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• W4206818408 abstract "This chapter focuses on the physiological and compound-dependent factors affecting drug distribution into various tissues and discusses the in silico and in vitro data that can be integrated into a physiological distribution model to predict tissue distribution. The importance of estimating tissue concentrations at the site of pharmacological action and the application of physiologically based pharmacokinetic models to obtain time profiles of tissue concentrations is outlined. As with other pharmacokinetic properties, the rate and extent of tissue distribution of xenobiotics are influenced by both compound-specific and physiology-dependent factors. The extent of tissue distribution is determined by partition coefficients as well as binding to plasma and tissue proteins. In silico models for tissue partitioning can only handle partitioning driven by the physicochemical nature of the drug or the protein/lipid/water composition of the tissues. The concentrations of a drug at the target protein in a target tissue (site of action) drive its pharmacological response." @default.
• W4206818408 created "2022-01-26" @default.
• W4206818408 date "2021-08-18" @default.
• W4206818408 modified "2023-10-12" @default.
• W4206818408 title "PHYSIOLOGICAL MODEL FOR DISTRIBUTION" @default.
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• W4206818408 doi "https://doi.org/10.1002/9781119497813.ch5" @default.
• W4206818408 hasPublicationYear "2021" @default.
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