FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207030461> ?p ?o ?g. }

• W4207030461 endingPage "177" @default.
• W4207030461 startingPage "171" @default.
• W4207030461 abstract "Use of prophylactic antibiotics after stented hypospadias repair is very common, but most research has not identified any clinical benefits of this practice. Only one study has found that postoperative prophylaxis reduces symptomatic urinary tract infections (UTIs). Data from the same trial suggested that prophylaxis may also reduce urethroplasty complications. No studies on this subject have been placebo-controlled.We performed a randomized, double-blind, placebo-controlled study to evaluate the effect of postoperative prophylactic antibiotics on the incidence of infection or urethroplasty complications after stented repair of midshaft-to-distal hypospadias.Boys were eligible for this multicenter trial if they had a primary, single-stage repair of mid-to-distal hypospadias with placement of an open-drainage urethral stent for an intended duration of 5-10 days. Participants were randomized in a double-blind fashion to receive oral trimethoprim-sulfamethoxazole or placebo twice daily for 10 days postoperatively. The primary outcome was a composite of symptomatic UTI, surgical site infection (SSI), and urethroplasty complications, including urethrocutaneous fistula, meatal stenosis, and dehiscence. Secondary outcomes included each component of the primary outcome as well as acute adverse drug reactions (ADRs) and C. difficile colitis.Infection or urethroplasty complications occurred in 10 of 45 boys (22%) assigned to receive antibiotic prophylaxis as compared with 5 of 48 (10%) who received placebo (relative risk [RR], 2.1; 95% confidence interval [CI], 0.8 to 5.8; p = 0.16). There were no significant differences between groups in symptomatic UTIs, SSIs, or any urethroplasty complications. Mild ADRs occurred in 3 of 45 boys (7%) assigned to antibiotics as compared with 5 of 48 (10%) given placebo (RR, 0.6; 95% CI, 0.2 to 2.5; p = 0.72). There were no moderate-to-severe ADRs, and no patients developed C. difficile colitis.In this placebo-controlled trial of 93 patients, prophylactic antibiotics were not found to reduce infection or urethroplasty complications after stented mid-to-distal hypospadias repair. The study did not reach its desired sample size and was therefore underpowered to independently support a conclusion that prophylaxis is not beneficial. However, the result is consistent with most prior research on this subject.NCT02096159." @default.
• W4207030461 created "2022-01-26" @default.
• W4207030461 creator A5004819252 @default.
• W4207030461 creator A5008790787 @default.
• W4207030461 creator A5009043117 @default.
• W4207030461 creator A5009508502 @default.
• W4207030461 creator A5009985476 @default.
• W4207030461 creator A5012060208 @default.
• W4207030461 creator A5012932317 @default.
• W4207030461 creator A5015314527 @default.
• W4207030461 creator A5017398833 @default.
• W4207030461 creator A5019278575 @default.
• W4207030461 creator A5020838821 @default.
• W4207030461 creator A5025063215 @default.
• W4207030461 creator A5036546619 @default.
• W4207030461 creator A5037078110 @default.
• W4207030461 creator A5037851493 @default.
• W4207030461 creator A5043442146 @default.
• W4207030461 creator A5044223441 @default.
• W4207030461 creator A5044853699 @default.
• W4207030461 creator A5046835429 @default.
• W4207030461 creator A5048552971 @default.
• W4207030461 creator A5049946962 @default.
• W4207030461 creator A5056602646 @default.
• W4207030461 creator A5060178414 @default.
• W4207030461 creator A5061973323 @default.
• W4207030461 creator A5065526608 @default.
• W4207030461 creator A5067700920 @default.
• W4207030461 creator A5069790411 @default.
• W4207030461 creator A5079044253 @default.
• W4207030461 date "2022-04-01" @default.
• W4207030461 modified "2023-10-17" @default.
• W4207030461 title "Randomized trial of prophylactic antibiotics vs. placebo after midshaft-to-distal hypospadias repair: the PROPHY Study" @default.
• W4207030461 cites W1857301609 @default.
• W4207030461 cites W1972432468 @default.
• W4207030461 cites W1998366503 @default.
• W4207030461 cites W2004682667 @default.
• W4207030461 cites W2016603764 @default.
• W4207030461 cites W2019713008 @default.
• W4207030461 cites W2036397172 @default.
• W4207030461 cites W2050859142 @default.
• W4207030461 cites W2051186653 @default.
• W4207030461 cites W2093274439 @default.
• W4207030461 cites W2102106080 @default.
• W4207030461 cites W2302483558 @default.
• W4207030461 cites W2347115925 @default.
• W4207030461 cites W2675898096 @default.
• W4207030461 cites W2753665867 @default.
• W4207030461 cites W2790608186 @default.
• W4207030461 cites W2804259456 @default.
• W4207030461 cites W2898672613 @default.
• W4207030461 cites W2944434778 @default.
• W4207030461 cites W3107223996 @default.
• W4207030461 doi "https://doi.org/10.1016/j.jpurol.2022.01.008" @default.
• W4207030461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35144885" @default.
• W4207030461 hasPublicationYear "2022" @default.
• W4207030461 type Work @default.
• W4207030461 citedByCount "7" @default.
• W4207030461 countsByYear W42070304612022 @default.
• W4207030461 countsByYear W42070304612023 @default.
• W4207030461 crossrefType "journal-article" @default.
• W4207030461 hasAuthorship W4207030461A5004819252 @default.
• W4207030461 hasAuthorship W4207030461A5008790787 @default.
• W4207030461 hasAuthorship W4207030461A5009043117 @default.
• W4207030461 hasAuthorship W4207030461A5009508502 @default.
• W4207030461 hasAuthorship W4207030461A5009985476 @default.
• W4207030461 hasAuthorship W4207030461A5012060208 @default.
• W4207030461 hasAuthorship W4207030461A5012932317 @default.
• W4207030461 hasAuthorship W4207030461A5015314527 @default.
• W4207030461 hasAuthorship W4207030461A5017398833 @default.
• W4207030461 hasAuthorship W4207030461A5019278575 @default.
• W4207030461 hasAuthorship W4207030461A5020838821 @default.
• W4207030461 hasAuthorship W4207030461A5025063215 @default.
• W4207030461 hasAuthorship W4207030461A5036546619 @default.
• W4207030461 hasAuthorship W4207030461A5037078110 @default.
• W4207030461 hasAuthorship W4207030461A5037851493 @default.
• W4207030461 hasAuthorship W4207030461A5043442146 @default.
• W4207030461 hasAuthorship W4207030461A5044223441 @default.
• W4207030461 hasAuthorship W4207030461A5044853699 @default.
• W4207030461 hasAuthorship W4207030461A5046835429 @default.
• W4207030461 hasAuthorship W4207030461A5048552971 @default.
• W4207030461 hasAuthorship W4207030461A5049946962 @default.
• W4207030461 hasAuthorship W4207030461A5056602646 @default.
• W4207030461 hasAuthorship W4207030461A5060178414 @default.
• W4207030461 hasAuthorship W4207030461A5061973323 @default.
• W4207030461 hasAuthorship W4207030461A5065526608 @default.
• W4207030461 hasAuthorship W4207030461A5067700920 @default.
• W4207030461 hasAuthorship W4207030461A5069790411 @default.
• W4207030461 hasAuthorship W4207030461A5079044253 @default.
• W4207030461 hasConcept C141071460 @default.
• W4207030461 hasConcept C142724271 @default.
• W4207030461 hasConcept C168563851 @default.
• W4207030461 hasConcept C203092338 @default.
• W4207030461 hasConcept C204787440 @default.
• W4207030461 hasConcept C27081682 @default.
• W4207030461 hasConcept C2776603339 @default.
• W4207030461 hasConcept C2777085111 @default.
• W4207030461 hasConcept C2777990738 @default.

• next