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- W4206787439 endingPage "1070" @default.
- W4206787439 startingPage "1070" @default.
- W4206787439 abstract "Chronic liver diseases are commonly associated with dysregulated cholesterol metabolism. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease of the proprotein convertase family that is mainly synthetized and secreted by the liver, and represents one of the key regulators of circulating low-density lipoprotein (LDL) cholesterol levels. Its ability to bind and induce LDL-receptor degradation, in particular in the liver, increases circulating LDL-cholesterol levels in the blood. Hence, inhibition of PCSK9 has become a very potent tool for the treatment of hypercholesterolemia. Besides PCSK9 limiting entry of LDL-derived cholesterol, affecting multiple cholesterol-related functions in cells, more recent studies have associated PCSK9 with various other cellular processes, including inflammation, fatty acid metabolism, cancerogenesis and visceral adiposity. It is increasingly becoming evident that additional roles for PCSK9 beyond cholesterol homeostasis are crucial for liver physiology in health and disease, often contributing to pathophysiology. This review will summarize studies analyzing circulating and hepatic PCSK9 levels in patients with chronic liver diseases. The factors affecting PCSK9 levels in the circulation and in hepatocytes, clinically relevant studies and the pathophysiological role of PCSK9 in chronic liver injury are discussed." @default.
- W4206787439 created "2022-01-25" @default.
- W4206787439 creator A5071105199 @default.
- W4206787439 creator A5075612423 @default.
- W4206787439 date "2022-01-19" @default.
- W4206787439 modified "2023-09-26" @default.
- W4206787439 title "Emerging Insights on the Diverse Roles of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Chronic Liver Diseases: Cholesterol Metabolism and Beyond" @default.
- W4206787439 cites W1135824353 @default.
- W4206787439 cites W1252855759 @default.
- W4206787439 cites W1492672801 @default.
- W4206787439 cites W1504064570 @default.
- W4206787439 cites W1575192516 @default.
- W4206787439 cites W1864167487 @default.
- W4206787439 cites W189389301 @default.
- W4206787439 cites W1923289550 @default.
- W4206787439 cites W1965712234 @default.
- W4206787439 cites W1966941449 @default.
- W4206787439 cites W1968112386 @default.
- W4206787439 cites W1972660602 @default.
- W4206787439 cites W1977773843 @default.
- W4206787439 cites W1980248069 @default.
- W4206787439 cites W1984150991 @default.
- W4206787439 cites W1986040042 @default.
- W4206787439 cites W1986425794 @default.
- W4206787439 cites W1990237691 @default.
- W4206787439 cites W1998390386 @default.
- W4206787439 cites W2000307707 @default.
- W4206787439 cites W2004032902 @default.
- W4206787439 cites W2004409501 @default.
- W4206787439 cites W2005922901 @default.
- W4206787439 cites W2009995339 @default.
- W4206787439 cites W2013175577 @default.
- W4206787439 cites W2013982259 @default.
- W4206787439 cites W2016981683 @default.
- W4206787439 cites W2019703802 @default.
- W4206787439 cites W2020034972 @default.
- W4206787439 cites W2022870329 @default.
- W4206787439 cites W2023220752 @default.
- W4206787439 cites W2024110748 @default.
- W4206787439 cites W2024624676 @default.
- W4206787439 cites W2025383646 @default.
- W4206787439 cites W2025946759 @default.
- W4206787439 cites W2026136832 @default.
- W4206787439 cites W2035099895 @default.
- W4206787439 cites W2040612932 @default.
- W4206787439 cites W2045315353 @default.
- W4206787439 cites W2050348933 @default.
- W4206787439 cites W2055571770 @default.
- W4206787439 cites W2056376819 @default.
- W4206787439 cites W2057430111 @default.
- W4206787439 cites W2057968913 @default.
- W4206787439 cites W2064994526 @default.
- W4206787439 cites W2066450795 @default.
- W4206787439 cites W2067539811 @default.
- W4206787439 cites W2069386166 @default.
- W4206787439 cites W2073438109 @default.
- W4206787439 cites W2073931194 @default.
- W4206787439 cites W2084310268 @default.
- W4206787439 cites W2091876682 @default.
- W4206787439 cites W2094108957 @default.
- W4206787439 cites W2099136586 @default.
- W4206787439 cites W2108493094 @default.
- W4206787439 cites W2110124859 @default.
- W4206787439 cites W2118152092 @default.
- W4206787439 cites W2118242699 @default.
- W4206787439 cites W2120991468 @default.
- W4206787439 cites W2122864632 @default.
- W4206787439 cites W2123332331 @default.
- W4206787439 cites W2135530906 @default.
- W4206787439 cites W2136379071 @default.
- W4206787439 cites W2138915349 @default.
- W4206787439 cites W2146010644 @default.
- W4206787439 cites W2152660499 @default.
- W4206787439 cites W2153495280 @default.
- W4206787439 cites W2155292327 @default.
- W4206787439 cites W2157559566 @default.
- W4206787439 cites W2160945270 @default.
- W4206787439 cites W216121951 @default.
- W4206787439 cites W2163424622 @default.
- W4206787439 cites W2205982384 @default.
- W4206787439 cites W2212216121 @default.
- W4206787439 cites W2215742785 @default.
- W4206787439 cites W2238462784 @default.
- W4206787439 cites W2253819322 @default.
- W4206787439 cites W2288393367 @default.
- W4206787439 cites W2326705748 @default.
- W4206787439 cites W2342909101 @default.
- W4206787439 cites W2343113982 @default.
- W4206787439 cites W2384749578 @default.
- W4206787439 cites W2406712574 @default.
- W4206787439 cites W2415824834 @default.
- W4206787439 cites W2465805460 @default.
- W4206787439 cites W2521631210 @default.
- W4206787439 cites W2522376836 @default.
- W4206787439 cites W2523595269 @default.
- W4206787439 cites W2524545167 @default.
- W4206787439 cites W2528112543 @default.
- W4206787439 cites W2558593518 @default.