FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207030734> ?p ?o ?g. }

• W4207030734 endingPage "456" @default.
• W4207030734 startingPage "449" @default.
• W4207030734 abstract "Introduction: NMDA receptors are involved in the pathogenesis of seizures, as it subunit is coded for by the GRIN1 gene. Different GRIN1 mutations are known in patients with different forms of epilepsy and encephalopathy. However, no data are available on the participation of the GRIN1 gene and its polymorphisms in the development of post-traumatic epilepsy (PTE). Aim: To determine the influence of single-nucleotide rs1126442 polymorphism of GRIN1 on the risk of PTE formation. Materials and methods: A total of 140 patients were examined, which included 69 patients with PTE and 71 patients with genetic epilepsy. All patients underwent a comprehensive examination, with evaluation of history, neurological status, electroencephalography (EEG) and neuroimaging results, and genotyping of blood samples by real-time polymerase chain reaction. The control sample for genetic examination was venous blood from 60 healthy individuals. Results: Focal seizures with transition to bilateral and tonicclonic seizures were predominant in the PTE group. Neuroimaging revealed dystrophic, cystic, and cystogliotic alterations and signs of external hydrocephaly. EEG recorded interictal and ictal epileptiform activity and slowing of theta waves. Genotyping by rs1126442 polymorphism of GRIN1 revealed predominance of heterozygous G/A and homozygous A/A genotypes in patients with PTE in the codominant (odds ratio (OD)=3.43; 95% confidence index (CI) 1.567.55; p=0.0047), dominant (OR=3.24; 95% CI 1.576.68; p=0.0011), and superdominant (OR=2.90; 95% CI 1.366.22; p=0.0048) inheritance models. The carriage of heterozygous G/A rs1126442 genotype of GRIN1 was associated with an epileptiform activity in the EEG of all patients with epilepsy (OR=2.40; 95% CI 1.115.20; p=0.024). Conclusion: The carriage of heterozygous G/A genotype and homozygous A/A rs 1126442 genotype of GRIN1 in the dominant and codominant inheritance models is associated with a high risk of development of epilepsy after craniocerebral trauma. The carriage of heterozygous G/A rs 1126442 genotype of GRIN1 is associated with an epileptiform activity in EEG." @default.
• W4207030734 created "2022-01-26" @default.
• W4207030734 creator A5000053956 @default.
• W4207030734 creator A5022479949 @default.
• W4207030734 creator A5036887951 @default.
• W4207030734 creator A5085720233 @default.
• W4207030734 date "2021-12-15" @default.
• W4207030734 modified "2023-09-26" @default.
• W4207030734 title "Role of the <i>GRIN1</i> gene polymorphism in the formation of post-traumatic epilepsy" @default.
• W4207030734 cites W1993481250 @default.
• W4207030734 cites W2041963937 @default.
• W4207030734 cites W2084556785 @default.
• W4207030734 cites W2589239610 @default.
• W4207030734 cites W2612035552 @default.
• W4207030734 cites W2940329536 @default.
• W4207030734 cites W4210593087 @default.
• W4207030734 doi "https://doi.org/10.17816/pavlovj63933" @default.
• W4207030734 hasPublicationYear "2021" @default.
• W4207030734 type Work @default.
• W4207030734 citedByCount "0" @default.
• W4207030734 crossrefType "journal-article" @default.
• W4207030734 hasAuthorship W4207030734A5000053956 @default.
• W4207030734 hasAuthorship W4207030734A5022479949 @default.
• W4207030734 hasAuthorship W4207030734A5036887951 @default.
• W4207030734 hasAuthorship W4207030734A5085720233 @default.
• W4207030734 hasBestOaLocation W42070307341 @default.
• W4207030734 hasConcept C104317684 @default.
• W4207030734 hasConcept C118552586 @default.
• W4207030734 hasConcept C126322002 @default.
• W4207030734 hasConcept C135763542 @default.
• W4207030734 hasConcept C149737253 @default.
• W4207030734 hasConcept C156957248 @default.
• W4207030734 hasConcept C17755696 @default.
• W4207030734 hasConcept C2778186239 @default.
• W4207030734 hasConcept C54355233 @default.
• W4207030734 hasConcept C71924100 @default.
• W4207030734 hasConcept C86803240 @default.
• W4207030734 hasConceptScore W4207030734C104317684 @default.
• W4207030734 hasConceptScore W4207030734C118552586 @default.
• W4207030734 hasConceptScore W4207030734C126322002 @default.
• W4207030734 hasConceptScore W4207030734C135763542 @default.
• W4207030734 hasConceptScore W4207030734C149737253 @default.
• W4207030734 hasConceptScore W4207030734C156957248 @default.
• W4207030734 hasConceptScore W4207030734C17755696 @default.
• W4207030734 hasConceptScore W4207030734C2778186239 @default.
• W4207030734 hasConceptScore W4207030734C54355233 @default.
• W4207030734 hasConceptScore W4207030734C71924100 @default.
• W4207030734 hasConceptScore W4207030734C86803240 @default.
• W4207030734 hasIssue "4" @default.
• W4207030734 hasLocation W42070307341 @default.
• W4207030734 hasOpenAccess W4207030734 @default.
• W4207030734 hasPrimaryLocation W42070307341 @default.
• W4207030734 hasRelatedWork W1992703474 @default.
• W4207030734 hasRelatedWork W2042693310 @default.
• W4207030734 hasRelatedWork W2069659939 @default.
• W4207030734 hasRelatedWork W2281456597 @default.
• W4207030734 hasRelatedWork W2385830983 @default.
• W4207030734 hasRelatedWork W2389943397 @default.
• W4207030734 hasRelatedWork W2402934723 @default.
• W4207030734 hasRelatedWork W2531233444 @default.
• W4207030734 hasRelatedWork W3000795230 @default.
• W4207030734 hasRelatedWork W4213015653 @default.
• W4207030734 hasVolume "29" @default.
• W4207030734 isParatext "false" @default.
• W4207030734 isRetracted "false" @default.
• W4207030734 workType "article" @default.