Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206907626> ?p ?o ?g. }
- W4206907626 endingPage "711" @default.
- W4206907626 startingPage "699" @default.
- W4206907626 abstract "Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes (T2D). Previous report showed that an immunomodulator FTY720, a sphingosine 1-phosphate (S1P) receptor modulator, sustainably normalized hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice. We further examined the effects of FTY720 on glucose homeostasis and diabetic complications in a translational nonhuman primate (NHP) model of spontaneously developed diabetes. The male diabetic cynomolgus macaques of 18-19 year old were randomly divided into Vehicle (Purified water, n = 5) and FTY720 (5 mg/kg, n = 7) groups with oral gavage once daily for 10 weeks followed by 10 weeks drug free period. Compared with the Vehicle group, FTY720 effectively lowered HbA1c, blood concentrations of fasting glucose (FBG) and insulin, hence, decreased homeostatic model assessment of insulin resistance (HOMA-IR); ameliorated glucose intolerance and restored glucose-stimulated insulin release, indicating rejuvenation of β-cell function in diabetic NHPs. Importantly, after withdrawal of FTY720, FBG, and HbA1c remained at low level in the drug free period. Echocardiography revealed that FTY720 significantly reduced proteinuria and improved cardiac left ventricular systolic function measured by increased ejection fraction and fractional shortening in the diabetic NHPs. Finally, flow cytometry analysis (FACS) detected that FTY720 significantly reduced CD4 + and CD8 + T lymphocytes as well as increased DC cells in the circulation. Immunomodulator FTY720 improves glucose homeostasis via rejuvenation of β-cell function, which can be mediated by suppression of cytotoxic CD8 + T lymphocytes to β-cells, thus, may be a novel immunotherapy to reverse T2D progression and ameliorate the diabetic complications." @default.
- W4206907626 created "2022-01-26" @default.
- W4206907626 creator A5001106926 @default.
- W4206907626 creator A5011597796 @default.
- W4206907626 creator A5033953722 @default.
- W4206907626 creator A5039982125 @default.
- W4206907626 creator A5041083185 @default.
- W4206907626 creator A5043058455 @default.
- W4206907626 creator A5056611512 @default.
- W4206907626 creator A5070369219 @default.
- W4206907626 creator A5076954185 @default.
- W4206907626 creator A5078620033 @default.
- W4206907626 creator A5087099599 @default.
- W4206907626 creator A5090930543 @default.
- W4206907626 date "2022-02-02" @default.
- W4206907626 modified "2023-09-27" @default.
- W4206907626 title "Immunomodulator FTY720 improves glucose homeostasis and diabetic complications by rejuvenation of <i>β</i> ‐cell function in nonhuman primate model of diabetes" @default.
- W4206907626 cites W1851228461 @default.
- W4206907626 cites W1929373940 @default.
- W4206907626 cites W1943096387 @default.
- W4206907626 cites W1962981647 @default.
- W4206907626 cites W1963542379 @default.
- W4206907626 cites W1972735773 @default.
- W4206907626 cites W1977672385 @default.
- W4206907626 cites W1981681666 @default.
- W4206907626 cites W1981864032 @default.
- W4206907626 cites W1987958157 @default.
- W4206907626 cites W1999963608 @default.
- W4206907626 cites W2003294373 @default.
- W4206907626 cites W2023029824 @default.
- W4206907626 cites W2024992738 @default.
- W4206907626 cites W2032919119 @default.
- W4206907626 cites W2034607874 @default.
- W4206907626 cites W2041739600 @default.
- W4206907626 cites W2059921365 @default.
- W4206907626 cites W2061172276 @default.
- W4206907626 cites W2064549454 @default.
- W4206907626 cites W2076458350 @default.
- W4206907626 cites W2078775078 @default.
- W4206907626 cites W2080812812 @default.
- W4206907626 cites W2081193499 @default.
- W4206907626 cites W2084574308 @default.
- W4206907626 cites W2088520118 @default.
- W4206907626 cites W2105629526 @default.
- W4206907626 cites W2113544353 @default.
- W4206907626 cites W2119256454 @default.
- W4206907626 cites W2121575990 @default.
- W4206907626 cites W2124131291 @default.
- W4206907626 cites W2126412386 @default.
- W4206907626 cites W2129754316 @default.
- W4206907626 cites W2132289617 @default.
- W4206907626 cites W2139851703 @default.
- W4206907626 cites W2154826894 @default.
- W4206907626 cites W2156278727 @default.
- W4206907626 cites W2160234571 @default.
- W4206907626 cites W2165349029 @default.
- W4206907626 cites W2165704853 @default.
- W4206907626 cites W2167876561 @default.
- W4206907626 cites W2607031541 @default.
- W4206907626 cites W2751155656 @default.
- W4206907626 cites W2897646808 @default.
- W4206907626 cites W2899748139 @default.
- W4206907626 cites W3003992222 @default.
- W4206907626 cites W3127149112 @default.
- W4206907626 cites W3216791550 @default.
- W4206907626 cites W4206907626 @default.
- W4206907626 doi "https://doi.org/10.1111/fcp.12760" @default.
- W4206907626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35064580" @default.
- W4206907626 hasPublicationYear "2022" @default.
- W4206907626 type Work @default.
- W4206907626 citedByCount "2" @default.
- W4206907626 countsByYear W42069076262022 @default.
- W4206907626 countsByYear W42069076262023 @default.
- W4206907626 crossrefType "journal-article" @default.
- W4206907626 hasAuthorship W4206907626A5001106926 @default.
- W4206907626 hasAuthorship W4206907626A5011597796 @default.
- W4206907626 hasAuthorship W4206907626A5033953722 @default.
- W4206907626 hasAuthorship W4206907626A5039982125 @default.
- W4206907626 hasAuthorship W4206907626A5041083185 @default.
- W4206907626 hasAuthorship W4206907626A5043058455 @default.
- W4206907626 hasAuthorship W4206907626A5056611512 @default.
- W4206907626 hasAuthorship W4206907626A5070369219 @default.
- W4206907626 hasAuthorship W4206907626A5076954185 @default.
- W4206907626 hasAuthorship W4206907626A5078620033 @default.
- W4206907626 hasAuthorship W4206907626A5087099599 @default.
- W4206907626 hasAuthorship W4206907626A5090930543 @default.
- W4206907626 hasBestOaLocation W42069076262 @default.
- W4206907626 hasConcept C126322002 @default.
- W4206907626 hasConcept C134018914 @default.
- W4206907626 hasConcept C2777180221 @default.
- W4206907626 hasConcept C2777391703 @default.
- W4206907626 hasConcept C2779306644 @default.
- W4206907626 hasConcept C3018667095 @default.
- W4206907626 hasConcept C555293320 @default.
- W4206907626 hasConcept C63645605 @default.
- W4206907626 hasConcept C71924100 @default.
- W4206907626 hasConceptScore W4206907626C126322002 @default.
- W4206907626 hasConceptScore W4206907626C134018914 @default.