FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206815078> ?p ?o ?g. }

• W4206815078 endingPage "660" @default.
• W4206815078 startingPage "649" @default.
• W4206815078 abstract "Clinical care is moving from a one size fits all approach to a setting in which treatment decisions are based on individual treatment response, needs, preferences, and risk. Research into personalized treatment strategies aims to discover currently unknown markers that identify individuals who would benefit from treatments that are nonoptimal at the population level. Before investing in research to identify these markers, it is important to assess whether such research has the potential to generate value. Thus, this article aims to develop a framework to prioritize research into the development of new personalized treatment strategies by creating a set of measures that assess the value of personalizing care based on a set of unknown patient characteristics.Generalizing ideas from the value of heterogeneity framework, we demonstrate 3 measures that assess the value of developing personalized treatment strategies. The first measure identifies the potential value of personalizing medicine within a given disease area. The next 2 measures highlight specific research priorities and subgroup structures that would lead to improved patient outcomes from the personalization of treatment decisions.We graphically present the 3 measures to perform sensitivity analyses around the key drivers of value, in particular, the correlation between the individual treatment benefits across the available treatment options. We illustrate these 3 measures using a previously published decision model and discuss how they can direct research in personalized medicine.We discuss 3 measures that form the basis of a novel framework to prioritize research into novel personalized treatment strategies. Our novel framework ensures that research targets personalized treatment strategies that have high potential to improve patient outcomes and health system efficiency.It is important to undertake research prioritization before conducting any research that aims to discover novel methods (e.g., biomarkers) for personalizing treatment.The value of unexplained heterogeneity can highlight disease areas in which personalizing treatment can be valuable and determine key priorities within that area.These priorities can be determined under assumptions of the magnitude of the individual-level treatment effect, which we explore in sensitivity analyses." @default.
• W4206815078 created "2022-01-25" @default.
• W4206815078 creator A5045881566 @default.
• W4206815078 creator A5083255844 @default.
• W4206815078 date "2022-01-13" @default.
• W4206815078 modified "2023-09-26" @default.
• W4206815078 title "Prioritizing Research in an Era of Personalized Medicine: The Potential Value of Unexplained Heterogeneity" @default.
• W4206815078 cites W1990694356 @default.
• W4206815078 cites W1994665973 @default.
• W4206815078 cites W2007706130 @default.
• W4206815078 cites W2019103356 @default.
• W4206815078 cites W2024158966 @default.
• W4206815078 cites W2046808071 @default.
• W4206815078 cites W2049976476 @default.
• W4206815078 cites W2069086045 @default.
• W4206815078 cites W2069629877 @default.
• W4206815078 cites W2080250864 @default.
• W4206815078 cites W2087137161 @default.
• W4206815078 cites W2094290836 @default.
• W4206815078 cites W2099220333 @default.
• W4206815078 cites W2105588106 @default.
• W4206815078 cites W2106065407 @default.
• W4206815078 cites W2131553265 @default.
• W4206815078 cites W2136624067 @default.
• W4206815078 cites W2140011409 @default.
• W4206815078 cites W2142816927 @default.
• W4206815078 cites W2145371590 @default.
• W4206815078 cites W2157477694 @default.
• W4206815078 cites W2158694566 @default.
• W4206815078 cites W2159953548 @default.
• W4206815078 cites W2169322031 @default.
• W4206815078 cites W2407805811 @default.
• W4206815078 cites W2737073005 @default.
• W4206815078 cites W2795262817 @default.
• W4206815078 cites W2798554280 @default.
• W4206815078 cites W2891927635 @default.
• W4206815078 cites W3122426397 @default.
• W4206815078 cites W3169630609 @default.
• W4206815078 doi "https://doi.org/10.1177/0272989x211072858" @default.
• W4206815078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35023403" @default.
• W4206815078 hasPublicationYear "2022" @default.
• W4206815078 type Work @default.
• W4206815078 citedByCount "2" @default.
• W4206815078 countsByYear W42068150782022 @default.
• W4206815078 countsByYear W42068150782023 @default.
• W4206815078 crossrefType "journal-article" @default.
• W4206815078 hasAuthorship W4206815078A5045881566 @default.
• W4206815078 hasAuthorship W4206815078A5083255844 @default.
• W4206815078 hasBestOaLocation W42068150781 @default.
• W4206815078 hasConcept C112930515 @default.
• W4206815078 hasConcept C119857082 @default.
• W4206815078 hasConcept C136764020 @default.
• W4206815078 hasConcept C142724271 @default.
• W4206815078 hasConcept C163763905 @default.
• W4206815078 hasConcept C177264268 @default.
• W4206815078 hasConcept C183003079 @default.
• W4206815078 hasConcept C199360897 @default.
• W4206815078 hasConcept C2522767166 @default.
• W4206815078 hasConcept C2776291640 @default.
• W4206815078 hasConcept C32220436 @default.
• W4206815078 hasConcept C41008148 @default.
• W4206815078 hasConcept C60644358 @default.
• W4206815078 hasConcept C71924100 @default.
• W4206815078 hasConcept C86803240 @default.
• W4206815078 hasConceptScore W4206815078C112930515 @default.
• W4206815078 hasConceptScore W4206815078C119857082 @default.
• W4206815078 hasConceptScore W4206815078C136764020 @default.
• W4206815078 hasConceptScore W4206815078C142724271 @default.
• W4206815078 hasConceptScore W4206815078C163763905 @default.
• W4206815078 hasConceptScore W4206815078C177264268 @default.
• W4206815078 hasConceptScore W4206815078C183003079 @default.
• W4206815078 hasConceptScore W4206815078C199360897 @default.
• W4206815078 hasConceptScore W4206815078C2522767166 @default.
• W4206815078 hasConceptScore W4206815078C2776291640 @default.
• W4206815078 hasConceptScore W4206815078C32220436 @default.
• W4206815078 hasConceptScore W4206815078C41008148 @default.
• W4206815078 hasConceptScore W4206815078C60644358 @default.
• W4206815078 hasConceptScore W4206815078C71924100 @default.
• W4206815078 hasConceptScore W4206815078C86803240 @default.
• W4206815078 hasFunder F4320320994 @default.
• W4206815078 hasFunder F4320334593 @default.
• W4206815078 hasFunder F4320338066 @default.
• W4206815078 hasIssue "5" @default.
• W4206815078 hasLocation W42068150781 @default.
• W4206815078 hasLocation W42068150782 @default.
• W4206815078 hasLocation W42068150783 @default.
• W4206815078 hasOpenAccess W4206815078 @default.
• W4206815078 hasPrimaryLocation W42068150781 @default.
• W4206815078 hasRelatedWork W2019254804 @default.
• W4206815078 hasRelatedWork W2047937781 @default.
• W4206815078 hasRelatedWork W2130911224 @default.
• W4206815078 hasRelatedWork W2323286088 @default.
• W4206815078 hasRelatedWork W2985494620 @default.
• W4206815078 hasRelatedWork W2998917833 @default.
• W4206815078 hasRelatedWork W3189111587 @default.
• W4206815078 hasRelatedWork W3208921508 @default.
• W4206815078 hasRelatedWork W4206815078 @default.
• W4206815078 hasRelatedWork W4386703825 @default.

• next