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• W4206792541 endingPage "102713" @default.
• W4206792541 startingPage "102713" @default.
• W4206792541 abstract "To evaluate the effectiveness of Photodynamic Therapy (PDT) in the treatment of Oral Potentially Malignant Disorders (OPMDs) patients.An electronic search was conducted to retrieve articles published until September 2021. Meta-analyses were conducted for the outcomes of complete response (CR) and any response (AR) after treatment with PDT using data from single-arm studies, case series and non-randomised controlled trials (NRCTs).In total, 49 articles were included. RCTs revealed insignificant mean difference (MD) in efficacy index between PDT and comparison groups (MD: 1.32; 95% CI:-28.10-30.72, p=0.930). The likelihood of CR (OR:0.84; 95% CI: 0.42-1.71, p=0.637) or AR (OR:2.10; 95% CI: 0.31-14.25, p=0.448) was not different in PDT group when compared with any comparison treatments in NRCTs. CR/AR among single arm studies was 60.6% (95% CI: 50.5-70.7, P<0.001) and 93.7% (95% CI:91.5-95.8, P<0.001) respectively. Higher prevalence of CR and AR was observed for dysplasia or carcinoma insitu (CIS) (CR: 81%, 95% CI: 70.8-91.3, P<0.001; AR: 94.3%; 95% CI: 89-99.6, P<0.001) and actinic cheilitis (AC) (CR: 73.9%, 95% CI: 65.9-81.9, P<0.001; AR:97%; 95% CI:94.9-99, P<0.001).More than half of the patients receiving PDT showed CR, with more than 90% responding to the treatment. PDT was most effective on oral dysplasias, followed by AC." @default.
• W4206792541 created "2022-01-25" @default.
• W4206792541 creator A5017758102 @default.
• W4206792541 creator A5043235078 @default.
• W4206792541 creator A5079520782 @default.
• W4206792541 creator A5086089209 @default.
• W4206792541 date "2022-03-01" @default.
• W4206792541 modified "2023-10-16" @default.
• W4206792541 title "Photodynamic therapy for oral potentially malignant disorders: A systematic review and meta-analysis" @default.
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• W4206792541 doi "https://doi.org/10.1016/j.pdpdt.2022.102713" @default.
• W4206792541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34999271" @default.
• W4206792541 hasPublicationYear "2022" @default.
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