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• W4206748317 abstract "Objective Environmental exposures exacerbate age-related pathologies, such as cardiovascular and neurodegenerative diseases. Nanoparticulates, and specifically carbon nanomaterials, are a fast-growing contributor to the category of inhalable pollutants, whose risks to health are only now being unraveled. The current study assessed the exacerbating effect of age on multiwalled-carbon nanotube (MWCNT) exposure in young and old C57BL/6 and ApoE−/− mice.Materials and methods Female C57BL/6 and apolipoprotein E-deficient (ApoE−/−) mice, aged 8 weeks and 15 months, were exposed to 0 or 40 µg MWCNT via oropharyngeal aspiration. Pulmonary inflammation, inflammatory bioactivity of serum, and neurometabolic changes were assessed at 24 h post-exposure.Results Pulmonary neutrophil infiltration was induced by MWCNT in bronchoalveolar lavage fluid in both C57BL/6 and ApoE−/−. Macrophage counts decreased with MWCNT exposure in ApoE−/− mice but were unaffected by exposure in C57BL/6 mice. Older mice appeared to have greater MWCNT-induced total protein in lavage fluid. BALF cytokines and chemokines were elevated with MWCNT exposure, but CCL2, CXCL1, and CXCL10 showed reduced responses to MWCNT in older mice. However, no significant serum inflammatory bioactivity was detected. Cerebellar metabolic changes in response to MWCNT were modest, but age and strain significantly influenced metabolite profiles assessed. ApoE−/− mice and older mice exhibited less robust metabolite changes in response to exposure, suggesting a reduced health reserve.Conclusions Age influences the pulmonary and neurological responses to short-term MWCNT exposure. However, with only the model of moderate aging (15 months) in this study, the responses appeared modest compared to inhaled toxicant impacts in more advanced aging models." @default.
• W4206748317 created "2022-01-26" @default.
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• W4206748317 date "2022-01-17" @default.
• W4206748317 modified "2023-09-26" @default.
• W4206748317 title "Aging influence on pulmonary and systemic inflammation and neural metabolomics arising from pulmonary multi-walled carbon nanotube exposure in apolipoprotein E-deficient and C57BL/6 female mice" @default.
• W4206748317 cites W158881778 @default.
• W4206748317 cites W1917062358 @default.
• W4206748317 cites W1981790552 @default.
• W4206748317 cites W1990922779 @default.
• W4206748317 cites W1992567223 @default.
• W4206748317 cites W2011707607 @default.
• W4206748317 cites W2013906646 @default.
• W4206748317 cites W2015368735 @default.
• W4206748317 cites W2019300253 @default.
• W4206748317 cites W2019723623 @default.
• W4206748317 cites W2027183666 @default.
• W4206748317 cites W2027914973 @default.
• W4206748317 cites W2035252462 @default.
• W4206748317 cites W2038286460 @default.
• W4206748317 cites W2041692988 @default.
• W4206748317 cites W2046315474 @default.
• W4206748317 cites W2055539199 @default.
• W4206748317 cites W2087243986 @default.
• W4206748317 cites W2089929841 @default.
• W4206748317 cites W2096337121 @default.
• W4206748317 cites W2096673955 @default.
• W4206748317 cites W2112299930 @default.
• W4206748317 cites W2117105773 @default.
• W4206748317 cites W2140718540 @default.
• W4206748317 cites W2147440511 @default.
• W4206748317 cites W2148099625 @default.
• W4206748317 cites W2150751323 @default.
• W4206748317 cites W2159904710 @default.
• W4206748317 cites W2162072506 @default.
• W4206748317 cites W2171741011 @default.
• W4206748317 cites W2186578978 @default.
• W4206748317 cites W2199322501 @default.
• W4206748317 cites W2257198177 @default.
• W4206748317 cites W2332143474 @default.
• W4206748317 cites W2337350925 @default.
• W4206748317 cites W2395253867 @default.
• W4206748317 cites W2404687407 @default.
• W4206748317 cites W2410374774 @default.
• W4206748317 cites W2520597008 @default.
• W4206748317 cites W2521336928 @default.
• W4206748317 cites W2522432693 @default.
• W4206748317 cites W2530753724 @default.
• W4206748317 cites W2549552700 @default.
• W4206748317 cites W2551087237 @default.
• W4206748317 cites W2558529070 @default.
• W4206748317 cites W2560748808 @default.
• W4206748317 cites W2591366418 @default.
• W4206748317 cites W2601738889 @default.
• W4206748317 cites W2768073701 @default.
• W4206748317 cites W2777892103 @default.
• W4206748317 cites W2790281733 @default.
• W4206748317 cites W2793585092 @default.
• W4206748317 cites W2807531409 @default.
• W4206748317 cites W2890035992 @default.
• W4206748317 cites W2899598349 @default.
• W4206748317 cites W2900242715 @default.
• W4206748317 cites W2905149850 @default.
• W4206748317 cites W2911147760 @default.
• W4206748317 cites W2914025980 @default.
• W4206748317 cites W2941994989 @default.
• W4206748317 cites W2947567577 @default.
• W4206748317 cites W2948276343 @default.
• W4206748317 cites W2956040167 @default.
• W4206748317 cites W2970433500 @default.
• W4206748317 cites W2976451393 @default.
• W4206748317 cites W2986638019 @default.
• W4206748317 cites W3013207020 @default.
• W4206748317 cites W3025445735 @default.
• W4206748317 cites W3111509171 @default.
• W4206748317 cites W3111928832 @default.
• W4206748317 cites W3154352730 @default.
• W4206748317 cites W3202783556 @default.
• W4206748317 cites W3206687244 @default.
• W4206748317 cites W4313359608 @default.
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• W4206748317 doi "https://doi.org/10.1080/08958378.2022.2026538" @default.
• W4206748317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35037817" @default.
• W4206748317 hasPublicationYear "2022" @default.
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