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- W4207020033 abstract "The oxidative decarboxylation of coproheme to form heme b by coproheme decarboxylase is a stereospecific two-step reaction. In the first step, the propionate at position two (p2) is cleaved off the pyrrole ring A to form a vinyl group at this position. Subsequently, the propionate at position four (p4) on pyrrole ring B is cleaved off and heme b is formed. In this study, we attempted to engineer coproheme decarboxylase from Corynebacterium diphtheriae to alter the stereospecificity of this reaction. By introducing a tyrosine residue in proximity to the propionate at position 4, we were able to create a new radical center in the active site. However, the artificial Tyr183 • radical could not be shown to catalyze any decarboxylation." @default.
- W4207020033 created "2022-01-26" @default.
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- W4207020033 date "2022-01-24" @default.
- W4207020033 modified "2023-10-14" @default.
- W4207020033 title "Initial Steps to Engineer Coproheme Decarboxylase to Obtain Stereospecific Monovinyl, Monopropionyl Deuterohemes" @default.
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- W4207020033 doi "https://doi.org/10.3389/fbioe.2021.807678" @default.
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