Matches in SemOpenAlex for { <https://semopenalex.org/work/W4206994200> ?p ?o ?g. }
- W4206994200 endingPage "140" @default.
- W4206994200 startingPage "125" @default.
- W4206994200 abstract "Abstract Cannabis is now legal in many countries and while numerous studies have reported on its impact on cognition and appetite regulation, none have examined fatty acid metabolism in young cannabis users. We conducted an exploratory analysis to evaluate cannabis impact on fatty acid metabolism in cannabis users ( n = 21) and non‐cannabis users ( n = 16). Serum levels of some saturated and monounsaturated fatty acids, including palmitic, palmitoleic, and oleic acids were higher in cannabis users compared to nonusers. As palmitic acid can be derived from diet or lipogenesis from sugars, we evaluated lipogenesis using a de novo lipogenesis index (palmitate/linoleic acid) and carbon‐specific isotope analysis, which allows for the determination of fatty acid 13 C signature. The significantly higher de novo lipogenesis index in the cannabis users group along with a more enriched 13 C signature of palmitic acid suggested an increase in lipogenesis. In addition, while serum glucose concentration did not differ between groups, pyruvate and lactate were lower in the cannabis user group, with pyruvate negatively correlating with palmitic acid. Furthermore, the endocannabinoid 2‐arachidonoylglycerol was elevated in cannabis users and could contribute to lipogenesis by activating the cannabinoid receptor 1. Because palmitic acid has been suggested to increase inflammation, we measured peripheral cytokines and observed no changes in inflammatory cytokines. Finally, an anti‐inflammatory metabolite of palmitic acid, palmitoylethanolamide was elevated in cannabis users. Our results suggest that lipogenic activity is increased in cannabis users; however, future studies, including prospective studies that control dietary intake are required." @default.
- W4206994200 created "2022-01-26" @default.
- W4206994200 creator A5007960413 @default.
- W4206994200 creator A5014756145 @default.
- W4206994200 creator A5027965558 @default.
- W4206994200 creator A5028551712 @default.
- W4206994200 creator A5039322135 @default.
- W4206994200 creator A5058357832 @default.
- W4206994200 creator A5073234834 @default.
- W4206994200 creator A5076994005 @default.
- W4206994200 date "2022-01-24" @default.
- W4206994200 modified "2023-10-17" @default.
- W4206994200 title "Serum lipid analysis and isotopic enrichment is suggestive of greater lipogenesis in young long‐term cannabis users: A secondary analysis of a case–control study" @default.
- W4206994200 cites W1491109154 @default.
- W4206994200 cites W1513639150 @default.
- W4206994200 cites W1886084954 @default.
- W4206994200 cites W1909115912 @default.
- W4206994200 cites W1973299307 @default.
- W4206994200 cites W1978224806 @default.
- W4206994200 cites W1979514172 @default.
- W4206994200 cites W1980233888 @default.
- W4206994200 cites W1986723954 @default.
- W4206994200 cites W2001474776 @default.
- W4206994200 cites W2003347868 @default.
- W4206994200 cites W2005418044 @default.
- W4206994200 cites W2015614945 @default.
- W4206994200 cites W2016954847 @default.
- W4206994200 cites W2019207756 @default.
- W4206994200 cites W2030623240 @default.
- W4206994200 cites W2032755630 @default.
- W4206994200 cites W2042180479 @default.
- W4206994200 cites W2048035276 @default.
- W4206994200 cites W2050024623 @default.
- W4206994200 cites W2056416370 @default.
- W4206994200 cites W2057103413 @default.
- W4206994200 cites W2068481683 @default.
- W4206994200 cites W2073734463 @default.
- W4206994200 cites W2081987813 @default.
- W4206994200 cites W2084882106 @default.
- W4206994200 cites W2085983759 @default.
- W4206994200 cites W2086943531 @default.
- W4206994200 cites W2087281728 @default.
- W4206994200 cites W2094939361 @default.
- W4206994200 cites W2097472057 @default.
- W4206994200 cites W2105283833 @default.
- W4206994200 cites W2113208048 @default.
- W4206994200 cites W2113834749 @default.
- W4206994200 cites W2117507851 @default.
- W4206994200 cites W2126847200 @default.
- W4206994200 cites W2128321311 @default.
- W4206994200 cites W2133811076 @default.
- W4206994200 cites W2141972883 @default.
- W4206994200 cites W2145590356 @default.
- W4206994200 cites W2152281174 @default.
- W4206994200 cites W2158243368 @default.
- W4206994200 cites W2160357758 @default.
- W4206994200 cites W2161744092 @default.
- W4206994200 cites W2168526937 @default.
- W4206994200 cites W2411815569 @default.
- W4206994200 cites W2514007471 @default.
- W4206994200 cites W2518461429 @default.
- W4206994200 cites W2519614703 @default.
- W4206994200 cites W2609660872 @default.
- W4206994200 cites W2734927163 @default.
- W4206994200 cites W2743995251 @default.
- W4206994200 cites W2770989366 @default.
- W4206994200 cites W2799699985 @default.
- W4206994200 cites W2808956335 @default.
- W4206994200 cites W2809659531 @default.
- W4206994200 cites W2895842827 @default.
- W4206994200 cites W2903042028 @default.
- W4206994200 cites W2945857771 @default.
- W4206994200 cites W2950355808 @default.
- W4206994200 cites W2951909509 @default.
- W4206994200 cites W2952928229 @default.
- W4206994200 cites W2953991849 @default.
- W4206994200 cites W2964783773 @default.
- W4206994200 cites W2967721044 @default.
- W4206994200 cites W2973684037 @default.
- W4206994200 cites W2974852172 @default.
- W4206994200 cites W3002634800 @default.
- W4206994200 cites W3009123353 @default.
- W4206994200 cites W3011210198 @default.
- W4206994200 cites W3040293001 @default.
- W4206994200 cites W3041167958 @default.
- W4206994200 cites W3096725799 @default.
- W4206994200 cites W3124080712 @default.
- W4206994200 cites W4210836735 @default.
- W4206994200 cites W4248980229 @default.
- W4206994200 cites W2416299033 @default.
- W4206994200 doi "https://doi.org/10.1002/lipd.12336" @default.
- W4206994200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35075659" @default.
- W4206994200 hasPublicationYear "2022" @default.
- W4206994200 type Work @default.
- W4206994200 citedByCount "2" @default.
- W4206994200 countsByYear W42069942002023 @default.
- W4206994200 crossrefType "journal-article" @default.
- W4206994200 hasAuthorship W4206994200A5007960413 @default.