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• W4206931194 abstract "HomeCirculation: Cardiovascular ImagingVol. 14, No. 3In This Issue of the Journal Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyRedditDiggEmail Jump toFree AccessEditorialPDF/EPUBIn This Issue of the Journal Robert J. GroplerMD Robert J. GroplerRobert J. Gropler https://orcid.org/0000-0002-6550-0570 Search for more papers by this author Originally published16 Mar 2021https://doi.org/10.1161/CIRCIMAGING.121.012625Circulation: Cardiovascular Imaging. 2021;14:e012625On behalf of the editorial team, I want to welcome you to the March 2021 issue of Circulation: Cardiovascular Imaging. Our selected topics discuss how both preclinical and human imaging is used to unravel mechanistic insights into cardiovascular physiology and disease, new imaging approaches to potentially better risk stratify patients and the promise of radiomics to enhance disease detection.Although left ventricular (LV) dysfunction in Ebstein’s anomaly is well known, the extent to which this is related to increased myocardial fibrosis (as is seen LV dysfunction from numerous other etiologies) is unknown. In an early proof-of-concept study, Aly and colleagues show children and adolescents with Ebstein’s anomaly exhibit cardiac magnetic resonance imaging (CMR) measured LV diffuse myocardial fibrosis that is associated with decreased LV strain and exercise tolerance and may be related to tissue hypoxia. Continuing medical education credit is offered for this article. In their editorial, Steimetz and Schuster nicely contextualize the study results with current knowledge, emphasize the early stage of the study, and encourage further research to study the link between myocardial fibrosis and LV function in these patients.Adenosine stress T1 mapping is an emerging CMR method to investigate coronary vascular function and myocardial ischemia without the need for an intravenous contrast agent. However, the mechanistic underpinnings of adenosine T1 reactivity, particularly in relation to changes in myocardial blood flow, are poorly understood. To help in this regard, Shah et al performed preclinical CMR in a variety of genetically modified mice under different forms of vasodilator stress and observed distinctly different mechanisms for T1 reactivity and myocardial blood flow changes. In their commentary, Schindler and Bhandiwad concisely summarize the vascular reactivity of different components of the coronary vasculature in response to different stimuli and how the results of the current study will add to our ability to better interrogate them in vivo.Right ventricular function is a well-established biomarker of cardiovascular health in patients with right-sided cardiac or pulmonary vascular disease. However, its role in predicting major adverse cardiovascular events beyond these conditions is less clear. Pumah and colleagues report right ventricular fraction measured by CMR is a powerful and independent predictor of major adverse cardiac events with broad generalizability across patients with known or suspected cardiovascular disease. The findings suggest a role for bi-ventricular disease phenotyping to enhance risk assessment in the broader cardiovascular disease populationDespite optimal medical therapy, up to 30% to 50% of patients with deep venous thrombosis will develop post-thrombotic syndrome; chronic venous insufficiency due to adverse remodeling of the venous system. Heightened inflammation has been implicated in the pathogenesis of post-thrombotic syndrome and thus, may serve as a target for imaging to follow syndrome progression and response to therapy. Kessinger et al demonstrate in a preclinical model of deep venous thrombosis serial 18F-fluorodeoxyglucose positron emission tomography/computed tomography (CT) predicts the magnitude of key pathological drivers of post-thrombotic syndrome and tracks therapeutic responses.The level of LV dysfunction following ST-segment–elevation myocardial infarction is a powerful prognostic indicator. However, LV ejection fraction and more recently global longitudinal strain do not account for the impact of loading conditions and thus, only provide a partial picture of overall LV systolic function. Global LV myocardial work efficiency which is derived from the integration of measurements of LV volume by 2-dimensional speckle tracking echocardiography and blood pressure measurements provides a more complete representation of global LV performance. Lustosa and colleagues, report in that following a ST-segment–elevation myocardial infarction, reduced global LV myocardial work efficiency is independently associated with all-cause mortality.Radiomics quantifies disease-specific textural features from biomedical images that are undetectable by the human eye. This textural information can be added to visually detected image features to enhance disease diagnosis. In Advances in Cardiovascular Imaging, Peng et al provide an in-depth discussion on the technical aspects of radiomics and its potential application in use of cardiac CT.In the Images in Cardiovascular Medicine section, Dagan and colleagues present an interesting case of cobalt cardiomyopathy mimicking cardiac amyloidosis on CMR. Yang et al provide an example of where CT aided in the management of a patient with an aorto-esophageal fistula and thoracic aorta pseudoaneurysm due to ingestion of a fishbone. Blissett and Foster describe how 2-dimensional echocardiography and CMR imaging aided in the long-term surveillance of a patient who underwent a rare repair for D-transposition of the great arteries. Antunez et al, present a case illustrating the value of 2-dimensional echocardiography and CT angiography to diagnose simultaneous aortic and pulmonary artery dissection in a patient with a patent ductus arteriosus. Paul and Mathew describe how 2-dimensional echocardiography and CMR aided in the diagnosis of post-traumatic LV dissection. Lee and colleagues describe the use of 2-dimensional echocardiography and cardiac CT in the diagnosis of pseudoaneurysm of LV outflow track late-onset as the cause of a patient’s chest pain.I thank you for reading Circulation: Cardiovascular Imaging and hope you enjoyed reading the various pieces and look forward to your future visits to the journal.Disclosures None.FootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association. Previous Back to top Next FiguresReferencesRelatedDetails March 2021Vol 14, Issue 3Article InformationMetrics Download: 8 © 2021 American Heart Association, Inc.https://doi.org/10.1161/CIRCIMAGING.121.012625PMID: 33722062 Originally publishedMarch 16, 2021 PDF download" @default.
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