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- W4206754235 abstract "Pancreatic ductal adenocarcinoma (PDAC), as one of the most malignant tumors with dense desmoplastic stroma, forms a specific matrix barrier to hinder effective diagnosis and therapy. To date, a paramount challenge is in the search for intelligent nanotheranostics for such hypopermeable tumors, especially in breaking the PDAC-specific physical barrier. The unpredictable in vivo behaviors of nanotheranostics, that is, real-time tracking where, when, and how they cross the physical barriers and are taken up by tumor cells, are the major bottleneck. Herein, we elaborately design sequence-activated nanotheranostic TCM-U11&Cy@P with dual-channel near-infrared fluorescence outputs for monitoring in vivo behaviors in a sequential fashion. This nanotheranostic with a programmable targeting capability effectively breaks through the PDAC barriers. Ultimately, the released aggregation-induced emission (AIE) particle TCM-U11 directly interacts with PDAC cells and penetrates into the deep tissue. Impressively, this fluorescent nanotheranostic intraoperatively can map human clinical PDAC specimens with high resolution. We believe that this unique sequence-activated fluorescent strategy expands the repertoire of nanotheranostics in the treatment of hypopermeable tumors." @default.
- W4206754235 created "2022-01-26" @default.
- W4206754235 creator A5004486459 @default.
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- W4206754235 date "2022-01-10" @default.
- W4206754235 modified "2023-09-25" @default.
- W4206754235 title "Sequence-Activated Fluorescent Nanotheranostics for Real-Time Profiling Pancreatic Cancer" @default.
- W4206754235 cites W2083710155 @default.
- W4206754235 cites W2097609323 @default.
- W4206754235 cites W2149597677 @default.
- W4206754235 cites W2474094449 @default.
- W4206754235 cites W2560717561 @default.
- W4206754235 cites W2579046240 @default.
- W4206754235 cites W2590680367 @default.
- W4206754235 cites W2603197431 @default.
- W4206754235 cites W2618728835 @default.
- W4206754235 cites W2746094882 @default.
- W4206754235 cites W2746888048 @default.
- W4206754235 cites W2774731752 @default.
- W4206754235 cites W2780626714 @default.
- W4206754235 cites W2793080730 @default.
- W4206754235 cites W2802852094 @default.
- W4206754235 cites W2809444920 @default.
- W4206754235 cites W2893402254 @default.
- W4206754235 cites W2899093059 @default.
- W4206754235 cites W2904984126 @default.
- W4206754235 cites W2915283599 @default.
- W4206754235 cites W2915910399 @default.
- W4206754235 cites W2915959393 @default.
- W4206754235 cites W2936366750 @default.
- W4206754235 cites W2942172826 @default.
- W4206754235 cites W2944103495 @default.
- W4206754235 cites W2948736254 @default.
- W4206754235 cites W2952132059 @default.
- W4206754235 cites W2954597343 @default.
- W4206754235 cites W2954994048 @default.
- W4206754235 cites W2969503538 @default.
- W4206754235 cites W2969760259 @default.
- W4206754235 cites W2973226654 @default.
- W4206754235 cites W2974996748 @default.
- W4206754235 cites W2982275548 @default.
- W4206754235 cites W2982593820 @default.
- W4206754235 cites W2987442686 @default.
- W4206754235 cites W2989686095 @default.
- W4206754235 cites W2989822266 @default.
- W4206754235 cites W2992915880 @default.
- W4206754235 cites W2995502256 @default.
- W4206754235 cites W2996809662 @default.
- W4206754235 cites W3001191913 @default.
- W4206754235 cites W3003391130 @default.
- W4206754235 cites W3004746393 @default.
- W4206754235 cites W3005714260 @default.
- W4206754235 cites W3007212572 @default.
- W4206754235 cites W3007814591 @default.
- W4206754235 cites W3008322531 @default.
- W4206754235 cites W3010003232 @default.
- W4206754235 cites W3010156166 @default.
- W4206754235 cites W3011351825 @default.
- W4206754235 cites W3012484408 @default.
- W4206754235 cites W3015714009 @default.
- W4206754235 cites W3016129808 @default.
- W4206754235 cites W3046200021 @default.
- W4206754235 cites W3071431406 @default.
- W4206754235 cites W3085558408 @default.
- W4206754235 cites W3086680449 @default.
- W4206754235 cites W3097851618 @default.
- W4206754235 cites W3103948518 @default.
- W4206754235 cites W3111029008 @default.
- W4206754235 cites W3112454234 @default.
- W4206754235 cites W3112558747 @default.
- W4206754235 cites W3116916480 @default.
- W4206754235 cites W3118793459 @default.
- W4206754235 cites W3119005666 @default.
- W4206754235 cites W3120571033 @default.
- W4206754235 cites W3122043967 @default.
- W4206754235 cites W3126839734 @default.
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- W4206754235 cites W3131638433 @default.
- W4206754235 cites W3136264734 @default.
- W4206754235 cites W3157539725 @default.
- W4206754235 cites W3159585736 @default.
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- W4206754235 cites W3162021374 @default.
- W4206754235 cites W3163185045 @default.
- W4206754235 cites W3180220806 @default.
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- W4206754235 doi "https://doi.org/10.1021/jacsau.1c00553" @default.
- W4206754235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35098241" @default.
- W4206754235 hasPublicationYear "2022" @default.
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