Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206923594> ?p ?o ?g. }
- W4206923594 endingPage "27" @default.
- W4206923594 startingPage "1" @default.
- W4206923594 abstract "This work aimed to evaluate the effect of carbonylation induced by tetracyclines, β-lactams, fluoroquinolones, and pyrethroids in caseins of bovine origin on their immunoreactivity and allergenicity. Using a spectrophotometric method, ELISA, dot-blot, and an IgE-mediated milk allergy mouse model, we confirmed that antibiotics and pesticides at their maximum residue limit, promoted the in vitro carbonylation of caseins (among 5.0 ± 0.01 and 67.5 ± 0.70 nmol of carbonyl/mg of protein); furthermore, carbonylations greater than 19 nmol significantly increase the in vitro IgE immunoreactivity of caseins (average OD among 0.63-1.50) regarding the negative control (average OD: 0.56). On the other hand, sensitized mice exposed to oxidized caseins showed increased clinical scores (2-5), positive skin tests, and footpad swelling (0.28-0.59 mm) compared to the negative control (1-2; negative skin tests; 0.1 mm, respectively), denoting increased allergenicity. These results suggest that casein carbonylation increases their IgE immunoreactivity and allergenicity, a fact that could be explained by the resistance to the digestion promoted by carbonylation and by conformational changes in the random coil casein structure, which can expose cryptic epitopes or neoepitopes." @default.
- W4206923594 created "2022-01-26" @default.
- W4206923594 creator A5008438524 @default.
- W4206923594 creator A5011582254 @default.
- W4206923594 creator A5015559773 @default.
- W4206923594 creator A5047512016 @default.
- W4206923594 creator A5050377577 @default.
- W4206923594 creator A5080260525 @default.
- W4206923594 creator A5089641575 @default.
- W4206923594 date "2022-01-24" @default.
- W4206923594 modified "2023-10-07" @default.
- W4206923594 title "Carbonylation induced by antibiotic and pesticide residues on casein increases its IgE binding and allergenicity" @default.
- W4206923594 cites W1807755555 @default.
- W4206923594 cites W1973262225 @default.
- W4206923594 cites W1980325199 @default.
- W4206923594 cites W1987053691 @default.
- W4206923594 cites W1993566791 @default.
- W4206923594 cites W2001948851 @default.
- W4206923594 cites W2027018033 @default.
- W4206923594 cites W2034192620 @default.
- W4206923594 cites W2048349805 @default.
- W4206923594 cites W2074036588 @default.
- W4206923594 cites W2075329646 @default.
- W4206923594 cites W2089383541 @default.
- W4206923594 cites W2129694722 @default.
- W4206923594 cites W2137895698 @default.
- W4206923594 cites W2158809385 @default.
- W4206923594 cites W2230973995 @default.
- W4206923594 cites W2268894947 @default.
- W4206923594 cites W2326466622 @default.
- W4206923594 cites W2344098795 @default.
- W4206923594 cites W2560343713 @default.
- W4206923594 cites W2565002200 @default.
- W4206923594 cites W2591417618 @default.
- W4206923594 cites W2651325810 @default.
- W4206923594 cites W2727962732 @default.
- W4206923594 cites W2734391407 @default.
- W4206923594 cites W2794891594 @default.
- W4206923594 cites W2799454352 @default.
- W4206923594 cites W2804446502 @default.
- W4206923594 cites W2883789863 @default.
- W4206923594 cites W2891581756 @default.
- W4206923594 cites W2913072547 @default.
- W4206923594 cites W2913649865 @default.
- W4206923594 cites W2934242914 @default.
- W4206923594 cites W2944559124 @default.
- W4206923594 cites W2960403291 @default.
- W4206923594 cites W2967849895 @default.
- W4206923594 cites W2968271970 @default.
- W4206923594 cites W2970864651 @default.
- W4206923594 cites W2971665246 @default.
- W4206923594 cites W2973459140 @default.
- W4206923594 cites W3000038593 @default.
- W4206923594 cites W3000734469 @default.
- W4206923594 cites W3006264952 @default.
- W4206923594 cites W3014700229 @default.
- W4206923594 cites W3018696485 @default.
- W4206923594 cites W3048748905 @default.
- W4206923594 cites W3100694827 @default.
- W4206923594 cites W3106884431 @default.
- W4206923594 cites W3204558303 @default.
- W4206923594 cites W3205128650 @default.
- W4206923594 doi "https://doi.org/10.1080/10715762.2022.2032020" @default.
- W4206923594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35068298" @default.
- W4206923594 hasPublicationYear "2022" @default.
- W4206923594 type Work @default.
- W4206923594 citedByCount "0" @default.
- W4206923594 crossrefType "journal-article" @default.
- W4206923594 hasAuthorship W4206923594A5008438524 @default.
- W4206923594 hasAuthorship W4206923594A5011582254 @default.
- W4206923594 hasAuthorship W4206923594A5015559773 @default.
- W4206923594 hasAuthorship W4206923594A5047512016 @default.
- W4206923594 hasAuthorship W4206923594A5050377577 @default.
- W4206923594 hasAuthorship W4206923594A5080260525 @default.
- W4206923594 hasAuthorship W4206923594A5089641575 @default.
- W4206923594 hasConcept C141105273 @default.
- W4206923594 hasConcept C159654299 @default.
- W4206923594 hasConcept C161790260 @default.
- W4206923594 hasConcept C168382676 @default.
- W4206923594 hasConcept C181199279 @default.
- W4206923594 hasConcept C185592680 @default.
- W4206923594 hasConcept C202751555 @default.
- W4206923594 hasConcept C203014093 @default.
- W4206923594 hasConcept C2776142715 @default.
- W4206923594 hasConcept C2781338088 @default.
- W4206923594 hasConcept C2911203004 @default.
- W4206923594 hasConcept C31903555 @default.
- W4206923594 hasConcept C512735826 @default.
- W4206923594 hasConcept C538909803 @default.
- W4206923594 hasConcept C55493867 @default.
- W4206923594 hasConcept C86803240 @default.
- W4206923594 hasConceptScore W4206923594C141105273 @default.
- W4206923594 hasConceptScore W4206923594C159654299 @default.
- W4206923594 hasConceptScore W4206923594C161790260 @default.
- W4206923594 hasConceptScore W4206923594C168382676 @default.
- W4206923594 hasConceptScore W4206923594C181199279 @default.
- W4206923594 hasConceptScore W4206923594C185592680 @default.
- W4206923594 hasConceptScore W4206923594C202751555 @default.