Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207028823> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4207028823 abstract "Accumulating evidence demonstrates that long non-coding RNAs (lncRNAs) are associated with the development of osteoporosis. The present study aimed to investigate the effect of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) on osteogenic differentiation in osteoporosis.MALAT1 levels were detected by a real-time polymerase chain reaction (RT-qPCR). Moreover, the levels of osteogenic differentiation-related factors (Bmp4, Col1a1 and Spp1) were measured by a RT-qPCR and western blotting. Alkaline phosphatase (ALP) activity was detected using an ALP staining assay.MALAT1 levels were downregulated in hindlimb unloading mice and simulated in microgravity (MG) treated MC3T3-E1 cells. Moreover, MG treatment induced the downregulation of the expression of ALP, BMP4, Col1a1 and Spp1, whereas overexpression of MALAT1 abolished the downregulation. MG also inhibited ALP activity, whereas MALAT1 reversed the effect. Furthermore, miR-217 was identified as a target of MALAT1, and AKT3 was verified as a target of miR-217. Overexpression of miR-217 rescued the promotion of osteogenic differentiation induced by MALAT1 in MG treated cells. Knockdown of AKT3 abolished the facilitation of osteogenic differentiation induced by downregulation of miR-217.MALAT1 promotes osteogenic differentiation through regulating miR-217/AKT3 axis, suggesting that MALAT1 is a potential target with respect to alleviating osteoporosis." @default.
- W4207028823 created "2022-01-26" @default.
- W4207028823 creator A5004793773 @default.
- W4207028823 creator A5017901330 @default.
- W4207028823 creator A5043382324 @default.
- W4207028823 creator A5076551695 @default.
- W4207028823 date "2022-05-06" @default.
- W4207028823 modified "2023-10-16" @default.
- W4207028823 title "lncRNA MALAT1 promotes osteogenic differentiation through the miR‐217/AKT3 axis: A possible strategy to alleviate osteoporosis" @default.
- W4207028823 cites W1984621921 @default.
- W4207028823 cites W2019582558 @default.
- W4207028823 cites W2065742010 @default.
- W4207028823 cites W2073747772 @default.
- W4207028823 cites W2151258296 @default.
- W4207028823 cites W2153268494 @default.
- W4207028823 cites W2165868202 @default.
- W4207028823 cites W2282084472 @default.
- W4207028823 cites W2528785712 @default.
- W4207028823 cites W2586409573 @default.
- W4207028823 cites W2598220367 @default.
- W4207028823 cites W2610405998 @default.
- W4207028823 cites W2726543335 @default.
- W4207028823 cites W2801962972 @default.
- W4207028823 cites W2899949902 @default.
- W4207028823 cites W2955802364 @default.
- W4207028823 cites W2982103201 @default.
- W4207028823 cites W3034094113 @default.
- W4207028823 cites W3035249160 @default.
- W4207028823 cites W3080778385 @default.
- W4207028823 cites W3087438346 @default.
- W4207028823 cites W3092466911 @default.
- W4207028823 cites W3097723556 @default.
- W4207028823 cites W3100680063 @default.
- W4207028823 cites W3186083951 @default.
- W4207028823 cites W4242687626 @default.
- W4207028823 doi "https://doi.org/10.1002/jgm.3409" @default.
- W4207028823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35030644" @default.
- W4207028823 hasPublicationYear "2022" @default.
- W4207028823 type Work @default.
- W4207028823 citedByCount "9" @default.
- W4207028823 countsByYear W42070288232022 @default.
- W4207028823 countsByYear W42070288232023 @default.
- W4207028823 crossrefType "journal-article" @default.
- W4207028823 hasAuthorship W4207028823A5004793773 @default.
- W4207028823 hasAuthorship W4207028823A5017901330 @default.
- W4207028823 hasAuthorship W4207028823A5043382324 @default.
- W4207028823 hasAuthorship W4207028823A5076551695 @default.
- W4207028823 hasConcept C104317684 @default.
- W4207028823 hasConcept C127561419 @default.
- W4207028823 hasConcept C160160445 @default.
- W4207028823 hasConcept C173396325 @default.
- W4207028823 hasConcept C181199279 @default.
- W4207028823 hasConcept C185592680 @default.
- W4207028823 hasConcept C190283241 @default.
- W4207028823 hasConcept C2776941990 @default.
- W4207028823 hasConcept C2779134362 @default.
- W4207028823 hasConcept C502942594 @default.
- W4207028823 hasConcept C55493867 @default.
- W4207028823 hasConcept C62203573 @default.
- W4207028823 hasConcept C86803240 @default.
- W4207028823 hasConcept C95444343 @default.
- W4207028823 hasConceptScore W4207028823C104317684 @default.
- W4207028823 hasConceptScore W4207028823C127561419 @default.
- W4207028823 hasConceptScore W4207028823C160160445 @default.
- W4207028823 hasConceptScore W4207028823C173396325 @default.
- W4207028823 hasConceptScore W4207028823C181199279 @default.
- W4207028823 hasConceptScore W4207028823C185592680 @default.
- W4207028823 hasConceptScore W4207028823C190283241 @default.
- W4207028823 hasConceptScore W4207028823C2776941990 @default.
- W4207028823 hasConceptScore W4207028823C2779134362 @default.
- W4207028823 hasConceptScore W4207028823C502942594 @default.
- W4207028823 hasConceptScore W4207028823C55493867 @default.
- W4207028823 hasConceptScore W4207028823C62203573 @default.
- W4207028823 hasConceptScore W4207028823C86803240 @default.
- W4207028823 hasConceptScore W4207028823C95444343 @default.
- W4207028823 hasIssue "6" @default.
- W4207028823 hasLocation W42070288231 @default.
- W4207028823 hasLocation W42070288232 @default.
- W4207028823 hasOpenAccess W4207028823 @default.
- W4207028823 hasPrimaryLocation W42070288231 @default.
- W4207028823 hasRelatedWork W2810493414 @default.
- W4207028823 hasRelatedWork W2889344839 @default.
- W4207028823 hasRelatedWork W2948011254 @default.
- W4207028823 hasRelatedWork W2964020857 @default.
- W4207028823 hasRelatedWork W2972916078 @default.
- W4207028823 hasRelatedWork W2991252237 @default.
- W4207028823 hasRelatedWork W3010357773 @default.
- W4207028823 hasRelatedWork W3202119051 @default.
- W4207028823 hasRelatedWork W4220866825 @default.
- W4207028823 hasRelatedWork W4281778281 @default.
- W4207028823 hasVolume "24" @default.
- W4207028823 isParatext "false" @default.
- W4207028823 isRetracted "false" @default.
- W4207028823 workType "article" @default.