Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206768223> ?p ?o ?g. }
- W4206768223 endingPage "553" @default.
- W4206768223 startingPage "544" @default.
- W4206768223 abstract "Melatonin is a biogenic amine that can be found in plants, animals and microorganism. The metabolic pathway of melatonin is different in various organisms, and biosynthetic endogenous melatonin acts as a molecular signal and antioxidant protection against external stress. Microbial synthesis pathways of melatonin are similar to those of animals but different from those of plants. At present, the method of using microorganism fermentation to produce melatonin is gradually prevailing, and exploring the biosynthetic pathway of melatonin to modify microorganism is becoming the mainstream, which has more advantages than traditional chemical synthesis. Here, we review recent advances in the synthesis, optimization of melatonin pathway. l-tryptophan is one of the two crucial precursors for the synthesis of melatonin, which can be produced through a four-step reaction. Enzymes involved in melatonin synthesis have low specificity and catalytic efficiency. Site-directed mutation, directed evolution or promotion of cofactor synthesis can enhance enzyme activity and increase the metabolic flow to promote microbial melatonin production. On the whole, the status and bottleneck of melatonin biosynthesis can be improved to a higher level, providing an effective reference for future microbial modification." @default.
- W4206768223 created "2022-01-25" @default.
- W4206768223 creator A5012518350 @default.
- W4206768223 creator A5013749731 @default.
- W4206768223 creator A5019781637 @default.
- W4206768223 creator A5038313069 @default.
- W4206768223 creator A5039766784 @default.
- W4206768223 creator A5050158840 @default.
- W4206768223 creator A5056870367 @default.
- W4206768223 date "2022-03-01" @default.
- W4206768223 modified "2023-10-01" @default.
- W4206768223 title "Melatonin biosynthesis pathways in nature and its production in engineered microorganisms" @default.
- W4206768223 cites W1519699837 @default.
- W4206768223 cites W1546489326 @default.
- W4206768223 cites W1551735280 @default.
- W4206768223 cites W1571821264 @default.
- W4206768223 cites W1590249399 @default.
- W4206768223 cites W1636032674 @default.
- W4206768223 cites W1890047923 @default.
- W4206768223 cites W1963718311 @default.
- W4206768223 cites W1965476257 @default.
- W4206768223 cites W1979205517 @default.
- W4206768223 cites W1981283917 @default.
- W4206768223 cites W1983308408 @default.
- W4206768223 cites W1984876692 @default.
- W4206768223 cites W1988107743 @default.
- W4206768223 cites W1990948097 @default.
- W4206768223 cites W1992003514 @default.
- W4206768223 cites W1994448136 @default.
- W4206768223 cites W2000608537 @default.
- W4206768223 cites W2005509300 @default.
- W4206768223 cites W2012006993 @default.
- W4206768223 cites W2015380839 @default.
- W4206768223 cites W2026186053 @default.
- W4206768223 cites W2027372708 @default.
- W4206768223 cites W2030666458 @default.
- W4206768223 cites W2031167586 @default.
- W4206768223 cites W2036323991 @default.
- W4206768223 cites W2037830660 @default.
- W4206768223 cites W2041762487 @default.
- W4206768223 cites W2044498079 @default.
- W4206768223 cites W2047230223 @default.
- W4206768223 cites W2049485995 @default.
- W4206768223 cites W2053474812 @default.
- W4206768223 cites W2058413317 @default.
- W4206768223 cites W2059992609 @default.
- W4206768223 cites W2061855305 @default.
- W4206768223 cites W2062876845 @default.
- W4206768223 cites W2064182599 @default.
- W4206768223 cites W2067659919 @default.
- W4206768223 cites W2071074533 @default.
- W4206768223 cites W2077726906 @default.
- W4206768223 cites W2080082459 @default.
- W4206768223 cites W2086423987 @default.
- W4206768223 cites W2086872004 @default.
- W4206768223 cites W2087368063 @default.
- W4206768223 cites W2088218955 @default.
- W4206768223 cites W2089870031 @default.
- W4206768223 cites W2091879423 @default.
- W4206768223 cites W2095690986 @default.
- W4206768223 cites W2108257991 @default.
- W4206768223 cites W2111159272 @default.
- W4206768223 cites W2113872813 @default.
- W4206768223 cites W2118307844 @default.
- W4206768223 cites W2121767327 @default.
- W4206768223 cites W2124160075 @default.
- W4206768223 cites W2129097863 @default.
- W4206768223 cites W2135271644 @default.
- W4206768223 cites W2141072066 @default.
- W4206768223 cites W2141531075 @default.
- W4206768223 cites W2144168448 @default.
- W4206768223 cites W2151413459 @default.
- W4206768223 cites W2152875113 @default.
- W4206768223 cites W2157429392 @default.
- W4206768223 cites W2161084332 @default.
- W4206768223 cites W2162871918 @default.
- W4206768223 cites W2185845448 @default.
- W4206768223 cites W2198442234 @default.
- W4206768223 cites W2202603680 @default.
- W4206768223 cites W2211110732 @default.
- W4206768223 cites W2265497150 @default.
- W4206768223 cites W2285534366 @default.
- W4206768223 cites W2311345574 @default.
- W4206768223 cites W2343904218 @default.
- W4206768223 cites W2484682923 @default.
- W4206768223 cites W2508187204 @default.
- W4206768223 cites W2516348400 @default.
- W4206768223 cites W2518394958 @default.
- W4206768223 cites W2568280231 @default.
- W4206768223 cites W2746723602 @default.
- W4206768223 cites W2772977605 @default.
- W4206768223 cites W2792159457 @default.
- W4206768223 cites W2802103023 @default.
- W4206768223 cites W2802572380 @default.
- W4206768223 cites W2805102708 @default.
- W4206768223 cites W2892017366 @default.
- W4206768223 cites W2896673296 @default.
- W4206768223 cites W2905175892 @default.