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- W4207028841 abstract "The development of targeted drug delivery systems with controlled drug release and enhanced drug bioavailability has attracted increasing attention as a candidate for clinical applications. We designed biocompatible citrate-functionalized hydroxyapatite nanorods (Cit-HAp NRs) loaded with artesunate (ART) for use in colon cancer therapies. These were then encapsulated into surfactant free PLGA nanoparticles ([email protected] NRs/SF-PLGA NPs). The synthesized Cit-HAp NRs, ART-loaded Cit-HAp NRs and [email protected] NRs/SF-PLGA NPs were characterized using a variety of comprehensive techniques. An ART loading efficiency of ∼92% was observed upon using a 1:10 mass ratio (ART: Cit-HAp NRs). We revealed that the adsorption of ART on Cit-HAp NRs proceeds via a pseudo-second-order adsorption mechanism. The in vitro ART release from the nanocomposites ([email protected] NRs/SF-PLGA NPs) exhibits a pH dependent release and the rate of ART release from the [email protected] NRs/SF-PLGA NPs was slower than the release from Cit-HAp NRs. The effects of [email protected] NRs/SF-PLGA NPs were evaluated in human colon cancer (HCT 116 and Caco-2) cell lines. [email protected] NRs/SF-PLGA NPs demonstrated higher anti-proliferation activity compared with free ART. The delivery of ART using Citrate-functionalized hydroxyapatite encapsulated, surfactant free PLGA nanoparticles as a carrier could improve their anti-cancer activities." @default.
- W4207028841 created "2022-01-26" @default.
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- W4207028841 date "2022-05-01" @default.
- W4207028841 modified "2023-10-14" @default.
- W4207028841 title "Surfactant free-poly(lactic-co-glycolic acid) coated artesunate loaded citrate-functionalized hydroxyapatite nanorods as a nanocapsule for improving artesunate delivery and antitumor efficiency" @default.
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- W4207028841 doi "https://doi.org/10.1016/j.ceramint.2022.01.223" @default.
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