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- W4206739925 abstract "Abstract Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is a emerging tick-borne phlebovirus with a high fatality rate of 12–30%, which has an expanding endemic and causes thousands of infections every year. Central nervous system (CNS) manifestations are an important risk factor for the death outcome of SFTS. In-depth understanding of the process of SFTSV invading the brain is critical for developing effective anti-SFTS encephalitis therapeutics. Here, we reported the change of viral load of brain at different time points after intraperitoneal infection of SFTSV in newborn C57/BL6 mice. The virus invaded the brain at 3 hours post-infection (hpi). Notably, the viral load increased exponentially after 24 hpi. In addition, we reported that in addition to macrophages, SFTSV infected neurons and replicated in brain. These findings provide insights into the CNS manifestations of severe SFTS, which may aid in drug development and encephalitis therapeutics." @default.
- W4206739925 created "2022-01-26" @default.
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- W4206739925 date "2022-01-19" @default.
- W4206739925 modified "2023-10-18" @default.
- W4206739925 title "Severe Fever with Thrombocytopenia Syndrome Virus Replicates in the Brain Tissue and Damages Neuron in Newborn Mice" @default.
- W4206739925 doi "https://doi.org/10.21203/rs.3.rs-1143683/v1" @default.
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