FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206912658> ?p ?o ?g. }

• W4206912658 endingPage "327" @default.
• W4206912658 startingPage "318" @default.
• W4206912658 abstract "The abnormal differentiation of T helper 17 (Th17) cells is considered a vital promoter of immune thrombocytopenia (ITP) progression. Therefore, this study investigated the role of miR-199a-5p in Th17 differentiation and determined whether extracellular vesicles (EVs) derived from miR-199a-5p-modified adipose-derived mesenchymal stem cells (ADSCs) could relieve ITP by inhibiting Th17 differentiation. The miR-199a-5p level was lessened in the spleen tissues of mice with ITP, while the signal transducer and activator of transcription 3 (STAT3) expression and the population of Th17 in CD4+T cells were boosted. Functionally, miR-199a-5p overexpression lowered IL-17 secretion and the proportion of Th17/CD4+T cells. Further investigation showed that miR-199a-5p directly targeted STAT3 mRNA, and negatively modulated its expression. STAT3 overexpression was found to facilitate Th17 differentiation, which was subsequently abolished by miR-199a-5p overexpression. EVs isolated from miR-199a-5p-modified ADSCs (miR-199a-5p-EVs) highly expressed miR-199a-5p and could restrain CD4+T cells polarized toward a Th17 phenotype in vitro. Administering of miR-199a-5p-EVs elevated platelet counts and decreased the proportion of Th17/CD4+T cells in mice with ITP. Taken together, EVs derived from miR-199a-5p-modified ADSCs vividly repressed Th17 differentiation by transferring miR-199a-5p to CD4+T cells, thus ameliorating experimental ITP." @default.
• W4206912658 created "2022-01-26" @default.
• W4206912658 creator A5006639931 @default.
• W4206912658 creator A5008415072 @default.
• W4206912658 creator A5041995571 @default.
• W4206912658 creator A5059356708 @default.
• W4206912658 creator A5070166399 @default.
• W4206912658 creator A5074300225 @default.
• W4206912658 creator A5080653936 @default.
• W4206912658 date "2021-03-01" @default.
• W4206912658 modified "2023-10-14" @default.
• W4206912658 title "Extracellular vesicles derived from miR-199a-5p-modified adipose-derived mesenchymal stem cells alleviate immune thrombocytopenia by inhibiting T helper 17 differentiation" @default.
• W4206912658 cites W144423133 @default.
• W4206912658 cites W1515424972 @default.
• W4206912658 cites W1537063289 @default.
• W4206912658 cites W1965665614 @default.
• W4206912658 cites W1970574917 @default.
• W4206912658 cites W1988986333 @default.
• W4206912658 cites W1994521618 @default.
• W4206912658 cites W2018687481 @default.
• W4206912658 cites W2024490058 @default.
• W4206912658 cites W2058437162 @default.
• W4206912658 cites W2060523664 @default.
• W4206912658 cites W2070334783 @default.
• W4206912658 cites W2098701890 @default.
• W4206912658 cites W2101752862 @default.
• W4206912658 cites W2115788075 @default.
• W4206912658 cites W2173497140 @default.
• W4206912658 cites W2254667085 @default.
• W4206912658 cites W2334544135 @default.
• W4206912658 cites W2522607024 @default.
• W4206912658 cites W2604116492 @default.
• W4206912658 cites W2610072177 @default.
• W4206912658 cites W2780389061 @default.
• W4206912658 cites W2786389710 @default.
• W4206912658 cites W2791250268 @default.
• W4206912658 cites W2923243507 @default.
• W4206912658 cites W2950919606 @default.
• W4206912658 cites W2963997298 @default.
• W4206912658 cites W2987384074 @default.
• W4206912658 cites W2992347953 @default.
• W4206912658 cites W3001318867 @default.
• W4206912658 cites W3026403402 @default.
• W4206912658 cites W4211212002 @default.
• W4206912658 cites W612353151 @default.
• W4206912658 doi "https://doi.org/10.1038/s41374-020-00515-z" @default.
• W4206912658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33402685" @default.
• W4206912658 hasPublicationYear "2021" @default.
• W4206912658 type Work @default.
• W4206912658 citedByCount "8" @default.
• W4206912658 countsByYear W42069126582021 @default.
• W4206912658 countsByYear W42069126582022 @default.
• W4206912658 countsByYear W42069126582023 @default.
• W4206912658 crossrefType "journal-article" @default.
• W4206912658 hasAuthorship W4206912658A5006639931 @default.
• W4206912658 hasAuthorship W4206912658A5008415072 @default.
• W4206912658 hasAuthorship W4206912658A5041995571 @default.
• W4206912658 hasAuthorship W4206912658A5059356708 @default.
• W4206912658 hasAuthorship W4206912658A5070166399 @default.
• W4206912658 hasAuthorship W4206912658A5074300225 @default.
• W4206912658 hasAuthorship W4206912658A5080653936 @default.
• W4206912658 hasBestOaLocation W42069126581 @default.
• W4206912658 hasConcept C134018914 @default.
• W4206912658 hasConcept C153911025 @default.
• W4206912658 hasConcept C171089720 @default.
• W4206912658 hasConcept C171958077 @default.
• W4206912658 hasConcept C185592680 @default.
• W4206912658 hasConcept C198826908 @default.
• W4206912658 hasConcept C203014093 @default.
• W4206912658 hasConcept C2778923194 @default.
• W4206912658 hasConcept C502942594 @default.
• W4206912658 hasConcept C62478195 @default.
• W4206912658 hasConcept C86803240 @default.
• W4206912658 hasConcept C8891405 @default.
• W4206912658 hasConcept C95444343 @default.
• W4206912658 hasConceptScore W4206912658C134018914 @default.
• W4206912658 hasConceptScore W4206912658C153911025 @default.
• W4206912658 hasConceptScore W4206912658C171089720 @default.
• W4206912658 hasConceptScore W4206912658C171958077 @default.
• W4206912658 hasConceptScore W4206912658C185592680 @default.
• W4206912658 hasConceptScore W4206912658C198826908 @default.
• W4206912658 hasConceptScore W4206912658C203014093 @default.
• W4206912658 hasConceptScore W4206912658C2778923194 @default.
• W4206912658 hasConceptScore W4206912658C502942594 @default.
• W4206912658 hasConceptScore W4206912658C62478195 @default.
• W4206912658 hasConceptScore W4206912658C86803240 @default.
• W4206912658 hasConceptScore W4206912658C8891405 @default.
• W4206912658 hasConceptScore W4206912658C95444343 @default.
• W4206912658 hasIssue "3" @default.
• W4206912658 hasLocation W42069126581 @default.
• W4206912658 hasLocation W42069126582 @default.
• W4206912658 hasOpenAccess W4206912658 @default.
• W4206912658 hasPrimaryLocation W42069126581 @default.
• W4206912658 hasRelatedWork W2035129499 @default.
• W4206912658 hasRelatedWork W2120026864 @default.
• W4206912658 hasRelatedWork W2128795228 @default.
• W4206912658 hasRelatedWork W2154799225 @default.
• W4206912658 hasRelatedWork W2972231100 @default.

• next