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- W4207021235 abstract "Opioid receptors (ORs) precisely modulate behavior when activated by native peptide ligands but distort behaviors to produce pathology when activated by non-peptide drugs. A fundamental question is how drugs differ from peptides in their actions on target neurons. Here, we show that drugs differ in the subcellular location at which they activate ORs. We develop a genetically encoded biosensor that directly detects ligand-induced activation of ORs and uncover a real-time map of the spatiotemporal organization of OR activation in living neurons. Peptide agonists produce a characteristic activation pattern initiated in the plasma membrane and propagating to endosomes after receptor internalization. Drugs produce a different activation pattern by additionally driving OR activation in the somatic Golgi apparatus and Golgi elements extending throughout the dendritic arbor. These results establish an approach to probe the cellular basis of neuromodulation and reveal that drugs distort the spatiotemporal landscape of neuronal OR activation.Copyright © 2018 Elsevier Inc. All rights reserved. PMID: 29754753 Funding information This work was supported by: NIDA NIH HHS, United States Grant ID: R01 DA010711 NINDS NIH HHS, United States Grant ID: U01 NS103522 NIDA NIH HHS, United States Grant ID: R37 DA010711 NIDA NIH HHS, United States Grant ID: R01 DA034388 NIDA NIH HHS, United States Grant ID: R01 DA012864 NIDA NIH HHS, United States Grant ID: R37 DA004443 NIDA NIH HHS, United States Grant ID: R29 DA010711 NIDA NIH HHS, United States Grant ID: R01 DA004443 More Less keyboard_arrow_down" @default.
- W4207021235 created "2022-01-26" @default.
- W4207021235 creator A5065409960 @default.
- W4207021235 date "2021-01-19" @default.
- W4207021235 modified "2023-09-27" @default.
- W4207021235 title "Faculty Opinions recommendation of A genetically encoded biosensor reveals location bias of opioid drug action." @default.
- W4207021235 doi "https://doi.org/10.3410/f.733208852.793581996" @default.
- W4207021235 hasPublicationYear "2021" @default.
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