Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207013700> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4207013700 abstract "Transcription factor IID (TFIID) recognizes core promoters and supports preinitiation complex (PIC) assembly for RNA polymerase II (Pol II)-mediated eukaryotic transcription. We determined the structures of human TFIID-based PIC in three stepwise assembly states and revealed two-track PIC assembly: stepwise promoter deposition to Pol II and extensive modular reorganization on track I (on TATA-TFIID-binding element promoters) versus direct promoter deposition on track II (on TATA-only and TATA-less promoters). The two tracks converge at an ~50-subunit holo PIC in identical conformation, whereby TFIID stabilizes PIC organization and supports loading of cyclin-dependent kinase (CDK)-activating kinase (CAK) onto Pol II and CAK-mediated phosphorylation of the Pol II carboxyl-terminal domain. Unexpectedly, TBP of TFIID similarly bends TATA box and TATA-less promoters in PIC. Our study provides structural visualization of stepwise PIC assembly on highly diversified promoters.Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. PMID: 33795473" @default.
- W4207013700 created "2022-01-26" @default.
- W4207013700 creator A5017404099 @default.
- W4207013700 date "2021-04-15" @default.
- W4207013700 modified "2023-10-18" @default.
- W4207013700 title "Faculty Opinions recommendation of Structural insights into preinitiation complex assembly on core promoters." @default.
- W4207013700 doi "https://doi.org/10.3410/f.739855679.793584710" @default.
- W4207013700 hasPublicationYear "2021" @default.
- W4207013700 type Work @default.
- W4207013700 citedByCount "0" @default.
- W4207013700 crossrefType "dataset" @default.
- W4207013700 hasAuthorship W4207013700A5017404099 @default.
- W4207013700 hasConcept C101762097 @default.
- W4207013700 hasConcept C102622118 @default.
- W4207013700 hasConcept C104317684 @default.
- W4207013700 hasConcept C150194340 @default.
- W4207013700 hasConcept C172768829 @default.
- W4207013700 hasConcept C188740287 @default.
- W4207013700 hasConcept C44498088 @default.
- W4207013700 hasConcept C54355233 @default.
- W4207013700 hasConcept C64350747 @default.
- W4207013700 hasConcept C65888428 @default.
- W4207013700 hasConcept C86803240 @default.
- W4207013700 hasConcept C95444343 @default.
- W4207013700 hasConceptScore W4207013700C101762097 @default.
- W4207013700 hasConceptScore W4207013700C102622118 @default.
- W4207013700 hasConceptScore W4207013700C104317684 @default.
- W4207013700 hasConceptScore W4207013700C150194340 @default.
- W4207013700 hasConceptScore W4207013700C172768829 @default.
- W4207013700 hasConceptScore W4207013700C188740287 @default.
- W4207013700 hasConceptScore W4207013700C44498088 @default.
- W4207013700 hasConceptScore W4207013700C54355233 @default.
- W4207013700 hasConceptScore W4207013700C64350747 @default.
- W4207013700 hasConceptScore W4207013700C65888428 @default.
- W4207013700 hasConceptScore W4207013700C86803240 @default.
- W4207013700 hasConceptScore W4207013700C95444343 @default.
- W4207013700 hasLocation W42070137001 @default.
- W4207013700 hasOpenAccess W4207013700 @default.
- W4207013700 hasPrimaryLocation W42070137001 @default.
- W4207013700 hasRelatedWork W1264979566 @default.
- W4207013700 hasRelatedWork W1605214441 @default.
- W4207013700 hasRelatedWork W2026965606 @default.
- W4207013700 hasRelatedWork W2101341060 @default.
- W4207013700 hasRelatedWork W2142366629 @default.
- W4207013700 hasRelatedWork W2160211076 @default.
- W4207013700 hasRelatedWork W2753104575 @default.
- W4207013700 hasRelatedWork W3147847912 @default.
- W4207013700 hasRelatedWork W3159326958 @default.
- W4207013700 hasRelatedWork W4290989069 @default.
- W4207013700 isParatext "false" @default.
- W4207013700 isRetracted "false" @default.
- W4207013700 workType "dataset" @default.