FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206788900> ?p ?o ?g. }

• W4206788900 endingPage "303" @default.
• W4206788900 startingPage "294" @default.
• W4206788900 abstract "Sca-1 is a surface marker for murine hematopoietic stem cells (HSCs) and type-I interferon is a key regulator for Lin-Sca-1+ HSCs expansion through Ifnar/Stat-1/Sca-1-signaling. In this study we aimed to characterize the role and regulation of Sca-1+ cells in pancreatic regeneration.To characterize Sca-1 in vivo, immunohistochemistry and immunofluorescence staining of Sca-1 was conducted in normal pancreas, in cerulein-mediated acute pancreatitis, and in Kras-triggered cancerous lesions. Ifnar/Stat-1/Sca-1-signaling was studied in type-I IFN-treated epithelial explants of adult wildtype, Ifnar-/-, and Stat-1-/- mice. Sca-1 induction was analyzed by gene expression and FACS analysis. After isolation of pancreatic epithelial Lin-Sca-1+cells, pancreatosphere-formation and immunofluorescence-assays were carried out to investigate self-renewal and differentiation capabilities.Sca-1+ cells were located in periacinar and periductal spaces and showed an enrichment during cerulein-induced acute pancreatitis (23.2/100 μm2 ± 4.9 SEM) and in early inflammation-mediated carcinogenic lesions of the pancreas of KrasG12D mice (35.8/100 μm2 ± SEM 1.9) compared to controls (3.6/100 μm2 ± 1.3 SEM). Pancreatic Lin-Sca-1+ cells displayed a small population of 1.46% ± 0.12 SEM in FACS. In IFN-β treated pancreatic epithelial explants, Sca-1 expression was increased, and Lin-Sca-1+ cells were enriched in vitro (from 1.49% ± 0.36 SEM to 3.85% ± 0.78 SEM). Lin-Sca-1+ cells showed a 12 to 51-fold higher capacity for clonal self-renewal compared to Lin-Sca-1- cells and generated cells express markers of the acinar and ductal compartment.Pancreatic Sca-1+ cells enriched during parenchymal damage showed a significant capacity for cell renewal and in vitro plasticity, suggesting that corresponding to the type I interferon-dependent regulation of Lin-Sca-1+ hematopoietic stem cells, pancreatic Sca-1+ cells also employ type-I-interferon for regulating progenitor-cell-homeostasis." @default.
• W4206788900 created "2022-01-26" @default.
• W4206788900 creator A5007111032 @default.
• W4206788900 creator A5025400329 @default.
• W4206788900 creator A5027928946 @default.
• W4206788900 creator A5038947617 @default.
• W4206788900 creator A5045571547 @default.
• W4206788900 creator A5047932326 @default.
• W4206788900 creator A5049580011 @default.
• W4206788900 creator A5050743910 @default.
• W4206788900 creator A5055451744 @default.
• W4206788900 creator A5064386033 @default.
• W4206788900 creator A5071097794 @default.
• W4206788900 creator A5075899127 @default.
• W4206788900 creator A5081600574 @default.
• W4206788900 creator A5089550509 @default.
• W4206788900 date "2022-03-01" @default.
• W4206788900 modified "2023-10-18" @default.
• W4206788900 title "Sca-1 is a marker for cell plasticity in murine pancreatic epithelial cells and induced by IFN-β in vitro" @default.
• W4206788900 cites W1721336579 @default.
• W4206788900 cites W1830287761 @default.
• W4206788900 cites W1967081779 @default.
• W4206788900 cites W1969831578 @default.
• W4206788900 cites W1970291390 @default.
• W4206788900 cites W1982781304 @default.
• W4206788900 cites W1987220381 @default.
• W4206788900 cites W1993913862 @default.
• W4206788900 cites W2011059916 @default.
• W4206788900 cites W2012511191 @default.
• W4206788900 cites W2024174149 @default.
• W4206788900 cites W2024725637 @default.
• W4206788900 cites W2026748421 @default.
• W4206788900 cites W2027550738 @default.
• W4206788900 cites W2041739600 @default.
• W4206788900 cites W2052721366 @default.
• W4206788900 cites W2052904272 @default.
• W4206788900 cites W205639457 @default.
• W4206788900 cites W2056646351 @default.
• W4206788900 cites W2058214634 @default.
• W4206788900 cites W2066135299 @default.
• W4206788900 cites W2075810641 @default.
• W4206788900 cites W2080338079 @default.
• W4206788900 cites W2087276195 @default.
• W4206788900 cites W2088693506 @default.
• W4206788900 cites W2094836768 @default.
• W4206788900 cites W2105597640 @default.
• W4206788900 cites W2108244474 @default.
• W4206788900 cites W2110447217 @default.
• W4206788900 cites W2119578188 @default.
• W4206788900 cites W2129781547 @default.
• W4206788900 cites W2130112621 @default.
• W4206788900 cites W2137987484 @default.
• W4206788900 cites W2147063599 @default.
• W4206788900 cites W2148078342 @default.
• W4206788900 cites W2163360413 @default.
• W4206788900 cites W2168420558 @default.
• W4206788900 cites W2417644647 @default.
• W4206788900 cites W2522304627 @default.
• W4206788900 cites W2556759986 @default.
• W4206788900 cites W2613671225 @default.
• W4206788900 cites W2978148866 @default.
• W4206788900 doi "https://doi.org/10.1016/j.pan.2022.01.006" @default.
• W4206788900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35120820" @default.
• W4206788900 hasPublicationYear "2022" @default.
• W4206788900 type Work @default.
• W4206788900 citedByCount "3" @default.
• W4206788900 countsByYear W42067889002022 @default.
• W4206788900 countsByYear W42067889002023 @default.
• W4206788900 crossrefType "journal-article" @default.
• W4206788900 hasAuthorship W4206788900A5007111032 @default.
• W4206788900 hasAuthorship W4206788900A5025400329 @default.
• W4206788900 hasAuthorship W4206788900A5027928946 @default.
• W4206788900 hasAuthorship W4206788900A5038947617 @default.
• W4206788900 hasAuthorship W4206788900A5045571547 @default.
• W4206788900 hasAuthorship W4206788900A5047932326 @default.
• W4206788900 hasAuthorship W4206788900A5049580011 @default.
• W4206788900 hasAuthorship W4206788900A5050743910 @default.
• W4206788900 hasAuthorship W4206788900A5055451744 @default.
• W4206788900 hasAuthorship W4206788900A5064386033 @default.
• W4206788900 hasAuthorship W4206788900A5071097794 @default.
• W4206788900 hasAuthorship W4206788900A5075899127 @default.
• W4206788900 hasAuthorship W4206788900A5081600574 @default.
• W4206788900 hasAuthorship W4206788900A5089550509 @default.
• W4206788900 hasBestOaLocation W42067889001 @default.
• W4206788900 hasConcept C126322002 @default.
• W4206788900 hasConcept C134018914 @default.
• W4206788900 hasConcept C142724271 @default.
• W4206788900 hasConcept C153911025 @default.
• W4206788900 hasConcept C159654299 @default.
• W4206788900 hasConcept C203014093 @default.
• W4206788900 hasConcept C2775967933 @default.
• W4206788900 hasConcept C2778236600 @default.
• W4206788900 hasConcept C2778764654 @default.
• W4206788900 hasConcept C28328180 @default.
• W4206788900 hasConcept C502942594 @default.
• W4206788900 hasConcept C71924100 @default.
• W4206788900 hasConcept C86803240 @default.
• W4206788900 hasConcept C95444343 @default.

• next