Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206910546> ?p ?o ?g. }
- W4206910546 endingPage "218" @default.
- W4206910546 startingPage "201" @default.
- W4206910546 abstract "Stem and progenitor cells of the adult prostate epithelium have historically been believed to reside mainly or exclusively within the basal cell compartment and to possess basal-like phenotypic characteristics. Within the past decade, evidence of the existence of luminal epithelial cells exhibiting stem/progenitor properties has been obtained by lineage tracing and by functional characterization of sorted luminal-like cells. In 2020, the boom of single-cell transcriptomics led to increasingly exhaustive profiling of putative mouse luminal progenitor cells and, importantly, to the identification of cognate cells in the human prostate. The enrichment of luminal progenitor cells in genetically modified mouse models of prostate inflammation, benign prostate hypertrophy and prostate cancer, and the intrinsic castration tolerance of these cells, suggest their potential role in prostate pathogenesis and in resistance to androgen deprivation therapy. This Review bridges different approaches that have been used in the field to characterize luminal progenitor cells, including the unification of multiple identifiers employed to define these cells (names and markers). It also provides an overview of the intrinsic functional properties of luminal progenitor cells, and addresses their relevance in mouse and human prostate pathophysiology. In this Review, Baures et al. discuss prostate luminal progenitor cells, covering their functional properties and potential role in prostate pathology. In addition, the authors describe different approaches to classifying these cells, and unify multiple identifiers that have been used to define prostate luminal progenitor cells." @default.
- W4206910546 created "2022-01-26" @default.
- W4206910546 creator A5002845014 @default.
- W4206910546 creator A5028242882 @default.
- W4206910546 creator A5041012326 @default.
- W4206910546 creator A5058523274 @default.
- W4206910546 creator A5079923302 @default.
- W4206910546 creator A5081683246 @default.
- W4206910546 creator A5083030762 @default.
- W4206910546 creator A5086718204 @default.
- W4206910546 date "2022-01-25" @default.
- W4206910546 modified "2023-10-18" @default.
- W4206910546 title "Prostate luminal progenitor cells: from mouse to human, from health to disease" @default.
- W4206910546 cites W1557650544 @default.
- W4206910546 cites W1571877909 @default.
- W4206910546 cites W1770219813 @default.
- W4206910546 cites W1827628940 @default.
- W4206910546 cites W1966982923 @default.
- W4206910546 cites W1970242719 @default.
- W4206910546 cites W1972471919 @default.
- W4206910546 cites W1972677695 @default.
- W4206910546 cites W1978825747 @default.
- W4206910546 cites W1981802929 @default.
- W4206910546 cites W1995499417 @default.
- W4206910546 cites W1998546608 @default.
- W4206910546 cites W2001148099 @default.
- W4206910546 cites W2002228196 @default.
- W4206910546 cites W2003866931 @default.
- W4206910546 cites W2005274657 @default.
- W4206910546 cites W2007610579 @default.
- W4206910546 cites W2016844403 @default.
- W4206910546 cites W2029808948 @default.
- W4206910546 cites W2031263088 @default.
- W4206910546 cites W2032353251 @default.
- W4206910546 cites W2033230341 @default.
- W4206910546 cites W2037660742 @default.
- W4206910546 cites W2039015433 @default.
- W4206910546 cites W2046234516 @default.
- W4206910546 cites W2047918294 @default.
- W4206910546 cites W2049700579 @default.
- W4206910546 cites W2050235247 @default.
- W4206910546 cites W2058217018 @default.
- W4206910546 cites W2059586354 @default.
- W4206910546 cites W2064117760 @default.
- W4206910546 cites W2064589748 @default.
- W4206910546 cites W2064844805 @default.
- W4206910546 cites W2065503917 @default.
- W4206910546 cites W2066758604 @default.
- W4206910546 cites W2067061068 @default.
- W4206910546 cites W2067206898 @default.
- W4206910546 cites W2068881679 @default.
- W4206910546 cites W2069590452 @default.
- W4206910546 cites W2071003307 @default.
- W4206910546 cites W2080851462 @default.
- W4206910546 cites W2081597080 @default.
- W4206910546 cites W2087390112 @default.
- W4206910546 cites W2088371750 @default.
- W4206910546 cites W2091443952 @default.
- W4206910546 cites W2094098906 @default.
- W4206910546 cites W2097536603 @default.
- W4206910546 cites W2099054500 @default.
- W4206910546 cites W2100960809 @default.
- W4206910546 cites W2105504226 @default.
- W4206910546 cites W2107633226 @default.
- W4206910546 cites W2108075096 @default.
- W4206910546 cites W2118933841 @default.
- W4206910546 cites W2119336711 @default.
- W4206910546 cites W2121759271 @default.
- W4206910546 cites W2124330457 @default.
- W4206910546 cites W2129781547 @default.
- W4206910546 cites W2135190835 @default.
- W4206910546 cites W2137467802 @default.
- W4206910546 cites W2137782229 @default.
- W4206910546 cites W2141091746 @default.
- W4206910546 cites W2148416479 @default.
- W4206910546 cites W2148643283 @default.
- W4206910546 cites W2154430204 @default.
- W4206910546 cites W2156638837 @default.
- W4206910546 cites W2156923287 @default.
- W4206910546 cites W2160579552 @default.
- W4206910546 cites W2162002294 @default.
- W4206910546 cites W2163360413 @default.
- W4206910546 cites W2163373111 @default.
- W4206910546 cites W2165300664 @default.
- W4206910546 cites W2166686631 @default.
- W4206910546 cites W2167198420 @default.
- W4206910546 cites W2167608422 @default.
- W4206910546 cites W2168191492 @default.
- W4206910546 cites W2180142285 @default.
- W4206910546 cites W2288021051 @default.
- W4206910546 cites W2396961956 @default.
- W4206910546 cites W2418877057 @default.
- W4206910546 cites W2512594468 @default.
- W4206910546 cites W2524019073 @default.
- W4206910546 cites W2525383821 @default.
- W4206910546 cites W2529707188 @default.
- W4206910546 cites W2560495570 @default.
- W4206910546 cites W2567986926 @default.