Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206951644> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4206951644 abstract "Photolabile Protecting Groups (PPGs) are chemical tools used in photopharmacology for the oxygen-independent release of bioactive payloads, enabling spatiotemporal activation of their bioactivity. However, red-shifting of PPG activation wavelengths into the NIR range, light which penetrates the deepest in tissue, has been laborious, and often results in inefficient or insoluble PPGs. This challenge prohibits the use of current photocages in complex biological targets, hindering the progression of photopharmacology into the clinic. To directly address this problem, we report herein a novel concept in PPG design, by transforming clinically-applied NIR-dyes with suitable molecular orbital configurations into new NIR-PPGs using computational approaches. Using this method, we demonstrate how Cy7, a class of clinically-employed NIR dyes possessing ideal properties, such as NIR-absorption, very high molecular absorptivity, and excellent solubility in aqueous media, can be successfully converted into Cy7-PPG. We report a facile organic synthesis towards Cy7-PPG from easily accessible precursors and confirm its function as an oxygen-independent NIR-PPG. Cy7-PPG is the most redshifted PPG to date (max wavelength = 746 nm), with unmatched molecular absorptivity and solubility, and excellent uncaging efficiency, paving the way for the use of PPGs in the clinic." @default.
- W4206951644 created "2022-01-26" @default.
- W4206951644 creator A5006401636 @default.
- W4206951644 creator A5008127830 @default.
- W4206951644 creator A5017114065 @default.
- W4206951644 creator A5030298371 @default.
- W4206951644 creator A5078954465 @default.
- W4206951644 date "2022-01-25" @default.
- W4206951644 modified "2023-10-17" @default.
- W4206951644 title "Computational Design, Synthesis and Photochemistry of Cy7-PPG, an Efficient NIR-activated Photolabile Protecting Group for Therapeutic Applications" @default.
- W4206951644 doi "https://doi.org/10.26434/chemrxiv-2022-4kmm4" @default.
- W4206951644 hasPublicationYear "2022" @default.
- W4206951644 type Work @default.
- W4206951644 citedByCount "0" @default.
- W4206951644 crossrefType "posted-content" @default.
- W4206951644 hasAuthorship W4206951644A5006401636 @default.
- W4206951644 hasAuthorship W4206951644A5008127830 @default.
- W4206951644 hasAuthorship W4206951644A5017114065 @default.
- W4206951644 hasAuthorship W4206951644A5030298371 @default.
- W4206951644 hasAuthorship W4206951644A5078954465 @default.
- W4206951644 hasBestOaLocation W42069516441 @default.
- W4206951644 hasConcept C120665830 @default.
- W4206951644 hasConcept C121332964 @default.
- W4206951644 hasConcept C125287762 @default.
- W4206951644 hasConcept C155574463 @default.
- W4206951644 hasConcept C159985019 @default.
- W4206951644 hasConcept C171250308 @default.
- W4206951644 hasConcept C178790620 @default.
- W4206951644 hasConcept C185592680 @default.
- W4206951644 hasConcept C192562407 @default.
- W4206951644 hasConcept C21951064 @default.
- W4206951644 hasConcept C2992086430 @default.
- W4206951644 hasConcept C41008148 @default.
- W4206951644 hasConcept C540031477 @default.
- W4206951644 hasConcept C75473681 @default.
- W4206951644 hasConcept C76046532 @default.
- W4206951644 hasConceptScore W4206951644C120665830 @default.
- W4206951644 hasConceptScore W4206951644C121332964 @default.
- W4206951644 hasConceptScore W4206951644C125287762 @default.
- W4206951644 hasConceptScore W4206951644C155574463 @default.
- W4206951644 hasConceptScore W4206951644C159985019 @default.
- W4206951644 hasConceptScore W4206951644C171250308 @default.
- W4206951644 hasConceptScore W4206951644C178790620 @default.
- W4206951644 hasConceptScore W4206951644C185592680 @default.
- W4206951644 hasConceptScore W4206951644C192562407 @default.
- W4206951644 hasConceptScore W4206951644C21951064 @default.
- W4206951644 hasConceptScore W4206951644C2992086430 @default.
- W4206951644 hasConceptScore W4206951644C41008148 @default.
- W4206951644 hasConceptScore W4206951644C540031477 @default.
- W4206951644 hasConceptScore W4206951644C75473681 @default.
- W4206951644 hasConceptScore W4206951644C76046532 @default.
- W4206951644 hasFunder F4320307844 @default.
- W4206951644 hasFunder F4320334678 @default.
- W4206951644 hasLocation W42069516441 @default.
- W4206951644 hasLocation W42069516442 @default.
- W4206951644 hasOpenAccess W4206951644 @default.
- W4206951644 hasPrimaryLocation W42069516441 @default.
- W4206951644 hasRelatedWork W2004112662 @default.
- W4206951644 hasRelatedWork W2060518352 @default.
- W4206951644 hasRelatedWork W2087051611 @default.
- W4206951644 hasRelatedWork W2087476428 @default.
- W4206951644 hasRelatedWork W2162175307 @default.
- W4206951644 hasRelatedWork W2346094616 @default.
- W4206951644 hasRelatedWork W2748952813 @default.
- W4206951644 hasRelatedWork W2899084033 @default.
- W4206951644 hasRelatedWork W2950039976 @default.
- W4206951644 hasRelatedWork W1540019456 @default.
- W4206951644 isParatext "false" @default.
- W4206951644 isRetracted "false" @default.
- W4206951644 workType "article" @default.