Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206988816> ?p ?o ?g. }
- W4206988816 endingPage "484" @default.
- W4206988816 startingPage "484" @default.
- W4206988816 abstract "Iron and oxygen deficiencies are common features in pathophysiological conditions, such as ischemia, neurological diseases, and cancer. Cellular adaptive responses to such deficiencies include repression of mitochondrial respiration, promotion of angiogenesis, and cell cycle control. We applied a systematic proteomics analysis to determine the global proteomic changes caused by acute hypoxia and chronic and acute iron deficiency (ID) in hippocampal neuronal cells. Our analysis identified over 8600 proteins, revealing similar and differential effects of each treatment on activation and inhibition of pathways regulating neuronal development. In addition, comparative analysis of ID-induced proteomics changes in cultured cells and transcriptomic changes in the rat hippocampus identified common altered pathways, indicating specific neuronal effects. Transcription factor enrichment and correlation analysis identified key transcription factors that were activated in both cultured cells and tissue by iron deficiency, including those implicated in iron regulation, such as HIF1, NFY, and NRF1. We further identified MEF2 as a novel transcription factor whose activity was induced by ID in both HT22 proteome and rat hippocampal transcriptome, thus linking iron deficiency to MEF2-dependent cellular signaling pathways in neuronal development. Taken together, our study results identified diverse signaling networks that were differentially regulated by hypoxia and ID in neuronal cells." @default.
- W4206988816 created "2022-01-26" @default.
- W4206988816 creator A5043079934 @default.
- W4206988816 creator A5051501800 @default.
- W4206988816 creator A5061403041 @default.
- W4206988816 creator A5063211511 @default.
- W4206988816 creator A5063435261 @default.
- W4206988816 date "2022-01-13" @default.
- W4206988816 modified "2023-10-15" @default.
- W4206988816 title "Quantitative Proteome and Transcriptome Dynamics Analysis Reveals Iron Deficiency Response Networks and Signature in Neuronal Cells" @default.
- W4206988816 cites W1507819272 @default.
- W4206988816 cites W1545825939 @default.
- W4206988816 cites W1602845909 @default.
- W4206988816 cites W1902785172 @default.
- W4206988816 cites W1960924050 @default.
- W4206988816 cites W1969296748 @default.
- W4206988816 cites W1985056953 @default.
- W4206988816 cites W1991346678 @default.
- W4206988816 cites W1992193197 @default.
- W4206988816 cites W2000859982 @default.
- W4206988816 cites W2004914475 @default.
- W4206988816 cites W2008110876 @default.
- W4206988816 cites W2008622723 @default.
- W4206988816 cites W2011389660 @default.
- W4206988816 cites W2011538447 @default.
- W4206988816 cites W2027345480 @default.
- W4206988816 cites W2035175908 @default.
- W4206988816 cites W2036321220 @default.
- W4206988816 cites W2036784794 @default.
- W4206988816 cites W2047845605 @default.
- W4206988816 cites W2047969741 @default.
- W4206988816 cites W2049917711 @default.
- W4206988816 cites W2052365638 @default.
- W4206988816 cites W2060254175 @default.
- W4206988816 cites W2080752012 @default.
- W4206988816 cites W2085609942 @default.
- W4206988816 cites W2096588508 @default.
- W4206988816 cites W2100503932 @default.
- W4206988816 cites W2103017472 @default.
- W4206988816 cites W2115820946 @default.
- W4206988816 cites W2116991069 @default.
- W4206988816 cites W2126516300 @default.
- W4206988816 cites W2135836641 @default.
- W4206988816 cites W2138255346 @default.
- W4206988816 cites W2140946052 @default.
- W4206988816 cites W2146673809 @default.
- W4206988816 cites W2148614612 @default.
- W4206988816 cites W2150007817 @default.
- W4206988816 cites W2157050521 @default.
- W4206988816 cites W2159482845 @default.
- W4206988816 cites W2160377086 @default.
- W4206988816 cites W2162527851 @default.
- W4206988816 cites W2163431685 @default.
- W4206988816 cites W2168908854 @default.
- W4206988816 cites W2273908066 @default.
- W4206988816 cites W2292939138 @default.
- W4206988816 cites W2525173725 @default.
- W4206988816 cites W2546649721 @default.
- W4206988816 cites W2580449060 @default.
- W4206988816 cites W2595696124 @default.
- W4206988816 cites W2611696724 @default.
- W4206988816 cites W2765172502 @default.
- W4206988816 cites W2765242536 @default.
- W4206988816 cites W277974611 @default.
- W4206988816 cites W2896100774 @default.
- W4206988816 cites W2898402099 @default.
- W4206988816 cites W2899671176 @default.
- W4206988816 cites W2902129086 @default.
- W4206988816 cites W2928665623 @default.
- W4206988816 cites W2945846549 @default.
- W4206988816 cites W2946173685 @default.
- W4206988816 cites W2953792704 @default.
- W4206988816 cites W3009946795 @default.
- W4206988816 cites W3039938431 @default.
- W4206988816 cites W3080642888 @default.
- W4206988816 cites W3118632400 @default.
- W4206988816 cites W3205896414 @default.
- W4206988816 cites W4256409604 @default.
- W4206988816 doi "https://doi.org/10.3390/molecules27020484" @default.
- W4206988816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35056799" @default.
- W4206988816 hasPublicationYear "2022" @default.
- W4206988816 type Work @default.
- W4206988816 citedByCount "2" @default.
- W4206988816 countsByYear W42069888162023 @default.
- W4206988816 crossrefType "journal-article" @default.
- W4206988816 hasAuthorship W4206988816A5043079934 @default.
- W4206988816 hasAuthorship W4206988816A5051501800 @default.
- W4206988816 hasAuthorship W4206988816A5061403041 @default.
- W4206988816 hasAuthorship W4206988816A5063211511 @default.
- W4206988816 hasAuthorship W4206988816A5063435261 @default.
- W4206988816 hasBestOaLocation W42069888161 @default.
- W4206988816 hasConcept C104317684 @default.
- W4206988816 hasConcept C104397665 @default.
- W4206988816 hasConcept C150194340 @default.
- W4206988816 hasConcept C160450060 @default.
- W4206988816 hasConcept C162317418 @default.
- W4206988816 hasConcept C46111723 @default.
- W4206988816 hasConcept C54355233 @default.