Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207014158> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4207014158 abstract "Early-onset sepsis results in increased morbidity and mortality in preterm infants. Antimicrobial Stewardship Programs (ASPs) address the need to balance adverse effects of antibiotic exposure with the need for empiric treatment for infants at the highest risk for early-onset sepsis.All preterm infants <34 weeks gestational age born during a 6-month period before (January 2017-June 2017) and a 6-month period after (January 2019-June 2019) implementation of ASP in May 2018 were reviewed. The presence of perinatal sepsis risk factors, eligibility for, versus treatment with initial empiric antibiotics was compared.Our cohort comprised 479 infants with a mean of 30 weeks gestation and birth weight of 1400 g. Demographics were comparable, with more Cesarean section deliveries in the post-ASP cohort. Any sepsis risk factor was present in 73.6% versus 68.4% in the pre- versus post-ASP cohorts (P = 0.23). Fewer infants were treated with antibiotics in the later cohort (60.4%) compared with the earlier cohort (69.7%; P = 0.04). Despite the presence of risk factors (preterm labor in 93% and rupture of membranes in 60%), 42% of infants did not receive initial antibiotics. Twenty percent with no perinatal sepsis risk factors were deemed low-risk and not treated.Implementation of a neonatal ASP decreased antibiotic initiation at birth. Antibiotic use decreased (appropriately) in the subgroup with no perinatal sepsis risk factors. Of concern, some infants were not treated despite risk factors, such as preterm labor/rupture of membrane. Neonatal ASP teams need to be aware of potentially unintended consequences of their initiatives." @default.
- W4207014158 created "2022-01-26" @default.
- W4207014158 creator A5019037261 @default.
- W4207014158 creator A5029668897 @default.
- W4207014158 creator A5033975672 @default.
- W4207014158 creator A5035177531 @default.
- W4207014158 creator A5041052737 @default.
- W4207014158 creator A5046492941 @default.
- W4207014158 creator A5064234912 @default.
- W4207014158 creator A5087354963 @default.
- W4207014158 date "2022-01-21" @default.
- W4207014158 modified "2023-09-27" @default.
- W4207014158 title "Antimicrobial Stewardship at Birth in Preterm Infants" @default.
- W4207014158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35067640" @default.
- W4207014158 hasPublicationYear "2022" @default.
- W4207014158 type Work @default.
- W4207014158 citedByCount "0" @default.
- W4207014158 crossrefType "journal-article" @default.
- W4207014158 hasAuthorship W4207014158A5019037261 @default.
- W4207014158 hasAuthorship W4207014158A5029668897 @default.
- W4207014158 hasAuthorship W4207014158A5033975672 @default.
- W4207014158 hasAuthorship W4207014158A5035177531 @default.
- W4207014158 hasAuthorship W4207014158A5041052737 @default.
- W4207014158 hasAuthorship W4207014158A5046492941 @default.
- W4207014158 hasAuthorship W4207014158A5064234912 @default.
- W4207014158 hasAuthorship W4207014158A5087354963 @default.
- W4207014158 hasConcept C126322002 @default.
- W4207014158 hasConcept C131872663 @default.
- W4207014158 hasConcept C187212893 @default.
- W4207014158 hasConcept C201903717 @default.
- W4207014158 hasConcept C2775953899 @default.
- W4207014158 hasConcept C2778376644 @default.
- W4207014158 hasConcept C2778384902 @default.
- W4207014158 hasConcept C2779083892 @default.
- W4207014158 hasConcept C2779234561 @default.
- W4207014158 hasConcept C501593827 @default.
- W4207014158 hasConcept C50440223 @default.
- W4207014158 hasConcept C54355233 @default.
- W4207014158 hasConcept C66322754 @default.
- W4207014158 hasConcept C71924100 @default.
- W4207014158 hasConcept C72563966 @default.
- W4207014158 hasConcept C86803240 @default.
- W4207014158 hasConcept C89423630 @default.
- W4207014158 hasConceptScore W4207014158C126322002 @default.
- W4207014158 hasConceptScore W4207014158C131872663 @default.
- W4207014158 hasConceptScore W4207014158C187212893 @default.
- W4207014158 hasConceptScore W4207014158C201903717 @default.
- W4207014158 hasConceptScore W4207014158C2775953899 @default.
- W4207014158 hasConceptScore W4207014158C2778376644 @default.
- W4207014158 hasConceptScore W4207014158C2778384902 @default.
- W4207014158 hasConceptScore W4207014158C2779083892 @default.
- W4207014158 hasConceptScore W4207014158C2779234561 @default.
- W4207014158 hasConceptScore W4207014158C501593827 @default.
- W4207014158 hasConceptScore W4207014158C50440223 @default.
- W4207014158 hasConceptScore W4207014158C54355233 @default.
- W4207014158 hasConceptScore W4207014158C66322754 @default.
- W4207014158 hasConceptScore W4207014158C71924100 @default.
- W4207014158 hasConceptScore W4207014158C72563966 @default.
- W4207014158 hasConceptScore W4207014158C86803240 @default.
- W4207014158 hasConceptScore W4207014158C89423630 @default.
- W4207014158 hasOpenAccess W4207014158 @default.
- W4207014158 hasRelatedWork W13285608 @default.
- W4207014158 hasRelatedWork W15367070 @default.
- W4207014158 hasRelatedWork W16590230 @default.
- W4207014158 hasRelatedWork W1886441 @default.
- W4207014158 hasRelatedWork W4479724 @default.
- W4207014158 hasRelatedWork W6095488 @default.
- W4207014158 hasRelatedWork W7758540 @default.
- W4207014158 hasRelatedWork W8678125 @default.
- W4207014158 hasRelatedWork W8953132 @default.
- W4207014158 hasRelatedWork W1119651 @default.
- W4207014158 hasVolume "Publish Ahead of Print" @default.
- W4207014158 isParatext "false" @default.
- W4207014158 isRetracted "false" @default.
- W4207014158 workType "article" @default.