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• W4206930417 abstract "p53 plays a central role in tumor suppression. Emerging evidence suggests long noncoding RNA (lncRNA) as an important class of regulatory molecules that control the p53 signaling. Here, we report that the oncogenic lncRNA E2F1 messenger RNA (mRNA) stabilizing factor (EMS) and p53 mutually repress each other's expression. EMS is negatively regulated by p53. As a direct transcriptional repression target of p53, EMS is surprisingly shown to inhibit p53 expression. EMS associates with cytoplasmic polyadenylation element-binding protein 2 (CPEB2) and thus, disrupts the CPEB2-p53 mRNA interaction. This disassociation attenuates CPEB2-mediated p53 mRNA polyadenylation and suppresses p53 translation. Functionally, EMS is able to exert its oncogenic activities, at least partially, via the CPEB2-p53 axis. Together, these findings reveal a double-negative feedback loop between p53 and EMS, through which p53 is finely controlled. Our study also demonstrates a critical role for EMS in promoting tumorigenesis via the negative regulation of p53." @default.
• W4206930417 created "2022-01-26" @default.
• W4206930417 creator A5001589308 @default.
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• W4206930417 date "2022-01-12" @default.
• W4206930417 modified "2023-10-18" @default.
• W4206930417 title "Reciprocal modulation of long noncoding RNA EMS and p53 regulates tumorigenesis" @default.
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• W4206930417 doi "https://doi.org/10.1073/pnas.2111409119" @default.
• W4206930417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35022235" @default.
• W4206930417 hasPublicationYear "2022" @default.
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