FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206955754> ?p ?o ?g. }

• W4206955754 endingPage "118935" @default.
• W4206955754 startingPage "118935" @default.
• W4206955754 abstract "Disruptions in oxidative metabolism may occur in multiple sclerosis and other demyelinating neurological diseases. The impact of demyelination on metabolic rate is also not understood. It is possible that mitochondrial damage may be associated with many such neurological disorders. To study oxidative metabolism with one model of demyelination, we implemented a novel multimodal imaging technique combining Near-Infrared Spectroscopy (NIRS) and MRI to cuprizone mouse model. The cuprizone model is used to study demyelination and may be associated with inhibition of mitochondrial function. Cuprizone mice showed reduced oxygen extraction fraction (-39.1%, p ≤ 0.001), increased tissue oxygenation (6.4%, p ≤ 0.001), and reduced cerebral metabolic rate of oxygen in cortical gray matter (-62.1%, p ≤ 0.001). These changes resolved after the cessation of cuprizone exposure and partial remyelination. A decrease in hemoglobin concentration (-34.4%, p ≤ 0.001), but no change in cerebral blood flow were also observed during demyelination. The oxidized state of the mitochondrial enzyme, Cytochrome C Oxidase (CCO) increased (46.3%, p ≤ 0.001) while the reduced state decreased (-34.4%, p ≤ 0.05) significantly in cuprizone mice. The total amount of CCO did not change significantly during cuprizone exposure. Total CCO did decline after recovery both in control (-23.1%, p ≤ 0.01) and cuprizone (-28.8%, p ≤ 0.001) groups which may relate to age. A reduction in the magnetization transfer ratio, indicating demyelination, was found in the cuprizone group in the cerebral cortex (-3.2%, p ≤ 0.01) and corpus callosum (-5.5%, p ≤ 0.001). In summary, we were able to detect evidence of altered CCO metabolism during cuprizone exposure, consistent with a mitochondrial defect. We observed increased oxygenation and reduced metabolic rate associated with reduced myelination in the gray and white matter. The novel multimodal imaging technique applied here shows promise for noninvasively assessing parameters associated with oxidative metabolism in both mouse models of neurological disease and for translation to study oxidative metabolism in the human brain." @default.
• W4206955754 created "2022-01-26" @default.
• W4206955754 creator A5009632966 @default.
• W4206955754 creator A5010085174 @default.
• W4206955754 creator A5021069652 @default.
• W4206955754 creator A5069343125 @default.
• W4206955754 creator A5080330069 @default.
• W4206955754 date "2022-04-01" @default.
• W4206955754 modified "2023-09-26" @default.
• W4206955754 title "Abnormal oxidative metabolism in the cuprizone mouse model of demyelination: An in vivo NIRS-MRI study" @default.
• W4206955754 cites W1270085290 @default.
• W4206955754 cites W1482855280 @default.
• W4206955754 cites W1553875293 @default.
• W4206955754 cites W177935491 @default.
• W4206955754 cites W1870965654 @default.
• W4206955754 cites W1913796783 @default.
• W4206955754 cites W1965694489 @default.
• W4206955754 cites W1966957009 @default.
• W4206955754 cites W1967009686 @default.
• W4206955754 cites W1968478844 @default.
• W4206955754 cites W1972487406 @default.
• W4206955754 cites W1976099054 @default.
• W4206955754 cites W1978048781 @default.
• W4206955754 cites W1980808469 @default.
• W4206955754 cites W1982381404 @default.
• W4206955754 cites W1986172205 @default.
• W4206955754 cites W1988008737 @default.
• W4206955754 cites W1990544721 @default.
• W4206955754 cites W1991883207 @default.
• W4206955754 cites W1992516839 @default.
• W4206955754 cites W1994836057 @default.
• W4206955754 cites W1998057701 @default.
• W4206955754 cites W2007438030 @default.
• W4206955754 cites W2009224600 @default.
• W4206955754 cites W2012171863 @default.
• W4206955754 cites W2022848089 @default.
• W4206955754 cites W2025047388 @default.
• W4206955754 cites W2025131113 @default.
• W4206955754 cites W2028784924 @default.
• W4206955754 cites W2030806405 @default.
• W4206955754 cites W2031646822 @default.
• W4206955754 cites W2036181141 @default.
• W4206955754 cites W2036675289 @default.
• W4206955754 cites W2044439746 @default.
• W4206955754 cites W2048327558 @default.
• W4206955754 cites W2049212531 @default.
• W4206955754 cites W2050305501 @default.
• W4206955754 cites W2057093333 @default.
• W4206955754 cites W2058784068 @default.
• W4206955754 cites W2058785790 @default.
• W4206955754 cites W2059590297 @default.
• W4206955754 cites W2066463817 @default.
• W4206955754 cites W2067387849 @default.
• W4206955754 cites W2069259130 @default.
• W4206955754 cites W2072167636 @default.
• W4206955754 cites W2089730465 @default.
• W4206955754 cites W2094427913 @default.
• W4206955754 cites W2095370244 @default.
• W4206955754 cites W2100830657 @default.
• W4206955754 cites W2100904149 @default.
• W4206955754 cites W2115824887 @default.
• W4206955754 cites W2116547715 @default.
• W4206955754 cites W2123525386 @default.
• W4206955754 cites W2133249774 @default.
• W4206955754 cites W2139725823 @default.
• W4206955754 cites W2145794514 @default.
• W4206955754 cites W2147062889 @default.
• W4206955754 cites W2148353419 @default.
• W4206955754 cites W2149715738 @default.
• W4206955754 cites W2152165298 @default.
• W4206955754 cites W2154127217 @default.
• W4206955754 cites W2154165143 @default.
• W4206955754 cites W2156983722 @default.
• W4206955754 cites W2162314466 @default.
• W4206955754 cites W2261445904 @default.
• W4206955754 cites W2315326168 @default.
• W4206955754 cites W2317773438 @default.
• W4206955754 cites W2338913024 @default.
• W4206955754 cites W2343563442 @default.
• W4206955754 cites W2469475200 @default.
• W4206955754 cites W2576045109 @default.
• W4206955754 cites W2587417229 @default.
• W4206955754 cites W2761098718 @default.
• W4206955754 cites W2782358406 @default.
• W4206955754 cites W2791543465 @default.
• W4206955754 cites W2842630121 @default.
• W4206955754 cites W2883099048 @default.
• W4206955754 cites W2913897424 @default.
• W4206955754 cites W2943993219 @default.
• W4206955754 cites W2944471712 @default.
• W4206955754 cites W2966231437 @default.
• W4206955754 cites W2969951355 @default.
• W4206955754 cites W2981806491 @default.
• W4206955754 cites W2985627086 @default.
• W4206955754 cites W3014214236 @default.
• W4206955754 cites W3021163165 @default.
• W4206955754 cites W3033579374 @default.
• W4206955754 cites W3091747235 @default.

• next