Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207003689> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4207003689 abstract "Abstract Enterovirus A71 (EV-A71) is an emerging enterovirus that can cause neurological complications in young children. The severity of EV71 infection is correlated with the production of cytokines, including IL-6 and IL-1b. Macrophages are specialized immune cells that have been deemed the major cell source for IL-1b. The production of IL-1b is a result of inflammasome activation, an innate immune response that involves the assembly of multiple proteins. However, the mechanisms by which EV-A71 activates inflammasomes are not fully understood. Here, we confirmed that THP-1 macrophages permissive EV-A71 replication. EV-A71 infection is sufficient to trigger IL-1b production in macrophages. Knockdown of NLRP3, RIG-I and TLR3 in macrophages suppressed IL-1b secretion. Moreover, caspase-1 and caspase-8 activation are involved in IL-1b production. In summary, this study showed that NLRP3 and the RNA sensors TLR3 and RIG-I are implicated in EV-A71-induced inflammasome activation in macrophages to facilitate IL-1b production via activated caspase-1 and caspase-8." @default.
- W4207003689 created "2022-01-26" @default.
- W4207003689 creator A5017020876 @default.
- W4207003689 creator A5020198575 @default.
- W4207003689 creator A5024125211 @default.
- W4207003689 creator A5037251833 @default.
- W4207003689 creator A5058137324 @default.
- W4207003689 creator A5076417814 @default.
- W4207003689 date "2022-01-25" @default.
- W4207003689 modified "2023-10-17" @default.
- W4207003689 title "EV-A71 Induced IL-1Beta Production in THP-1 Macrophages is Dependent on NLRP3, RIG-I, and TLR3" @default.
- W4207003689 doi "https://doi.org/10.21203/rs.3.rs-1246588/v1" @default.
- W4207003689 hasPublicationYear "2022" @default.
- W4207003689 type Work @default.
- W4207003689 citedByCount "0" @default.
- W4207003689 crossrefType "posted-content" @default.
- W4207003689 hasAuthorship W4207003689A5017020876 @default.
- W4207003689 hasAuthorship W4207003689A5020198575 @default.
- W4207003689 hasAuthorship W4207003689A5024125211 @default.
- W4207003689 hasAuthorship W4207003689A5037251833 @default.
- W4207003689 hasAuthorship W4207003689A5058137324 @default.
- W4207003689 hasAuthorship W4207003689A5076417814 @default.
- W4207003689 hasBestOaLocation W42070036891 @default.
- W4207003689 hasConcept C136449434 @default.
- W4207003689 hasConcept C139964883 @default.
- W4207003689 hasConcept C173396325 @default.
- W4207003689 hasConcept C185592680 @default.
- W4207003689 hasConcept C190283241 @default.
- W4207003689 hasConcept C203014093 @default.
- W4207003689 hasConcept C204258353 @default.
- W4207003689 hasConcept C2522874641 @default.
- W4207003689 hasConcept C2776709828 @default.
- W4207003689 hasConcept C2776914184 @default.
- W4207003689 hasConcept C2777209026 @default.
- W4207003689 hasConcept C2777888124 @default.
- W4207003689 hasConcept C2778420691 @default.
- W4207003689 hasConcept C49039625 @default.
- W4207003689 hasConcept C54355233 @default.
- W4207003689 hasConcept C55493867 @default.
- W4207003689 hasConcept C81885089 @default.
- W4207003689 hasConcept C86803240 @default.
- W4207003689 hasConcept C8891405 @default.
- W4207003689 hasConcept C95444343 @default.
- W4207003689 hasConceptScore W4207003689C136449434 @default.
- W4207003689 hasConceptScore W4207003689C139964883 @default.
- W4207003689 hasConceptScore W4207003689C173396325 @default.
- W4207003689 hasConceptScore W4207003689C185592680 @default.
- W4207003689 hasConceptScore W4207003689C190283241 @default.
- W4207003689 hasConceptScore W4207003689C203014093 @default.
- W4207003689 hasConceptScore W4207003689C204258353 @default.
- W4207003689 hasConceptScore W4207003689C2522874641 @default.
- W4207003689 hasConceptScore W4207003689C2776709828 @default.
- W4207003689 hasConceptScore W4207003689C2776914184 @default.
- W4207003689 hasConceptScore W4207003689C2777209026 @default.
- W4207003689 hasConceptScore W4207003689C2777888124 @default.
- W4207003689 hasConceptScore W4207003689C2778420691 @default.
- W4207003689 hasConceptScore W4207003689C49039625 @default.
- W4207003689 hasConceptScore W4207003689C54355233 @default.
- W4207003689 hasConceptScore W4207003689C55493867 @default.
- W4207003689 hasConceptScore W4207003689C81885089 @default.
- W4207003689 hasConceptScore W4207003689C86803240 @default.
- W4207003689 hasConceptScore W4207003689C8891405 @default.
- W4207003689 hasConceptScore W4207003689C95444343 @default.
- W4207003689 hasLocation W42070036891 @default.
- W4207003689 hasOpenAccess W4207003689 @default.
- W4207003689 hasPrimaryLocation W42070036891 @default.
- W4207003689 hasRelatedWork W2064319114 @default.
- W4207003689 hasRelatedWork W2522681982 @default.
- W4207003689 hasRelatedWork W2741813146 @default.
- W4207003689 hasRelatedWork W2780532061 @default.
- W4207003689 hasRelatedWork W2810574398 @default.
- W4207003689 hasRelatedWork W2887547606 @default.
- W4207003689 hasRelatedWork W2893709640 @default.
- W4207003689 hasRelatedWork W3174313729 @default.
- W4207003689 hasRelatedWork W4207003689 @default.
- W4207003689 hasRelatedWork W4311674744 @default.
- W4207003689 isParatext "false" @default.
- W4207003689 isRetracted "false" @default.
- W4207003689 workType "article" @default.