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- W4206814521 abstract "While guideline-based treatment recommendations for many cardiovascular diseases, including stable angina, acute coronary syndromes, and atrial fibrillation, are advanced in their evidence base, there remain many questions and evidence gaps for guiding treatment of patients with PAD. Indeed, much of the evidence for effective cardiovascular risk–reducing therapies for patients with PAD has been extrapolated from large cardiovascular trials. Patients with PAD are a medically complex group, often with multiple comorbidities, such as advanced renal disease, diabetes, and coronary artery disease. Although there is a need to increase the evidence base through clinical trials in this population, the implementation and design of trials in the PAD space are challenging due to several key aspects, including fragmentation of care for PAD patients, difficulties recruiting patients into PAD studies, geographic mismatch between PAD-prevalent areas and traditional research sites, lack of a strong advocacy network for patients with PAD, and complexities regarding optimal trial design to appropriately examine patient-reported and functional outcomes (Fig. 1)." @default.
- W4206814521 created "2022-01-25" @default.
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- W4206814521 date "2022-05-01" @default.
- W4206814521 modified "2023-09-26" @default.
- W4206814521 title "Challenges in Peripheral Artery Disease Clinical Trial Implementation and Design" @default.
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- W4206814521 doi "https://doi.org/10.1016/j.cjca.2021.12.021" @default.
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