FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206900810> ?p ?o ?g. }

• W4206900810 abstract "This study aimed to investigate the effect of Yiqi Jiedu (YQJD) formula on the repair of corneal lesions in mice with recurrent herpes simplex virus keratitis (HSK). Sixty female BALB/c mice were randomly divided into three groups: a normal control group (Naive), a recurrence model group (Re), and a YQJD group. After inducing recurrence by ultraviolet irradiation, the ocular surfaces of different groups of mice were observed using a slit lamp and photographed, and ocular surface scores were calculated. The abundance of CD4+CD25+Foxp3+ regulatory T (Treg) cells was determined by flow cytometry in peripheral blood and spleen cells. The CD4+Foxp3+ Tregs were assessed by immunofluorescence in the cornea. The levels of the cytokines IL-10 and TGF-β in serum and splenocyte culture supernatants were detected by enzyme-linked immunosorbent assay. Furthermore, the activation status of the STAT5 signaling pathway was examined by protein blotting, and the effect of YQJD on Treg cells through inhibition of the STAT5 pathway was observed in vitro. YQJD alleviated corneal inflammation by enhancing the STAT5 signaling pathway, thereby promoting the differentiation of CD4+CD25+Foxp3+ Treg cells, increasing the levels of anti-inflammatory cytokines such as IL-10 and TGF-β, and maintaining immune tolerance. YQJD increased the proportion of CD4+Foxp3+ Treg cells; also, in the cornea, YQJD inhibited the aggregation of macrophages and CD4+ cells and reduced the proportion of Th17 cells and other pro-inflammatory cells. Moreover, YQJD promoted the secretion of IL-4 to protect the cornea, leading to the mitigation of corneal immunopathological damage. YQJD reduced corneal lesions in recurrent HSK mice by stimulating Treg cells, inducing immune tolerance, and inhibiting corneal immunopathological responses via modulation of the STAT5 signaling pathway." @default.
• W4206900810 created "2022-01-26" @default.
• W4206900810 creator A5021707892 @default.
• W4206900810 creator A5049692788 @default.
• W4206900810 creator A5053921240 @default.
• W4206900810 creator A5076614407 @default.
• W4206900810 creator A5076746128 @default.
• W4206900810 creator A5082844061 @default.
• W4206900810 date "2022-01-21" @default.
• W4206900810 modified "2023-10-14" @default.
• W4206900810 title "Activation of the STAT5 Signaling Pathway by Yiqi Jiedu Formula Induces Regulatory T Cell-Mediated Alleviation of Corneal Immunopathological Damage in Mice With Recurrent Herpes Simplex Keratitis" @default.
• W4206900810 cites W1550639122 @default.
• W4206900810 cites W1566416470 @default.
• W4206900810 cites W1568663209 @default.
• W4206900810 cites W1801506204 @default.
• W4206900810 cites W1928425848 @default.
• W4206900810 cites W2034109159 @default.
• W4206900810 cites W2050126319 @default.
• W4206900810 cites W2062520454 @default.
• W4206900810 cites W2075621822 @default.
• W4206900810 cites W2076194373 @default.
• W4206900810 cites W2084727005 @default.
• W4206900810 cites W2091785066 @default.
• W4206900810 cites W2098875512 @default.
• W4206900810 cites W2102762115 @default.
• W4206900810 cites W2121672225 @default.
• W4206900810 cites W2121977118 @default.
• W4206900810 cites W2153198333 @default.
• W4206900810 cites W2166238639 @default.
• W4206900810 cites W2168795040 @default.
• W4206900810 cites W2169230985 @default.
• W4206900810 cites W2183509798 @default.
• W4206900810 cites W2252727669 @default.
• W4206900810 cites W2345576086 @default.
• W4206900810 cites W2575603832 @default.
• W4206900810 cites W2616503392 @default.
• W4206900810 cites W2618977250 @default.
• W4206900810 cites W2621829867 @default.
• W4206900810 cites W2622415849 @default.
• W4206900810 cites W2624833312 @default.
• W4206900810 cites W2669262488 @default.
• W4206900810 cites W2735838422 @default.
• W4206900810 cites W2766484627 @default.
• W4206900810 cites W2775194855 @default.
• W4206900810 cites W2897491969 @default.
• W4206900810 cites W2897637939 @default.
• W4206900810 cites W2899207091 @default.
• W4206900810 cites W2900007365 @default.
• W4206900810 cites W2900733627 @default.
• W4206900810 cites W2902849407 @default.
• W4206900810 cites W2924346474 @default.
• W4206900810 cites W2937937386 @default.
• W4206900810 cites W2970148588 @default.
• W4206900810 cites W2981183570 @default.
• W4206900810 cites W2981951628 @default.
• W4206900810 cites W3009769989 @default.
• W4206900810 cites W3024471762 @default.
• W4206900810 cites W3092567816 @default.
• W4206900810 cites W3100319702 @default.
• W4206900810 cites W3103562211 @default.
• W4206900810 cites W4211052952 @default.
• W4206900810 doi "https://doi.org/10.3389/fphar.2021.790787" @default.
• W4206900810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35126129" @default.
• W4206900810 hasPublicationYear "2022" @default.
• W4206900810 type Work @default.
• W4206900810 citedByCount "0" @default.
• W4206900810 crossrefType "journal-article" @default.
• W4206900810 hasAuthorship W4206900810A5021707892 @default.
• W4206900810 hasAuthorship W4206900810A5049692788 @default.
• W4206900810 hasAuthorship W4206900810A5053921240 @default.
• W4206900810 hasAuthorship W4206900810A5076614407 @default.
• W4206900810 hasAuthorship W4206900810A5076746128 @default.
• W4206900810 hasAuthorship W4206900810A5082844061 @default.
• W4206900810 hasBestOaLocation W42069008101 @default.
• W4206900810 hasConcept C169760540 @default.
• W4206900810 hasConcept C187316574 @default.
• W4206900810 hasConcept C203014093 @default.
• W4206900810 hasConcept C2776090121 @default.
• W4206900810 hasConcept C2776882836 @default.
• W4206900810 hasConcept C2778296632 @default.
• W4206900810 hasConcept C2778560704 @default.
• W4206900810 hasConcept C2779727006 @default.
• W4206900810 hasConcept C54355233 @default.
• W4206900810 hasConcept C553184892 @default.
• W4206900810 hasConcept C71924100 @default.
• W4206900810 hasConcept C79484868 @default.
• W4206900810 hasConcept C86803240 @default.
• W4206900810 hasConcept C8891405 @default.
• W4206900810 hasConceptScore W4206900810C169760540 @default.
• W4206900810 hasConceptScore W4206900810C187316574 @default.
• W4206900810 hasConceptScore W4206900810C203014093 @default.
• W4206900810 hasConceptScore W4206900810C2776090121 @default.
• W4206900810 hasConceptScore W4206900810C2776882836 @default.
• W4206900810 hasConceptScore W4206900810C2778296632 @default.
• W4206900810 hasConceptScore W4206900810C2778560704 @default.
• W4206900810 hasConceptScore W4206900810C2779727006 @default.
• W4206900810 hasConceptScore W4206900810C54355233 @default.
• W4206900810 hasConceptScore W4206900810C553184892 @default.
• W4206900810 hasConceptScore W4206900810C71924100 @default.
• W4206900810 hasConceptScore W4206900810C79484868 @default.

• next