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- W4206919783 abstract "Abstract Periodontitis is a chronic inflammatory disease characterized by periodontal tissue destruction and tooth loss. Clinically, the failure of periodontal therapy stems largely from an inability to control the inflammatory response. Resolution of inflammation is an active, energy-requiring repair process, not merely a passive termination of inflammation. AMP-activated protein kinase (AMPK), a key energy sensor, has been shown to negatively regulate inflammatory signaling pathways. ETC-1002 is an activator of AMPK. This study aimed to investigate the anti-inflammatory effects of ETC-1002 through modulating AMPK in periodontitis. Results suggested that ETC-1002 exerts anti-inflammatory effects in Pg-LPS-treated RAW264.7 cells via the AMPK/NF-κB pathway in vitro, and inhibits the progress of experimental periodontitis in mice in an AMPK signaling-dependent manner in vivo. These results provide evidence for the beneficial effects of ETC-1002 in the treatment of periodontitis." @default.
- W4206919783 created "2022-01-26" @default.
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- W4206919783 date "2022-01-21" @default.
- W4206919783 modified "2023-09-27" @default.
- W4206919783 title "ETC-1002 Attenuates Porphyromonas Gingivalis Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells via the AMPK/NF-κB Pathway and Exerts Ameliorative Effects in Experimental Periodontitis in Mice" @default.
- W4206919783 doi "https://doi.org/10.21203/rs.3.rs-1265993/v1" @default.
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