 hasConcept C185592680 @default.
• W4206720207 hasConcept C22814914 @default.
• W4206720207 hasConcept C2777417653 @default.
• W4206720207 hasConcept C2778248108 @default.
• W4206720207 hasConcept C2778319317 @default.
• W4206720207 hasConcept C71924100 @default.
• W4206720207 hasConcept C89560881 @default.
• W4206720207 hasConceptScore W4206720207C126322002 @default.
• W4206720207 hasConceptScore W4206720207C134018914 @default.
• W4206720207 hasConceptScore W4206720207C153852466 @default.
• W4206720207 hasConceptScore W4206720207C185592680 @default.
• W4206720207 hasConceptScore W4206720207C22814914 @default.
• W4206720207 hasConceptScore W4206720207C2777417653 @default.
• W4206720207 hasConceptScore W4206720207C2778248108 @default.
• W4206720207 hasConceptScore W4206720207C2778319317 @default.
• W4206720207 hasConceptScore W4206720207C71924100 @default.
• W4206720207 hasConceptScore W4206720207C89560881 @default.
• W4206720207 hasIssue "4" @default.
• W4206720207 hasLocation W42067202071 @default.
• W4206720207 hasLocation W42067202072 @default.
• W4206720207 hasOpenAccess W4206720207 @default.
• W4206720207 hasPrimaryLocation W42067202071 @default.
• W4206720207 hasRelatedWork W2086863876 @default.
• W4206720207 hasRelatedWork W2336600081 @default.
• W4206720207 hasRelatedWork W2403988761 @default.
• W4206720207 hasRelatedWork W2413111851 @default.
• W4206720207 hasRelatedWork W2414363365 @default.
• W4206720207 hasRelatedWork W2587863346 @default.
• W4206720207 hasRelatedWork W2769647791 @default.
• W4206720207 hasRelatedWork W3000145512 @default.
• W4206720207 hasRelatedWork W4248501375 @default.
• W4206720207 hasRelatedWork W4384038228 @default.
• W4206720207 hasVolume "145" @default.
• W4206720207 isParatext "false" @default.
• W4206720207 isRetracted "false" @default.
• W4206720207 workType "article" @default.