FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206937488> ?p ?o ?g. }

• W4206937488 endingPage "265" @default.
• W4206937488 startingPage "256" @default.
• W4206937488 abstract "The hepatitis B virus (HBV) is a global public health challenge due to its highly contagious nature. It is estimated that almost 300 million people live with chronic HBV infection annually. Although nucleoside analogs markedly reduce the risk of liver disease progression, the analogs do not fully eradicate the virus. As such, new treatment options and drugs are urgently needed. Psoralen is a nourishing monomer of Chinese herb and is known to inhibit virus replication and inactivate viruses. In this study, we evaluated the potential of psoralen as an anti-HBV agent. Quantitative PCR and Southern blot analysis revealed that psoralen inhibited HBV replication in HepG2.2.15 ​cells in a concentration-dependent manner. Moreover, psoralen was also active against the 3TC/ETV-dual-resistant HBV mutant. Further investigations revealed that psoralen suppressed both HBV RNA transcription and core protein expression. The transcription factor FOXO1, a known target for PGC1α co-activation, binds to HBV pre-core/core promoter enhancer II region and activates HBV RNA transcription. Co-immunoprecipitation showed that psoralen suppressed the expression of FOXO1, thereby decreasing the binding of FOXO1 co-activator PGC1α to the HBV promoter. Overall, our results demonstrate that psoralen suppresses HBV RNA transcription by down-regulating the expression of FOXO1 resulting in a reduction of HBV replication." @default.
• W4206937488 created "2022-01-26" @default.
• W4206937488 creator A5001462210 @default.
• W4206937488 creator A5026278368 @default.
• W4206937488 creator A5038588425 @default.
• W4206937488 creator A5044300409 @default.
• W4206937488 creator A5047578093 @default.
• W4206937488 creator A5054980488 @default.
• W4206937488 creator A5079713143 @default.
• W4206937488 creator A5081850178 @default.
• W4206937488 creator A5091877690 @default.
• W4206937488 date "2022-04-01" @default.
• W4206937488 modified "2023-10-13" @default.
• W4206937488 title "Psoralen inhibits hepatitis B viral replication by down-regulating the host transcriptional machinery of viral promoters" @default.
• W4206937488 cites W1934998482 @default.
• W4206937488 cites W1980542173 @default.
• W4206937488 cites W1993631529 @default.
• W4206937488 cites W1998132528 @default.
• W4206937488 cites W2004439582 @default.
• W4206937488 cites W2010185867 @default.
• W4206937488 cites W2016433140 @default.
• W4206937488 cites W2021417532 @default.
• W4206937488 cites W2021838987 @default.
• W4206937488 cites W2030410762 @default.
• W4206937488 cites W2080876747 @default.
• W4206937488 cites W2111625427 @default.
• W4206937488 cites W2137174689 @default.
• W4206937488 cites W2137936579 @default.
• W4206937488 cites W2149475828 @default.
• W4206937488 cites W2163293418 @default.
• W4206937488 cites W2171444483 @default.
• W4206937488 cites W2186323593 @default.
• W4206937488 cites W2511252329 @default.
• W4206937488 cites W2532286598 @default.
• W4206937488 cites W2604240537 @default.
• W4206937488 cites W2619937760 @default.
• W4206937488 cites W2743892921 @default.
• W4206937488 cites W2768795275 @default.
• W4206937488 cites W2905611090 @default.
• W4206937488 cites W2915988733 @default.
• W4206937488 cites W2946409994 @default.
• W4206937488 cites W2982897022 @default.
• W4206937488 cites W2990660417 @default.
• W4206937488 cites W3004347501 @default.
• W4206937488 cites W3014175310 @default.
• W4206937488 cites W3023589539 @default.
• W4206937488 cites W3083174060 @default.
• W4206937488 cites W3094241158 @default.
• W4206937488 cites W3095226549 @default.
• W4206937488 cites W3097146219 @default.
• W4206937488 cites W3114043010 @default.
• W4206937488 doi "https://doi.org/10.1016/j.virs.2022.01.027" @default.
• W4206937488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35305922" @default.
• W4206937488 hasPublicationYear "2022" @default.
• W4206937488 type Work @default.
• W4206937488 citedByCount "4" @default.
• W4206937488 countsByYear W42069374882023 @default.
• W4206937488 crossrefType "journal-article" @default.
• W4206937488 hasAuthorship W4206937488A5001462210 @default.
• W4206937488 hasAuthorship W4206937488A5026278368 @default.
• W4206937488 hasAuthorship W4206937488A5038588425 @default.
• W4206937488 hasAuthorship W4206937488A5044300409 @default.
• W4206937488 hasAuthorship W4206937488A5047578093 @default.
• W4206937488 hasAuthorship W4206937488A5054980488 @default.
• W4206937488 hasAuthorship W4206937488A5079713143 @default.
• W4206937488 hasAuthorship W4206937488A5081850178 @default.
• W4206937488 hasAuthorship W4206937488A5091877690 @default.
• W4206937488 hasBestOaLocation W42069374881 @default.
• W4206937488 hasConcept C101762097 @default.
• W4206937488 hasConcept C104317684 @default.
• W4206937488 hasConcept C111936080 @default.
• W4206937488 hasConcept C138885662 @default.
• W4206937488 hasConcept C140704245 @default.
• W4206937488 hasConcept C150194340 @default.
• W4206937488 hasConcept C153911025 @default.
• W4206937488 hasConcept C159047783 @default.
• W4206937488 hasConcept C179926584 @default.
• W4206937488 hasConcept C194575299 @default.
• W4206937488 hasConcept C2522874641 @default.
• W4206937488 hasConcept C2780593183 @default.
• W4206937488 hasConcept C2781110370 @default.
• W4206937488 hasConcept C41895202 @default.
• W4206937488 hasConcept C552990157 @default.
• W4206937488 hasConcept C55493867 @default.
• W4206937488 hasConcept C73616013 @default.
• W4206937488 hasConcept C86339819 @default.
• W4206937488 hasConcept C86803240 @default.
• W4206937488 hasConcept C88045685 @default.
• W4206937488 hasConceptScore W4206937488C101762097 @default.
• W4206937488 hasConceptScore W4206937488C104317684 @default.
• W4206937488 hasConceptScore W4206937488C111936080 @default.
• W4206937488 hasConceptScore W4206937488C138885662 @default.
• W4206937488 hasConceptScore W4206937488C140704245 @default.
• W4206937488 hasConceptScore W4206937488C150194340 @default.
• W4206937488 hasConceptScore W4206937488C153911025 @default.
• W4206937488 hasConceptScore W4206937488C159047783 @default.
• W4206937488 hasConceptScore W4206937488C179926584 @default.
• W4206937488 hasConceptScore W4206937488C194575299 @default.

• next