Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206784385> ?p ?o ?g. }
- W4206784385 endingPage "938" @default.
- W4206784385 startingPage "921" @default.
- W4206784385 abstract "A potential load-bearing bone substitution and repair material, that is, carbon fiber (CF)-reinforced magnesium-doped hydroxyapatite (CF/Mg-HAs) composites with excellent mechanical performance and tailored biological properties, was constructed via the hydrothermal method and spark plasma sintering. A high-resolution transmission electron microscopy (TEM) was employed to characterize the nanostructure of magnesium-doped hydroxyapatite (Mg-HA). TEM images showed that the doping of Mg-induced distortions and dislocations in the hydroxyapatite lattice, resulting in decreased crystallinity and enhanced dissolution. Compressive strengths of 10% magnesium-doped hydroxyapatite (1Mg-HAs) and CF-reinforced 1Mg-HAs (CF/1Mg-HAs) were within the range of that of cortical bone. Compared with 1Mg-HAs, the fracture toughness of CF/1Mg-HAs increased by approximately 38%. The bioactivity, biocompatibility, and osteogenic induction properties of Mg-HAs and CF/Mg-HAs composites were evaluated in vitro using simulated body fluid (SBF) immersion, cell culture, osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and expression of genes associated with osteogenesis. When Mg-HAs were immersed in SBF, Mg2+ continued to release for up to 21 days. Mg-HAs demonstrated a satisfactory ability to induce apatite formation in comparison with HAs. The cell proliferation and morphology on CF/1Mg-HAs were similar to those of 1Mg-HAs, suggesting that adding CF had no adverse effect on cellular activity. The expression levels of osteogenesis-related genes [osteocalcin (OPN), osteopontin (OCN), and runt-related transcription factor 2 (Runx2)] on 1Mg-HAs were significantly higher at days 3 and 7 than those on HAs and 0.5Mg-HAs groups. This finding suggests that a certain amount of Mg doping had beneficial influences in the different stages of osteogenic differentiation and could induce osteogenic differentiation of BMSCs. The new bone volume to total volume ratio of implanted 1Mg-HAs (30.9% ± 4.1%) and CF/1Mg-HAs (25.4% ± 5.4%) was remarkably higher than that of HAs (21.6% ± 3.9%). 1Mg-HAs and CF/1Mg-HAs tailored an ideal effect of new bone information and implant osseointegration. The excellent mechanical performance and tailored biological properties of CF/Mg-HAs were attributed to nano Mg-doped HA, CF reinforcing, refined microstructure, and controlled composition." @default.
- W4206784385 created "2022-01-26" @default.
- W4206784385 creator A5003436014 @default.
- W4206784385 creator A5018557213 @default.
- W4206784385 creator A5018849776 @default.
- W4206784385 creator A5019206637 @default.
- W4206784385 creator A5020181096 @default.
- W4206784385 creator A5039887299 @default.
- W4206784385 creator A5051125527 @default.
- W4206784385 creator A5073565357 @default.
- W4206784385 date "2022-01-14" @default.
- W4206784385 modified "2023-10-09" @default.
- W4206784385 title "Potential Load-Bearing Bone Substitution Material: Carbon-Fiber-Reinforced Magnesium-Doped Hydroxyapatite Composites with Excellent Mechanical Performance and Tailored Biological Properties" @default.
- W4206784385 cites W1975682654 @default.
- W4206784385 cites W1991267506 @default.
- W4206784385 cites W1999521415 @default.
- W4206784385 cites W2010973203 @default.
- W4206784385 cites W2014792900 @default.
- W4206784385 cites W2022789289 @default.
- W4206784385 cites W2023318061 @default.
- W4206784385 cites W2024425879 @default.
- W4206784385 cites W2027077673 @default.
- W4206784385 cites W2030960880 @default.
- W4206784385 cites W2064417438 @default.
- W4206784385 cites W2071790855 @default.
- W4206784385 cites W2073003105 @default.
- W4206784385 cites W2128779995 @default.
- W4206784385 cites W2153588940 @default.
- W4206784385 cites W2160319765 @default.
- W4206784385 cites W2295126609 @default.
- W4206784385 cites W2414468034 @default.
- W4206784385 cites W2484056679 @default.
- W4206784385 cites W2510068900 @default.
- W4206784385 cites W2527839792 @default.
- W4206784385 cites W2581019733 @default.
- W4206784385 cites W2601115712 @default.
- W4206784385 cites W2605580878 @default.
- W4206784385 cites W2617470414 @default.
- W4206784385 cites W2741340736 @default.
- W4206784385 cites W2758225068 @default.
- W4206784385 cites W2765842953 @default.
- W4206784385 cites W2766485483 @default.
- W4206784385 cites W2770974893 @default.
- W4206784385 cites W2789500273 @default.
- W4206784385 cites W2792344735 @default.
- W4206784385 cites W2794357667 @default.
- W4206784385 cites W2801057601 @default.
- W4206784385 cites W2809960619 @default.
- W4206784385 cites W2886967724 @default.
- W4206784385 cites W2887227477 @default.
- W4206784385 cites W2889114464 @default.
- W4206784385 cites W2896918073 @default.
- W4206784385 cites W2898350923 @default.
- W4206784385 cites W2905688515 @default.
- W4206784385 cites W2910047871 @default.
- W4206784385 cites W2912076075 @default.
- W4206784385 cites W2914658741 @default.
- W4206784385 cites W2942288638 @default.
- W4206784385 cites W2948040484 @default.
- W4206784385 cites W2956291078 @default.
- W4206784385 cites W2976523983 @default.
- W4206784385 cites W2982189302 @default.
- W4206784385 cites W2986288500 @default.
- W4206784385 cites W2993240816 @default.
- W4206784385 cites W2995108211 @default.
- W4206784385 cites W2997497626 @default.
- W4206784385 cites W3010181862 @default.
- W4206784385 cites W3010738056 @default.
- W4206784385 cites W3011468229 @default.
- W4206784385 cites W3048925464 @default.
- W4206784385 cites W3091822204 @default.
- W4206784385 cites W3094090170 @default.
- W4206784385 cites W3107036058 @default.
- W4206784385 cites W3123978889 @default.
- W4206784385 cites W3129186212 @default.
- W4206784385 cites W3129578525 @default.
- W4206784385 cites W3140559517 @default.
- W4206784385 cites W3142050701 @default.
- W4206784385 cites W3155621507 @default.
- W4206784385 cites W3160141400 @default.
- W4206784385 cites W3160929390 @default.
- W4206784385 cites W3170534184 @default.
- W4206784385 cites W3182809791 @default.
- W4206784385 cites W3185357097 @default.
- W4206784385 doi "https://doi.org/10.1021/acsbiomaterials.1c01247" @default.
- W4206784385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35029364" @default.
- W4206784385 hasPublicationYear "2022" @default.
- W4206784385 type Work @default.
- W4206784385 citedByCount "3" @default.
- W4206784385 countsByYear W42067843852023 @default.
- W4206784385 crossrefType "journal-article" @default.
- W4206784385 hasAuthorship W4206784385A5003436014 @default.
- W4206784385 hasAuthorship W4206784385A5018557213 @default.
- W4206784385 hasAuthorship W4206784385A5018849776 @default.
- W4206784385 hasAuthorship W4206784385A5019206637 @default.
- W4206784385 hasAuthorship W4206784385A5020181096 @default.
- W4206784385 hasAuthorship W4206784385A5039887299 @default.
- W4206784385 hasAuthorship W4206784385A5051125527 @default.