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- W4207008623 abstract "Intercellular transfer of toxic proteins between neurons is thought to contribute to neurodegenerative disease, but whether direct interneuronal protein transfer occurs in the healthy brain is not clear. To assess the prevalence and identity of transferred proteins and the cellular specificity of transfer, we biotinylated retinal ganglion cell proteins in vivo and examined biotinylated proteins transported through the rodent visual circuit using microscopy, biochemistry, and mass spectrometry. Electron microscopy demonstrated preferential transfer of biotinylated proteins from retinogeniculate inputs to excitatory lateral geniculate nucleus (LGN) neurons compared with GABAergic neurons. An unbiased mass spectrometry-based screen identified ∼200 transneuronally transported proteins (TNTPs) isolated from the visual cortex. The majority of TNTPs are present in neuronal exosomes, and virally expressed TNTPs, including tau and β-synuclein, were detected in isolated exosomes and postsynaptic neurons. Our data demonstrate transfer of diverse endogenous proteins between neurons in the healthy intact brain and suggest that TNTP transport may be mediated by exosomes." @default.
- W4207008623 created "2022-01-26" @default.
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- W4207008623 date "2022-01-01" @default.
- W4207008623 modified "2023-10-16" @default.
- W4207008623 title "Proteomic screen reveals diverse protein transport between connected neurons in the visual system" @default.
- W4207008623 cites W1175020023 @default.
- W4207008623 cites W124481901 @default.
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- W4207008623 cites W1496088120 @default.
- W4207008623 cites W1530468053 @default.
- W4207008623 cites W1966497031 @default.
- W4207008623 cites W1968502711 @default.
- W4207008623 cites W1970085309 @default.
- W4207008623 cites W1973319971 @default.
- W4207008623 cites W1992352812 @default.
- W4207008623 cites W1999408122 @default.
- W4207008623 cites W2001308817 @default.
- W4207008623 cites W2007570014 @default.
- W4207008623 cites W2015207902 @default.
- W4207008623 cites W2015800370 @default.
- W4207008623 cites W2016748026 @default.
- W4207008623 cites W2019612613 @default.
- W4207008623 cites W2021836199 @default.
- W4207008623 cites W2023869222 @default.
- W4207008623 cites W2026634592 @default.
- W4207008623 cites W2026789878 @default.
- W4207008623 cites W2032912341 @default.
- W4207008623 cites W2036962817 @default.
- W4207008623 cites W2052930127 @default.
- W4207008623 cites W2053082937 @default.
- W4207008623 cites W2057518946 @default.
- W4207008623 cites W2059539850 @default.
- W4207008623 cites W2060780830 @default.
- W4207008623 cites W2065236536 @default.
- W4207008623 cites W2071087722 @default.
- W4207008623 cites W2073374905 @default.
- W4207008623 cites W2073449985 @default.
- W4207008623 cites W2076891899 @default.
- W4207008623 cites W2077047479 @default.
- W4207008623 cites W2086207981 @default.
- W4207008623 cites W2095963715 @default.
- W4207008623 cites W2097469682 @default.
- W4207008623 cites W2097760882 @default.
- W4207008623 cites W2103017472 @default.
- W4207008623 cites W2104135721 @default.
- W4207008623 cites W2104994386 @default.
- W4207008623 cites W2115746733 @default.
- W4207008623 cites W2126614737 @default.
- W4207008623 cites W2134157741 @default.
- W4207008623 cites W2137096994 @default.
- W4207008623 cites W2138435892 @default.
- W4207008623 cites W2147193337 @default.
- W4207008623 cites W2147530111 @default.
- W4207008623 cites W2150947848 @default.
- W4207008623 cites W2161334375 @default.
- W4207008623 cites W2163500926 @default.
- W4207008623 cites W2163895781 @default.
- W4207008623 cites W2167565828 @default.
- W4207008623 cites W2182963873 @default.
- W4207008623 cites W2217609893 @default.
- W4207008623 cites W2280881439 @default.
- W4207008623 cites W2512007269 @default.
- W4207008623 cites W2537623931 @default.
- W4207008623 cites W2574784626 @default.
- W4207008623 cites W2596953817 @default.
- W4207008623 cites W265464850 @default.
- W4207008623 cites W2784776166 @default.
- W4207008623 cites W2900044275 @default.
- W4207008623 cites W2900966547 @default.
- W4207008623 cites W2904794894 @default.
- W4207008623 cites W2941704007 @default.
- W4207008623 cites W2948949781 @default.
- W4207008623 cites W2950595506 @default.
- W4207008623 cites W2959379447 @default.
- W4207008623 cites W2967067107 @default.
- W4207008623 cites W2995145713 @default.
- W4207008623 cites W3034248495 @default.
- W4207008623 cites W3122078386 @default.
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- W4207008623 doi "https://doi.org/10.1016/j.celrep.2021.110287" @default.
- W4207008623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35081342" @default.
- W4207008623 hasPublicationYear "2022" @default.
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