FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206749373> ?p ?o ?g. }

• W4206749373 abstract "The impact of viral infections on the central nervous system is widely known. Virus-related neuropsychiatric and neurobehavioral syndromes are caused by the distortion of cognitive, affective, behavioral, and perceptual domains. Although it is a commonly known phenomenon, the mechanism behind it is not well-understood. The contagious and deadly features of coronavirus disease 2019 (COVID-19) have been associated with the virus-host cell interaction at the molecular level. However, there is no reliable biomarker characterizing the disease progression. Studies of the structure, function, and evolution of coronavirus transmembrane spike glycoproteins (S-, N-, and E-proteins) suggest an essential role of protein chirality in virus-cell membrane interaction. The virus-host interaction is the subject of multidisciplinary research from the biochirality and systems biology, to cell physiology and non-equilibrium thermodynamics of phase transitions in proteins. At the protein level, virus-host interaction is modulated by the amino acid sequence of viral proteins and cellular metabolism. Enzymatic and spontaneous post-translational modifications (PTMs) are two mutually influential mechanisms governing the dynamics of virus and host cell proteome. Among them, phosphorylation and racemization are the most inter-related and studied. The spontaneous phase transitions within viral glycoprotein impacts the cell-entry capability of the virus. The spontaneous racemization is a particular and highly specific metabolic event in virus-cell interaction that is the focus of our attention. Many viral proteins are characterized by a high proportion of the serine (Ser) residues, which are the common target of the host-cell glycosylation, phosphorylation, and racemization, and proteolytic enzymes. Particularly, coronavirus N proteins were found to be phosphorylated at multiple Ser residues, a portion of which are shown to be phosphorylation-prone by the Ser-associated kinases. Since Ser is known as one of the most racemization prone amino acids, we promote an idea of the specific impact of spontaneous racemization at Ser residues on virus-host interaction." @default.
• W4206749373 created "2022-01-25" @default.
• W4206749373 date "2020-08-04" @default.
• W4206749373 modified "2023-09-27" @default.
• W4206749373 title "Racemization Hypothesis of COVID-19. Tip of the Iceberg" @default.
• W4206749373 cites W131370642 @default.
• W4206749373 cites W1559960346 @default.
• W4206749373 cites W1952812303 @default.
• W4206749373 cites W1973582688 @default.
• W4206749373 cites W1978492897 @default.
• W4206749373 cites W1979254755 @default.
• W4206749373 cites W2000548405 @default.
• W4206749373 cites W2006544087 @default.
• W4206749373 cites W2011634611 @default.
• W4206749373 cites W2019824896 @default.
• W4206749373 cites W2029458983 @default.
• W4206749373 cites W2031595188 @default.
• W4206749373 cites W2034419049 @default.
• W4206749373 cites W2037877475 @default.
• W4206749373 cites W2053188339 @default.
• W4206749373 cites W2059753456 @default.
• W4206749373 cites W2062641936 @default.
• W4206749373 cites W2068107112 @default.
• W4206749373 cites W2073771726 @default.
• W4206749373 cites W2089367187 @default.
• W4206749373 cites W2091368178 @default.
• W4206749373 cites W2096194507 @default.
• W4206749373 cites W2100707762 @default.
• W4206749373 cites W2101414552 @default.
• W4206749373 cites W2106157017 @default.
• W4206749373 cites W2106447813 @default.
• W4206749373 cites W2107786601 @default.
• W4206749373 cites W2109496267 @default.
• W4206749373 cites W2122797682 @default.
• W4206749373 cites W2140674451 @default.
• W4206749373 cites W2143421246 @default.
• W4206749373 cites W2160720092 @default.
• W4206749373 cites W2165810907 @default.
• W4206749373 cites W2289132128 @default.
• W4206749373 cites W2292742428 @default.
• W4206749373 cites W2470646526 @default.
• W4206749373 cites W2513547424 @default.
• W4206749373 cites W2554465683 @default.
• W4206749373 cites W2577466502 @default.
• W4206749373 cites W2600432485 @default.
• W4206749373 cites W2619904095 @default.
• W4206749373 cites W2767878402 @default.
• W4206749373 cites W2770670302 @default.
• W4206749373 cites W2776184602 @default.
• W4206749373 cites W2795488917 @default.
• W4206749373 cites W2801068193 @default.
• W4206749373 cites W2803748520 @default.
• W4206749373 cites W2807278927 @default.
• W4206749373 cites W2810413485 @default.
• W4206749373 cites W2891317436 @default.
• W4206749373 cites W2892265819 @default.
• W4206749373 cites W2904632490 @default.
• W4206749373 cites W2905355305 @default.
• W4206749373 cites W2924486308 @default.
• W4206749373 cites W2924785418 @default.
• W4206749373 cites W2961230248 @default.
• W4206749373 cites W2966543706 @default.
• W4206749373 cites W2973051052 @default.
• W4206749373 cites W2973125047 @default.
• W4206749373 cites W2994076975 @default.
• W4206749373 cites W3008011904 @default.
• W4206749373 cites W3008148491 @default.
• W4206749373 cites W3009335299 @default.
• W4206749373 cites W3011176674 @default.
• W4206749373 cites W3012696170 @default.
• W4206749373 cites W3014361958 @default.
• W4206749373 cites W3014416593 @default.
• W4206749373 cites W3015477849 @default.
• W4206749373 cites W3015536776 @default.
• W4206749373 cites W3023103130 @default.
• W4206749373 cites W3025162994 @default.
• W4206749373 cites W3026032531 @default.
• W4206749373 cites W4240855048 @default.
• W4206749373 doi "https://doi.org/10.47485/2693-2490.1033" @default.
• W4206749373 hasPublicationYear "2020" @default.
• W4206749373 type Work @default.
• W4206749373 citedByCount "1" @default.
• W4206749373 countsByYear W42067493732021 @default.
• W4206749373 crossrefType "journal-article" @default.
• W4206749373 hasConcept C104317684 @default.
• W4206749373 hasConcept C104397665 @default.
• W4206749373 hasConcept C108625454 @default.
• W4206749373 hasConcept C140704245 @default.
• W4206749373 hasConcept C141231307 @default.
• W4206749373 hasConcept C142724271 @default.
• W4206749373 hasConcept C159047783 @default.
• W4206749373 hasConcept C2522874641 @default.
• W4206749373 hasConcept C2777119779 @default.
• W4206749373 hasConcept C2777648638 @default.
• W4206749373 hasConcept C2779134260 @default.
• W4206749373 hasConcept C2780879997 @default.
• W4206749373 hasConcept C3008058167 @default.
• W4206749373 hasConcept C524204448 @default.
• W4206749373 hasConcept C54355233 @default.
• W4206749373 hasConcept C55493867 @default.

• next